Issue

Vol. 17 (2025)

Unleashing the Potential of Electroactive Hybrid Biomaterials and Self-Powered Systems for Bone Therapeutics

https://doi.org/10.1007/s40820-024-01536-9
Shichang Liu
Honghui Hospital, Xi’an Jiaotong University, Xi’an 710018, People’s Republic of China
Farid Manshaii
Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California Los Angeles, Los Angeles 90095, USA
Jinmiao Chen
Hangzhou Institute of Technology, Xidian University, Hangzhou 311231, People’s Republic of China
Xinfei Wang
Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California Los Angeles, Los Angeles 90095, USA
Shaolei Wang
Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California Los Angeles, Los Angeles 90095, USA
Junyi Yin
Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California Los Angeles, Los Angeles 90095, USA
Ming Yang
Honghui Hospital, Xi’an Jiaotong University, Xi’an 710018, People’s Republic of China
Xuxu Chen
Honghui Hospital, Xi’an Jiaotong University, Xi’an 710018, People’s Republic of China
Xinhua Yin
Honghui Hospital, Xi’an Jiaotong University, Xi’an 710018, People’s Republic of China
Yunlei Zhou
Hangzhou Institute of Technology, Xidian University, Hangzhou 311231, People’s Republic of China

Corresponding Author: Xinhua Yin

YIN700@outlook.com

Nano-Micro Letters, Vol. 17 (2025), Article Number: 44

Abstract

The incidence of large bone defects caused by traumatic injury is increasing worldwide, and the tissue regeneration process requires a long recovery time due to limited self-healing capability. Endogenous bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and regeneration. Inspired by bioelectricity, electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix, thereby accelerating bone regeneration. With ongoing advances in biomaterials and energy-harvesting techniques, electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone tissue. In this review, we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and tissue. Next, we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue engineering. Finally, we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.


Highlights:
1 Introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and tissue.
2 Highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices in bone tissue engineering.
3 Emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics.

Keywords

Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue
Liu, Shichang, Farid Manshaii, Jinmiao Chen, Xinfei Wang, Shaolei Wang, Junyi Yin, Ming Yang, Xuxu Chen, Xinhua Yin, and Yunlei Zhou. 2024. “Unleashing the Potential of Electroactive Hybrid Biomaterials and Self-Powered Systems for Bone Therapeutics”. Nano-Micro Letters 17 (October):44. https://doi.org/10.1007/s40820-024-01536-9.
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