Issue

Vol. 14 (2022)

Biomass Microcapsules with Stem Cell Encapsulation for Bone Repair

https://doi.org/10.1007/s40820-021-00747-8
Lei Yang
Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, People’s Republic of China
Yuxiao Liu
Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, People’s Republic of China
Lingyu Sun
Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, People’s Republic of China
Cheng Zhao
Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, People’s Republic of China
Guopu Chen
Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, People’s Republic of China
Yuanjin Zhao
Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, People’s Republic of China

Corresponding Author: Yuanjin Zhao

yjzhao@seu.edu.cn

Nano-Micro Letters, Vol. 14 (2022), Article Number: 4

Abstract

Bone defects caused by trauma, tumor, or osteoarthritis remain challenging due to the lack of effective treatments in clinic. Stem cell transplantation has emerged as an alternative approach for bone repair and attracted widespread attention owing to its excellent biological activities and therapy effect. The attempts to develop this therapeutic approach focus on the generation of effective cell delivery vehicles, since the shortcomings of direct injection of stem cells into target tissues. Here, we developed a novel core-shell microcapsule with a stem cell-laden core and a biomass shell by using all-aqueous phase microfluidic electrospray technology. The designed core-shell microcapsules showed a high cell viability during the culture procedure. In addition, the animal experiments exhibited that stem cell-laden core-shell microcapsules have good biocompatibility and therapeutic effect for bone defects. This study indicated that the core-shell biomass microcapsules generated by microfluidic electrospray have promising potential in tissue engineering and regenerative medicine.


Highlights:


1 A novel stem cell delivery core-shell biomass microcapsule was generated by an all-aqueous phase microfluidic electrospray technique.
2 Microcapsule with a certain mechanical strength and porous structure is beneficial for substances exchange between cells and the external environment, together with avoiding cell damage during treatment.
3 Core-shell microcapsule provided a favorable cell growth microenvironment, which mimics a physicochemical microenvironment and protects the cells from the immune attack from body.

Keywords

Microcapsule Bone repair Stem cell therapy Microfluidics Electrospray
Yang, Lei, Yuxiao Liu, Lingyu Sun, Cheng Zhao, Guopu Chen, and Yuanjin Zhao. 2021. “Biomass Microcapsules With Stem Cell Encapsulation for Bone Repair”. Nano-Micro Letters 14 (December):4. https://doi.org/10.1007/s40820-021-00747-8.
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