Issue

Vol. 12 (2020)

Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics

https://doi.org/10.1007/s40820-020-00485-3
Xin Pang
Henan Key Laboratory of Functional Magnetic Resonance Imaging and Molecular Imaging, Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, 450052 Zhengzhou, People’s Republic of China
Dengfeng Li
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 361102 Xiamen, People’s Republic of China
Jing Zhu
Henan Key Laboratory of Functional Magnetic Resonance Imaging and Molecular Imaging, Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, 450052 Zhengzhou, People’s Republic of China
Jingliang Cheng
Henan Key Laboratory of Functional Magnetic Resonance Imaging and Molecular Imaging, Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, 450052 Zhengzhou, People’s Republic of China
Gang Liu
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, 361102 Xiamen, People’s Republic of China

Corresponding Author: Gang Liu

gangliu.cmitm@xmu.edu.cn

Nano-Micro Letters, Vol. 12 (2020), Article Number: 144

Abstract

Rapid evolution and propagation of multidrug resistance among bacterial pathogens are outpacing the development of new antibiotics, but antimicrobial photodynamic therapy (aPDT) provides an excellent alternative. This treatment depends on the interaction between light and photoactivated sensitizer to generate reactive oxygen species (ROS), which are highly cytotoxic to induce apoptosis in virtually all microorganisms without resistance concern. When replacing light with low-frequency ultrasonic wave to activate sensitizer, a novel ultrasound-driven treatment emerges as antimicrobial sonodynamic therapy (aSDT). Recent advances in aPDT and aSDT reveal golden opportunities for the management of multidrug resistant bacterial infections, especially in the theranostic application where imaging diagnosis can be accomplished facilely with the inherent optical characteristics of sensitizers, and the generated ROS by aPDT/SDT cause broad-spectrum oxidative damage for sterilization. In this review, we systemically outline the mechanisms, targets, and current progress of aPDT/SDT for bacterial theranostic application. Furthermore, potential limitations and future perspectives are also highlighted.


Highlights:


1 Recent advances in bacterial theranostics using antimicrobial photo/sonodynamic therapy (aPDT/SDT) are summarized in this review.
2 The inherent optical characteristics of photo/sonosensitizers facilely enable imaging diagnosis of bacterial infections.
3 Reactive oxygen species as the killing effector of aPDT/SDT cause broad-spectrum damage for sterilization with no concern about antibiotic resistance.

Keywords

Photodynamic therapy Sonodynamic therapy Theranostics Multidrug resistant Reactive oxygen species
Pang, Xin, Dengfeng Li, Jing Zhu, Jingliang Cheng, and Gang Liu. 2020. “Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics”. Nano-Micro Letters 12 (July):144. https://doi.org/10.1007/s40820-020-00485-3.
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