Issue

Vol. 16 (2024)

Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases

https://doi.org/10.1007/s40820-024-01477-3
Qingdong Bao
State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao 266071, People’s Republic of China
Xiaoting Zhang
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People’s Republic of China
Zhankun Hao
College of Ophthalmology, Shandong First Medical University, Jinan 250000, People’s Republic of China
Qinghua Li
State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao 266071, People’s Republic of China
Fan Wu
College of Ophthalmology, Shandong First Medical University, Jinan 250000, People’s Republic of China
Kaiyuan Wang
Departments of Diagnostic Radiology, Surgery, Chemical and Biomolecular Engineering, and Biomedical Engineering, Yong Loo Lin School of Medicine and College of Design and Engineering, National University of Singapore, Singapore 119074, Singapore
Yang Li
State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, People’s Republic of China
Wenlong Li
State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao 266071, People’s Republic of China
Hua Gao
State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Eye Institute of Shandong First Medical University, Qingdao 266071, People’s Republic of China

Corresponding Author: Hua Gao

hgao@sdfmu.edu.cn

Nano-Micro Letters, Vol. 16 (2024), Article Number: 268

Abstract

The eye, a complex organ isolated from the systemic circulation, presents significant drug delivery challenges owing to its protective mechanisms, such as the blood-retinal barrier and corneal impermeability. Conventional drug administration methods often fail to sustain therapeutic levels and may compromise patient safety and compliance. Polysaccharide-based microneedles (PSMNs) have emerged as a transformative solution for ophthalmic drug delivery. However, a comprehensive review of PSMNs in ophthalmology has not been published to date. In this review, we critically examine the synergy between polysaccharide chemistry and microneedle technology for enhancing ocular drug delivery. We provide a thorough analysis of PSMNs, summarizing the design principles, fabrication processes, and challenges addressed during fabrication, including improving patient comfort and compliance. We also describe recent advances and the performance of various PSMNs in both research and clinical scenarios. Finally, we review the current regulatory frameworks and market barriers that are relevant to the clinical and commercial advancement of PSMNs and provide a final perspective on this research area.


Highlights:
1 Polysaccharide-based microneedles are novel and emerging tools for ocular drug delivery and the research on the diagnosis and treatment of eye diseases is advancing at a fast pace.
2 Microneedle devices constructed from polysaccharide molecules derived from ocular tissue have the potential to significantly enhance the efficiency of clinical treatments and improve patient compliance with therapeutic regimens.
3 Guided by our vast clinical experience, this is the first review collates the cutting-edge scientific findings from the interdisciplinary field combining natural macromolecules and ophthalmology.

