Issue

Vol. 14 (2022)

MXene-Graphene Composites: A Perspective on Biomedical Potentials

https://doi.org/10.1007/s40820-022-00880-y
Ebrahim Mostafavi
Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA
https://orcid.org/0000-0003-3958-5002
Siavash Iravani
Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
https://orcid.org/0000-0003-3985-7928

Corresponding Author: Siavash Iravani

siavashira@gmail.com

Nano-Micro Letters, Vol. 14 (2022), Article Number: 130

Abstract

MXenes, transition metal carbides and nitrides with graphene-like structures, have received considerable attention since their first discovery. On the other hand, Graphene has been extensively used in biomedical and medicinal applications. MXene and graphene, both as promising candidates of two-dimensional materials, have shown to possess high potential in future biomedical applications due to their unique physicochemical properties such as superior electrical conductivity, high biocompatibility, large surface area, optical and magnetic features, and extraordinary thermal and mechanical properties. These special structural, functional, and biological characteristics suggest that the hybrid/composite structure of MXene and graphene would be able to meet many unmet needs in different fields; particularly in medicine and biomedical engineering, where high-performance mechanical, electrical, thermal, magnetic, and optical requirements are necessary. However, the hybridization and surface functionalization should be further explored to obtain biocompatible composites/platforms with unique physicochemical properties, high stability, and multifunctionality. In addition, toxicological and long-term biosafety assessments and clinical translation evaluations should be given high priority in research. Although very limited studies have revealed the excellent potentials of MXene/graphene in biomedicine, the next steps should be toward the extensive research and detailed analysis in optimizing the properties and improving their functionality with a clinical and industrial outlook. Herein, different synthesis/fabrication methods and performances of MXene/graphene composites are discussed for potential biomedical applications. The potential toxicological effects of these composites on human cells and tissues are also covered, and future perspectives toward more successful translational applications are presented. The current state-of-the-art biotechnological advances in the use of MXene-Graphene composites, as well as their developmental challenges and future prospects are also deliberated. Due to the superior properties and multifunctionality of MXene-graphene composites, these hybrid structures can open up considerable new horizons in future of healthcare and medicine.


Highlights:


1 MXene/graphene composites possess high potential in future biomedical applications.
2 The hybridization and surface functionalization of MXene-graphene composites should be further explored to improve the biocompatibility, high stability, and multifunctionality.
3 The synthesis methods, performances, potential toxicologies, as well as future perspectives of MXene/graphene composites are discussed.

Keywords

Graphene MXene Composites Hybrid structures Biocompatibility Cancer theranostics Biomedical engineering
Mostafavi, Ebrahim, and Siavash Iravani. 2022. “MXene-Graphene Composites: A Perspective on Biomedical Potentials”. Nano-Micro Letters 14 (June):130. https://doi.org/10.1007/s40820-022-00880-y.
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