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Vol. 16 (2024)

Self-Healing Dynamic Hydrogel Microparticles with Structural Color for Wound Management

https://doi.org/10.1007/s40820-024-01422-4
Li Wang
Department of General Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, People’s Republic of China
Xiaoya Ding
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, People’s Republic of China
Lu Fan
Pharmaceutical Sciences Laboratory, Åbo Akademi University, 20520 Turku, Finland
Anne M. Filppula
Pharmaceutical Sciences Laboratory, Åbo Akademi University, 20520 Turku, Finland
Qinyu Li
Department of General Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, People’s Republic of China
Hongbo Zhang
Department of General Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, People’s Republic of China
Yuanjin Zhao
Department of General Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, People’s Republic of China
Luoran Shang
Department of General Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, People’s Republic of China

Corresponding Author: Luoran Shang

luoranshang@fudan.edu.cn

Nano-Micro Letters, Vol. 16 (2024), Article Number: 232

Abstract

Chronic diabetic wounds confront a significant medical challenge because of increasing prevalence and difficult-healing circumstances. It is vital to develop multifunctional hydrogel dressings, with well-designed morphology and structure to enhance flexibility and effectiveness in wound management. To achieve these, we propose a self-healing hydrogel dressing based on structural color microspheres for wound management. The microsphere comprised a photothermal-responsive inverse opal framework, which was constructed by hyaluronic acid methacryloyl, silk fibroin methacryloyl and black phosphorus quantum dots (BPQDs), and was further re-filled with a dynamic hydrogel. The dynamic hydrogel filler was formed by Knoevenagel condensation reaction between cyanoacetate and benzaldehyde-functionalized dextran (DEX-CA and DEX-BA). Notably, the composite microspheres can be applied arbitrarily, and they can adhere together upon near-infrared irradiation by leveraging the BPQDs-mediated photothermal effect and the thermoreversible stiffness change of dynamic hydrogel. Additionally, eumenitin and vascular endothelial growth factor were co-loaded in the microspheres and their release behavior can be regulated by the same mechanism. Moreover, effective monitoring of the drug release process can be achieved through visual color variations. The microsphere system has demonstrated desired capabilities of controllable drug release and efficient wound management. These characteristics suggest broad prospects for the proposed composite microspheres in clinical applications.


Highlights:
1 Derived from silica photonic crystals, inverse opal microspheres have a regularly connected porous structure and inherit structural color properties.
2 Combined with the stable scaffold and the photothermal phase-transition of the secondary filling material, the inverse opal composite microspheres are endowed with self-healing properties and the ability for controllable drug release.
3 Inverse opal microspheres were significantly treated for diabetic wound, via promoting tissue regeneration, collagen deposition and angiogenesis. Meanwhile, the release of drugs could be monitored by the structural color characteristic.

Keywords

Black phosphorus Structural color Dynamic hydrogel Inverse opal Wound management
Wang, Li, Xiaoya Ding, Lu Fan, Anne M. Filppula, Qinyu Li, Hongbo Zhang, Yuanjin Zhao, and Luoran Shang. 2024. “Self-Healing Dynamic Hydrogel Microparticles With Structural Color for Wound Management”. Nano-Micro Letters 16 (July):232. https://doi.org/10.1007/s40820-024-01422-4.
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