Keywords

Ocular delivery Polysaccharide Microneedles Drug administration
Bao, Qingdong, Xiaoting Zhang, Zhankun Hao, Qinghua Li, Fan Wu, Kaiyuan Wang, Yang Li, Wenlong Li, and Hua Gao. 2024. “Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases”. Nano-Micro Letters 16 (August):268. https://doi.org/10.1007/s40820-024-01477-3.
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References
  1. J. Li, R. Ge, K. Lin, J. Wang, Y. He et al., Advances in the application of microneedles in the treatment of local organ diseases. Small 20, 2306222 (2024). https://doi.org/10.1002/smll.202306222
  2. L.K. Vora, A.H. Sabri, P.E. McKenna, A. Himawan, A.R.J. Hutton et al., Microneedle-based biosensing. Nat. Rev. Bioeng. 2, 64–81 (2024). https://doi.org/10.1038/s44222-023-00108-7
  3. K. Glover, D. Mishra, S. Gade, L.K. Vora, Y. Wu et al., Microneedles for advanced ocular drug delivery. Adv. Drug Deliv. Rev. 201, 115082 (2023). https://doi.org/10.1016/j.addr.2023.115082
  4. M. Zheng, T. Sheng, J. Yu, Z. Gu, C. Xu, Microneedle biomedical devices. Nat. Rev. Bioeng. 2, 324–342 (2023). https://doi.org/10.1038/s44222-023-00141-6
  5. Y.N. Ertas, D. Ertas, A. Erdem, F. Segujja, S. Dulchavsky et al., Diagnostic, therapeutic, and theranostic multifunctional microneedles. Small (2024). https://doi.org/10.1002/smll.202308479
  6. H. Chopra, Priyanka, O.P. Choudhary, T.B. Emran, Microneedles for ophthalmic drug delivery: recent developments. Int. J. Surg. 109, 551–552 (2023). https://doi.org/10.1097/JS9.0000000000000133
  7. X. Tang, J. Liu, R. Yan, Q. Peng, Carbohydrate polymer-based bioadhesive formulations and their potentials for the treatment of ocular diseases: a review. Int. J. Biol. Macromol. 242, 124902 (2023). https://doi.org/10.1016/j.ijbiomac.2023.124902
  8. T. Moniz, S.A. Costa Lima, S. Reis, Marine polymeric microneedles for transdermal drug delivery. Carbohyd. Polym. 266, 118098 (2021). https://doi.org/10.1016/j.carbpol.2021.118098
  9. F. Damiri, N. Kommineni, S.O. Ebhodaghe, R. Bulusu, V. Jyothi et al., Microneedle-based natural polysaccharide for drug delivery systems (DDS): progress and challenges. Pharmaceuticals 15, 190 (2022). https://doi.org/10.3390/ph15020190
  10. R. Day, Polysaccharides in ocular tissue*. Am. J. Ophthalmol. 33, 224–226 (1950). https://doi.org/10.1016/0002-9394(50)90840-3
  11. S. Dou, Q. Wang, B. Zhang, C. Wei, H. Wang et al., Single-cell atlas of keratoconus corneas revealed aberrant transcriptional signatures and implicated mechanical stretch as a trigger for keratoconus pathogenesis. Cell Discov. 8, 66 (2022). https://doi.org/10.1038/s41421-022-00397-z
  12. A.S. Monzel, M. Levin, M. Picard, The energetics of cellular life transitions. Life Metab. 3, load051 (2024). https://doi.org/10.1093/lifemeta/load051
  13. N.S. Chandra, S. Gorantla, S. Priya, G. Singhvi, Insight on updates in polysaccharides for ocular drug delivery. Carbohyd. Polym. 297, 120014 (2022). https://doi.org/10.1016/j.carbpol.2022.120014
  14. J. Pushpamalar, P. Meganathan, H.L. Tan, N.A. Dahlan, L.-T. Ooi et al., Development of a polysaccharide-based hydrogel drug delivery system (DDS): an update. Gels 7, 153 (2021). https://doi.org/10.3390/gels7040153
  15. R.A. Armstrong, R.P. Cubbidge, Chapter 1 - the eye and vision: an overview, in Handbook of Nutrition, Diet and the Eye. ed. by V.R. Preedy (Academic Press, San Diego, 2014), pp.3–9
  16. -eye: anatomy, physiology and barriers to drug delivery, in Ocular Transporters and Receptors. ed. by K. Cholkar, S.R. Dasari, D. Pal, and A.K. Mitra (Woodhead Publishing, 2013), pp.1–36
  17. C.E. Willoughby, D. Ponzin, S. Ferrari, A. Lobo, K. Landau et al., Anatomy and physiology of the human eye: effects of mucopolysaccharidoses disease on structure and function—a review. Clin. Exp. Ophthalmol. 38, 2–11 (2010). https://doi.org/10.1111/j.1442-9071.2010.02363.x
