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Vol. 13 (2021)

Injectable Self-Healing Adhesive pH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing

https://doi.org/10.1007/s40820-020-00585-0
Jiahui He
Department of Gastroenterology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China
Zixi Zhang
Department of Gastroenterology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China
Yutong Yang
Department of Gastroenterology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China
Fenggang Ren
National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine and Surgical Engineering Research Center of Shaanxi Province, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China
Jipeng Li
Department of Experimental Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China
Shaojun Zhu
Department of Pathology, Tangdu Hospital, Fourth Military Medical University, Xi’an, People’s Republic of China
Feng Ma
National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine and Surgical Engineering Research Center of Shaanxi Province, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China
Rongqian Wu
National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine and Surgical Engineering Research Center of Shaanxi Province, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China
Yi Lv
National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine and Surgical Engineering Research Center of Shaanxi Province, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China
Gang He
Frontier Institute of Science and Technology, and State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an 710049, China
Baolin Guo
Department of Gastroenterology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China
Dake Chu
Department of Gastroenterology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, People’s Republic of China

Corresponding Author: Dake Chu

chudake@xjtu.edu.cn

Nano-Micro Letters, Vol. 13 (2021), Article Number: 80

Abstract

Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are well-established therapeutics for gastrointestinal neoplasias, but complications after EMR/ESD, including bleeding and perforation, result in additional treatment morbidity and even threaten the lives of patients. Thus, designing biomaterials to treat gastric bleeding and wound healing after endoscopic treatment is highly desired and remains a challenge. Herein, a series of injectable pH-responsive self-healing adhesive hydrogels based on acryloyl-6-aminocaproic acid (AA) and AA-g-N-hydroxysuccinimide (AA-NHS) were developed, and their great potential as endoscopic sprayable bioadhesive materials to efficiently stop hemorrhage and promote the wound healing process was further demonstrated in a swine gastric hemorrhage/wound model. The hydrogels showed a suitable gelation time, an autonomous and efficient self-healing capacity, hemostatic properties, and good biocompatibility. With the introduction of AA-NHS as a micro-cross-linker, the hydrogels exhibited enhanced adhesive strength. A swine gastric hemorrhage in vivo model demonstrated that the hydrogels showed good hemostatic performance by stopping acute arterial bleeding and preventing delayed bleeding. A gastric wound model indicated that the hydrogels showed excellent treatment effects with significantly enhanced wound healing with type I collagen deposition, α-SMA expression, and blood vessel formation. These injectable self-healing adhesive hydrogels exhibited great potential to treat gastric wounds after endoscopic treatment.


Highlights:


1 A series of novel injectable pH-responsive self-healing hydrogels with enhanced adhesive strength were prepared.
2 The hydrogels showed good gastric hemostasis property in a swine gastric hemorrhage model.
3 The hydrogels greatly enhanced gastric wound healing in a swine gastric wound model.

Keywords

Injectable self-healing hydrogel Adhesive hydrogel Gastric hemostasis Gastric wound healing Endoscopic treatment
He, Jiahui, Zixi Zhang, Yutong Yang, Fenggang Ren, Jipeng Li, Shaojun Zhu, Feng Ma, Rongqian Wu, Yi Lv, Gang He, Baolin Guo, and Dake Chu. 2021. “Injectable Self-Healing Adhesive PH-Responsive Hydrogels Accelerate Gastric Hemostasis and Wound Healing”. Nano-Micro Letters 13 (February):80. https://doi.org/10.1007/s40820-020-00585-0.
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