Issue

Vol. 13 (2021)

Prevascularized Micro-/Nano-Sized Spheroid/Bead Aggregates for Vascular Tissue Engineering

https://doi.org/10.1007/s40820-021-00697-1
Maedeh Rahimnejad
Biomedical Engineering Institute, School of Medicine, Université de Montréal, Montreal, Canada
Narges Nasrollahi Boroujeni
Department of Industrial Biotechnology, National Institute of Genetics and Biotechnology, Tehran, Iran
Sepideh Jahangiri
Research Centre, Centre Hospitalier de L’Université de Montréal (CRCHUM), Montreal, Canada
Navid Rabiee
Department of Physics, Sharif University of Technology, P.O. Box 11155‑9161, Tehran, Iran
Mohammad Rabiee
Biomaterial Group, Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran
Pooyan Makvandi
Centre for Materials Interfaces, Istituto Italiano Di Tecnologia, viale Rinaldo Piaggio 34, 56 025 Pontedera, Pisa, Italy
Omid Akhavan
Department of Physics, Sharif University of Technology, P.O. Box 11155‑9161, Tehran, Iran
Rajender S. Varma
Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute, Palacky University, Šlechtitelů 27, 783 71 Olomouc, Czech Republic

Corresponding Author: Rajender S. Varma

varma.rajender@epa.gov

Nano-Micro Letters, Vol. 13 (2021), Article Number: 182

Abstract

Efficient strategies to promote microvascularization in vascular tissue engineering, a central priority in regenerative medicine, are still scarce; nano- and micro-sized aggregates and spheres or beads harboring primitive microvascular beds are promising methods in vascular tissue engineering. Capillaries are the smallest type and in numerous blood vessels, which are distributed densely in cardiovascular system. To mimic this microvascular network, specific cell components and proangiogenic factors are required. Herein, advanced biofabrication methods in microvascular engineering, including extrusion-based and droplet-based bioprinting, Kenzan, and biogripper approaches, are deliberated with emphasis on the newest works in prevascular nano- and micro-sized aggregates and microspheres/microbeads.


Highlights:


1 The first perspective regarding the application of nano-micro size aggregations on the prevascularizations and biomedicine.
2 This perspective provides an in-depth discussion regarding the use of these prevascularized nano-micro size aggregates in biomedicine and regenerative medicine.


 

Keywords

Vascular tissue engineering Nano-/micro-sized aggregates Microspheres
Rahimnejad, Maedeh, Narges Nasrollahi Boroujeni, Sepideh Jahangiri, Navid Rabiee, Mohammad Rabiee, Pooyan Makvandi, Omid Akhavan, and Rajender S. Varma. 2021. “Prevascularized Micro-/Nano-Sized Spheroid/Bead Aggregates for Vascular Tissue Engineering”. Nano-Micro Letters 13 (August):182. https://doi.org/10.1007/s40820-021-00697-1.
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