  18. B. Chakrabarti, J.W. Park, E.S. Stevens, Glycosaminoglycans: structure and interactio. Crit. Rev. Biochem. Mol. Biol. 8, 225–313 (1980). https://doi.org/10.3109/10409238009102572
  19. M. Zako, M. Yoneda, Chapter 8-functional glycosaminoglycans in the eye, in Carbohydrate Chemistry, Biology and Medical Applications. ed. by H.G. Garg, M.K. Cowman, C.A. Hales (Elsevier, Oxford, 2008), pp.181–208
  20. S. Puri, Y.M. Coulson-Thomas, T.F. Gesteira, V.J. Coulson-Thomas, Distribution and function of glycosaminoglycans and proteoglycans in the development, homeostasis and pathology of the ocular surface. Front. Cell Dev. Biol. 8, 731 (2020). https://doi.org/10.3389/fcell.2020.00731
  21. C.T. Mörner, Untersuchung der proteїnsubstanzen in den leichtbrechenden medien des auges i. Biol. Chem. 18, 61–106 (1894). https://doi.org/10.1515/bchm1.1894.18.1.61
  22. K. Meyer, J.W. Palmer, The polysaccharide of the vitreous humor. J. Biol. Chem. 107, 629–634 (1934). https://doi.org/10.1016/S0021-9258(18)75338-6
  23. X. Lin, T. Mekonnen, S. Verma, C. Zevallos-Delgado, M. Singh et al., Hyaluronan modulates the biomechanical properties of the cornea. Invest. Ophthalmol. Vis. Sci. 63, 6 (2022). https://doi.org/10.1167/iovs.63.13.6
  24. L. Zhan-feng, S. Han-wen, Progress of the research on chemically modifications of polysaccharide. J Hebei Univ (Nat Sci Ed) 25, 104 (2005). https://doi.org/10.3969/j.issn.1000-1565.2005.01.024
  25. L. Huang, M. Shen, G.A. Morris, J. Xie, Sulfated polysaccharides: immunomodulation and signaling mechanisms. Trends Food Sci. Technol. 92, 1–11 (2019). https://doi.org/10.1016/j.tifs.2019.08.008
  26. M. Inatani, H. Tanihara, Proteoglycans in retina. Prog. Retin. Eye Res. 21, 429–447 (2002). https://doi.org/10.1016/S1350-9462(02)00009-5
  27. K.L. Segars, V. Trinkaus-Randall, Glycosaminoglycans: Roles in wound healing, formation of corneal constructs and synthetic corneas. Ocul. Surf. 30, 85–91 (2023). https://doi.org/10.1016/j.jtos.2023.08.008
  28. E.A. Balazs, G. Armand, Glycosaminoglycans and proteoglycans of ocular tissues, in Glycosaminoglycans and Proteoglycans in Physiological and Pathological Processes of Body Systems. ed. by R.V.R.S. Varma, S. Karger (Karger Publishers, Switzerland, 1982), pp.480–499
  29. A. Tawara, H.H. Varner, J.G. Hollyfield, Distribution and characterization of sulfated proteoglycans in the human trabecular tissue. Invest. Ophthalmol. Vis. Sci. 30, 2215–2231 (1989). PMID: 2793361.
  30. D.M. Snow, M. Watanabe, P.C. Letourneau, J. Silver, A chondroitin sulfate proteoglycan may influence the direction of retinal ganglion cell outgrowth. Development 113, 1473–1485 (1991). https://doi.org/10.1242/dev.113.4.1473
  31. Z. Zhuola, S. Barrett, Y.A. Kharaz, R. Akhtar, Nanostructural and mechanical changes in the sclera following proteoglycan depletion. Model. Artif. Intell. Ophthalmol. 2, 14–17 (2018). https://doi.org/10.35119/maio.v2i2.65
  32. J.A. Rada, V.R. Achen, S. Penugonda, R.W. Schmidt, B.A. Mount, Proteoglycan composition in the human sclera during growth and aging. Invest. Ophthalmol. Vis. Sci. 41, 1639–1648 (2000). PMID: 10845580.
  33. J.A. Summers, The sclera and its role in regulation of the refractive state, in Pathologic Myopia. ed. by R.F. Spaide, K. Ohno-Matsui, L.A. Yannuzzi (Springer, Cham, 2021), pp.87–104. https://doi.org/10.1007/978-3-030-74334-5_7
  34. J.A. Rada, V.R. Achen, C.A. Perry, P.W. Fox, Proteoglycans in the human sclera. Evidence for the presence of aggrecan. Invest. Ophthalmol. Vis. Sci. 38, 1740–1751 (1997). PMID: 9286262.
  35. N. Jabeen, M. Atif, Polysaccharides based biopolymers for biomedical applications: a review. Polym. Adv. Technol. 35, e6203 (2024). https://doi.org/10.1002/pat.6203
