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Vol. 14 (2022)

Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy

https://doi.org/10.1007/s40820-022-00894-6
Shuang Bai
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, People’s Republic of China
Yulu Lan
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, People’s Republic of China
Shiying Fu
State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen 361102, People’s Republic of China
Hongwei Cheng
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, People’s Republic of China
Zhixiang Lu
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, People’s Republic of China
Gang Liu
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, People’s Republic of China

Corresponding Author: Gang Liu

gangliu.cmitm@xmu.edu.cn

Nano-Micro Letters, Vol. 14 (2022), Article Number: 145

Abstract

As the indispensable second cellular messenger, calcium signaling is involved in the regulation of almost all physiological processes by activating specific target proteins. The importance of calcium ions (Ca2+) makes its “Janus nature” strictly regulated by its concentration. Abnormal regulation of calcium signals may cause some diseases; however, artificial regulation of calcium homeostasis in local lesions may also play a therapeutic role. “Calcium overload,” for example, is characterized by excessive enrichment of intracellular Ca2+, which irreversibly switches calcium signaling from “positive regulation” to “reverse destruction,” leading to cell death. However, this undesirable death could be defined as “calcicoptosis” to offer a novel approach for cancer treatment. Indeed, Ca2+ is involved in various cancer diagnostic and therapeutic events, including calcium overload-induced calcium homeostasis disorder, calcium channels dysregulation, mitochondrial dysfunction, calcium-associated immunoregulation, cell/vascular/tumor calcification, and calcification-mediated CT imaging. In parallel, the development of multifunctional calcium-based nanomaterials (e.g., calcium phosphate, calcium carbonate, calcium peroxide, and hydroxyapatite) is becoming abundantly available. This review will highlight the latest insights of the calcium-based nanomaterials, explain their application, and provide novel perspective. Identifying and characterizing new patterns of calcium-dependent signaling and exploiting the disease element linkage offer additional translational opportunities for cancer theranostics.


Highlights:


1 Recent progress of the calcium-based nanomaterials-mediated cancer diagnosis and therapy were summarized.
2 Main challenges and clinical translation prospects of calcium-based nanomaterials were discussed.

Keywords

Calcium-based nanomaterials Cancer therapy Calcium signaling Tumor calcification Theranostics
Bai, Shuang, Yulu Lan, Shiying Fu, Hongwei Cheng, Zhixiang Lu, and Gang Liu. 2022. “Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy”. Nano-Micro Letters 14 (July):145. https://doi.org/10.1007/s40820-022-00894-6.
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