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Vol. 11 (2019)

Correction to: Fluorescent Silicon Nanorods‑Based Nanotheranostic Agents for Multimodal Imaging‑Guided Photothermal Therapy

https://doi.org/10.1007/s40820-019-0318-5
Mingyue Cui
Laboratory of Nanoscale Biochemical Analysis Institute of Functional Nano & Soft Materials (FUNSOM), and Jiangsu Key Laboratory for Carbon‑Based Functional Materials & Devices, Soochow University, 199 Ren’ai Road, Suzhou 215123, Jiangsu, People’s Republic of China
Sangmo Liu
Laboratory of Nanoscale Biochemical Analysis Institute of Functional Nano & Soft Materials (FUNSOM), and Jiangsu Key Laboratory for Carbon‑Based Functional Materials & Devices, Soochow University, 199 Ren’ai Road, Suzhou 215123, Jiangsu, People’s Republic of China
Bin Song
Laboratory of Nanoscale Biochemical Analysis Institute of Functional Nano & Soft Materials (FUNSOM), and Jiangsu Key Laboratory for Carbon‑Based Functional Materials & Devices, Soochow University, 199 Ren’ai Road, Suzhou 215123, Jiangsu, People’s Republic of China
Daoxia Guo
Laboratory of Nanoscale Biochemical Analysis Institute of Functional Nano & Soft Materials (FUNSOM), and Jiangsu Key Laboratory for Carbon‑Based Functional Materials & Devices, Soochow University, 199 Ren’ai Road, Suzhou 215123, Jiangsu, People’s Republic of China
Jinhua Wang
Laboratory of Nanoscale Biochemical Analysis Institute of Functional Nano & Soft Materials (FUNSOM), and Jiangsu Key Laboratory for Carbon‑Based Functional Materials & Devices, Soochow University, 199 Ren’ai Road, Suzhou 215123, Jiangsu, People’s Republic of China
Guyue Hu
Laboratory of Nanoscale Biochemical Analysis Institute of Functional Nano & Soft Materials (FUNSOM), and Jiangsu Key Laboratory for Carbon‑Based Functional Materials & Devices, Soochow University, 199 Ren’ai Road, Suzhou 215123, Jiangsu, People’s Republic of China
Yuanyuan Su
Laboratory of Nanoscale Biochemical Analysis Institute of Functional Nano & Soft Materials (FUNSOM), and Jiangsu Key Laboratory for Carbon‑Based Functional Materials & Devices, Soochow University, 199 Ren’ai Road, Suzhou 215123, Jiangsu, People’s Republic of China
Yao He
Laboratory of Nanoscale Biochemical Analysis Institute of Functional Nano & Soft Materials (FUNSOM), and Jiangsu Key Laboratory for Carbon‑Based Functional Materials & Devices, Soochow University, 199 Ren’ai Road, Suzhou 215123, Jiangsu, People’s Republic of China

Corresponding Author: Yao He

yaohe@suda.edu.cn

Nano-Micro Letters, Vol. 11 (2019), Article Number: 85

Abstract

The utilization of diagnosis to guide/aid therapy procedures has shown great prospects in the era of personalized medicine along with the recognition of tumor heterogeneity and complexity. Herein, a kind of multifunctional silicon-based nanostructure, i.e., gold nanoparticles-decorated fluorescent silicon nanorods (Au@SiNRs), is fabricated and exploited for tumor-targeted multimodal imaging-guided photothermal therapy. In particular, the prepared Au@SiNRs feature high photothermal conversion efficiency (~ 43.9%) and strong photothermal stability (photothermal performance stays constant after five-cycle NIR laser irradiation), making them high-performance agents for simultaneously photoacoustic and infrared thermal imaging. The Au@SiNRs are readily modified with targeting peptide ligands, enabling an enhanced tumor accumulation with a high value of ~ 8.74% ID g−1. Taking advantages of these unique merits, the Au@SiNRs are superbly suitable for specifically ablating tumors in vivo without appreciable toxicity under the guidance of multimodal imaging. Typically, all the mice treated with the Au@SiNRs remain alive, and no distinct tumor recurrence is observed during 60-day investigation.


Highlights:


1 A kind of multifunctional silicon-based theranostic agent is fabricated and exploited for imaging-guided tumor-targeted photothermal therapy.
2 The obtained gold nanoparticles-decorated fluorescent silicon nanorods featuring high photothermal conversion performance and good photothermal stability enable a total ablation of tumors and prolong the survival time of mice.

Keywords

Gold nanoparticle Fluorescent silicon nanorods Nanotheranostic Multimodal imaging Photothermal therapy Tumor target
Cui, Mingyue, Sangmo Liu, Bin Song, Daoxia Guo, Jinhua Wang, Guyue Hu, Yuanyuan Su, and Yao He. 2019. “Correction To: Fluorescent Silicon Nanorods‑Based Nanotheranostic Agents for Multimodal Imaging‑Guided Photothermal Therapy”. Nano-Micro Letters 11 (October):85. https://doi.org/10.1007/s40820-019-0318-5.
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