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Vol. 11 (2019)

Antiangiogenesis-Combined Photothermal Therapy in the Second Near-Infrared Window at Laser Powers Below the Skin Tolerance Threshold

https://doi.org/10.1007/s40820-019-0327-4
Jian‑Li Chen
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, People’s Republic of China
Han Zhang
Department of Physics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, People’s Republic of China
Xue‑Qin Huang
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, People’s Republic of China
Hong‑Ye Wan
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, People’s Republic of China
Jie Li
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, People’s Republic of China
Xing‑Xing Fan
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, People’s Republic of China
Kathy Qian Luo
Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, People’s Republic of China
Jinhua Wang
Beijing Key Laboratory of Drug Targets Research and New Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People’s Republic of China
Xiao‑Ming Zhu
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau SAR, People’s Republic of China
Jianfang Wang
Department of Physics, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, People’s Republic of China

Corresponding Author: Jianfang Wang

jfwang@phy.cuhk.edu.hk

Nano-Micro Letters, Vol. 11 (2019), Article Number: 93

Abstract

Photothermal agents with strong light absorption in the second near-infrared (NIR-II) region (1000–1350 nm) are strongly desired for successful photothermal therapy (PTT). In this work, titania-coated Au nanobipyramids (NBP@TiO2) with a strong plasmon resonance in the NIR-II window were synthesized. The NBP@TiO2 nanostructures have a high photothermal conversion efficiency of (93.3 ± 5.2)% under 1064-nm laser irradiation. They are also capable for loading an anticancer drug combretastatin A-4 phosphate (CA4P). In vitro PTT studies reveal that 1064-nm laser irradiation can efficiently ablate human lung cancer A549 cells and enhance the anticancer effect of CA4P. Moreover, the CA4P-loaded NBP@TiO2 nanostructures combined with PTT induce a synergistic antiangiogenesis effect. In vivo studies show that such CA4P-loaded NBP@TiO2 nanostructures under mild 1064-nm laser irradiation at an optical power density of 0.4 W cm−2, which is lower than the skin tolerance threshold value, exhibit a superior antitumor effect. This work presents not only the development of the NBP@TiO2 nanostructures as a novel photothermal agent responsive in the NIR-II window but also a unique combined chemo-photothermal therapy strategy for cancer therapy.


Highlights:


1 Titania-coated Au nanobipyramids (NBP@TiO2) with a high photothermal conversion efficiency in the NIR-II window are synthesized.
2 The TiO2 shell is capable for the loading of the anticancer drug combretastatin A-4 phosphate (CA4P).
3 The CA4P-loaded NBP@TiO2 nanostructures subjected with photothermal therapy induce synergistic anticancer and antiangiogenesis effects under 1064-nm laser irradiation at a power density lower than the skin tolerance threshold value.

Keywords

Antiangiogenesis therapy Core@shell nanostructures Gold nanobipyramids Photothermal therapy Plasmon resonance
Chen, Jian‑Li, Han Zhang, Xue‑Qin Huang, Hong‑Ye Wan, Jie Li, Xing‑Xing Fan, Kathy Qian Luo, Jinhua Wang, Xiao‑Ming Zhu, and Jianfang Wang. 2019. “Antiangiogenesis-Combined Photothermal Therapy in the Second Near-Infrared Window at Laser Powers Below the Skin Tolerance Threshold”. Nano-Micro Letters 11 (October):93. https://doi.org/10.1007/s40820-019-0327-4.
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