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Vol. 12 (2020)

Soft Mesoporous Organosilica Nanoplatforms Improve Blood Circulation, Tumor Accumulation/Penetration, and Photodynamic Efficacy

https://doi.org/10.1007/s40820-020-00465-7
Xin Peng
Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, Jiangsu, People’s Republic of China
Kun Chen
Key Laboratory for Organic Electronics and Information Displays, Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials, Jiangsu National Synergetic Innovation Centre for Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210023, People’s Republic of China
Wanhua Liu
Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, Jiangsu, People’s Republic of China
Xiongfeng Cao
Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang 212001, People’s Republic of China
Mengru Wang
Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, Jiangsu, People’s Republic of China
Jun Tao
Key Laboratory for Organic Electronics and Information Displays, Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials, Jiangsu National Synergetic Innovation Centre for Advanced Materials, Nanjing University of Posts and Telecommunications, Nanjing 210023, People’s Republic of China
Ying Tian
Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, People’s Republic of China
Lei Bao
Soft Matter and Interface Group, School of Engineering, RMIT University, Melbourne, VIC 3000, Australia
Guangming Lu
Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, People’s Republic of China
Zhaogang Teng
Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, People’s Republic of China

Corresponding Author: Zhaogang Teng

iamzgteng@njupt.edu.cn

Nano-Micro Letters, Vol. 12 (2020), Article Number: 137

Abstract

To date, the ability of nanoplatforms to achieve excellent therapeutic responses is hindered by short blood circulation and limited tumor accumulation/penetration. Herein, a soft mesoporous organosilica nanoplatform modified with hyaluronic acid and cyanine 5.5 are prepared, denoted SMONs-HA-Cy5.5, and comparative studies between SMONs-HA-Cy5.5 (24.2 MPa) and stiff counterparts (79.2 MPa) are conducted. Results indicate that, apart from exhibiting a twofold increase in tumor cellular uptake, the soft nanoplatforms also display a remarkable pharmacokinetic advantage, resulting in considerably improved tumor accumulation. Moreover, SMONs-HA-Cy5.5 exhibits a significantly higher tumor penetration, achieving 30-μm deeper tissue permeability in multicellular spheroids relative to the stiff counterparts. Results further reveal that the soft nanoplatforms have an easier extravasation from the tumor vessels, diffuse farther in the dense extracellular matrix, and reach deeper tumor tissues compared to the stiff ones. Specifically, the soft nanoplatforms generate a 16-fold improvement (43 vs. 2.72 μm) in diffusion distance in tumor parenchyma. Based on the significantly improved blood circulation and tumor accumulation/penetration, a soft therapeutic nanoplatform is constructed by loading photosensitizer chlorin e6 in SMONs-HA-Cy5.5. The resulting nanoplatform exhibits considerably higher therapeutic efficacy on tumors compared to the stiff ones.


Highlights:


1 Soft mesoporous organosilica nanoplatforms modified with hyaluronic acid and cyanine 5.5 are constructed.
2 Therapeutic efficacy of the soft nanoplatforms on tumor is higher both in vitro and in vivo after loading photosensitizer chlorin e6 compared to that of stiff counterparts.

Keywords

Mesoporous organosilica Soft nanoplatform Long circulation Tumor accumulation Tumor penetration
Peng, Xin, Kun Chen, Wanhua Liu, Xiongfeng Cao, Mengru Wang, Jun Tao, Ying Tian, Lei Bao, Guangming Lu, and Zhaogang Teng. 2020. “Soft Mesoporous Organosilica Nanoplatforms Improve Blood Circulation, Tumor Accumulation/Penetration, and Photodynamic Efficacy”. Nano-Micro Letters 12 (June):137. https://doi.org/10.1007/s40820-020-00465-7.
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