  36. Y. Yu, M. Shen, Q. Song, J. Xie, Biological activities and pharmaceutical applications of polysaccharide from natural resources: a review. Carbohyd. Polym. 183, 91–101 (2018). https://doi.org/10.1016/j.carbpol.2017.12.009
  37. M. Kenchegowda, U. Hani, A. Al Fatease, N. Haider, K. Ramesh et al., Tiny titans-unravelling the potential of polysaccharides and proteins based dissolving microneedles in drug delivery and theranostics: a comprehensive review. Int. J. Biol. Macromol. 253, 127172 (2023). https://doi.org/10.1016/j.ijbiomac.2023.127172
  38. D.F.S. Fonseca, C. Vilela, A.J.D. Silvestre, C.S.R. Freire, A compendium of current developments on polysaccharide and protein-based microneedles. Int. J. Biol. Macromol. 136, 704–728 (2019). https://doi.org/10.1016/j.ijbiomac.2019.04.163
  39. R.S. Bhadale, V.Y. Londhe, A systematic review of carbohydrate-based microneedles: current status and future prospects. J. Mater. Sci. Mater. Med. 32, 89 (2021). https://doi.org/10.1007/s10856-021-06559-x
  40. A.I. Barbosa, F. Serrasqueiro, T. Moniz, S.A. Costa Lima, S. Reis, Marine polysaccharides for skin drug delivery: hydrogels and microneedle solutions, in Marine Biomaterials: Drug Delivery and Therapeutic Applications. ed. by S. Jana, S. Jana (Springer Nature Singapore, Singapore, 2022), pp.209–250
  41. P. Snetkov, K. Zakharova, S. Morozkina, R. Olekhnovich, M. Uspenskaya, Hyaluronic acid: the influence of molecular weight on structural, physical, physico-chemical, and degradable properties of biopolymer. Polymers 12, 1800 (2020). https://doi.org/10.3390/polym12081800
  42. I. Saha, V.K. Rai, Hyaluronic acid based microneedle array: recent applications in drug delivery and cosmetology. Carbohyd. Polym. 267, 118168 (2021). https://doi.org/10.1016/j.carbpol.2021.118168
  43. H. Kang, Z. Zuo, R. Lin, M. Yao, Y. Han et al., The most promising microneedle device: present and future of hyaluronic acid microneedle patch. Drug Deliv. 29, 3087–3110 (2022). https://doi.org/10.1080/10717544.2022.2125600
  44. H. Shi, S. Huai, H. Wei, Y. Xu, L. Lei et al., Dissolvable hybrid microneedle patch for efficient delivery of curcumin to reduce intraocular inflammation. Int. J. Pharm. 643, 123205 (2023). https://doi.org/10.1016/j.ijpharm.2023.123205
  45. Y. Jiang, Y. Jin, C. Feng, Y. Wu, W. Zhang et al., Engineering hyaluronic acid microneedles loaded with Mn2+ and temozolomide for topical precision therapy of melanoma. Adv. Healthc. Mater. 13, e2303215 (2023). https://doi.org/10.1002/adhm.202303215
  46. J.H. Tay, Y.H. Lim, M. Zheng, Y. Zhao, W.S. Tan et al., Development of hyaluronic acid-silica composites via in situ precipitation for improved penetration efficiency in fast-dissolving microneedle systems. Acta Biomater. 172, 175–187 (2023). https://doi.org/10.1016/j.actbio.2023.10.016
  47. Y. Wu, L.K. Vora, R.F. Donnelly, T.R.R. Singh, Rapidly dissolving bilayer microneedles enabling minimally invasive and efficient protein delivery to the posterior segment of the eye. Drug Deliv. Transl. Res. 13, 2142–2158 (2023). https://doi.org/10.1007/s13346-022-01190-x
  48. G. Bonfante, H. Lee, L. Bao, J. Park, N. Takama et al., Comparison of polymers to enhance mechanical properties of microneedles for bio-medical applications. Micro Nano Syst. Lett. 8, 1–13 (2020). https://doi.org/10.1186/s40486-020-00113-0
  49. S. Zhang, L. Yang, S. Hong, J. Liu, J. Cheng et al., Collagen type I–loaded methacrylamide hyaluronic acid hydrogel microneedles alleviate stress urinary incontinence in mice: a novel treatment and prevention strategy. Colloids Surf. B Biointerfaces 222, 113085 (2023). https://doi.org/10.1016/j.colsurfb.2022.113085
  50. A. Than, C. Liu, H. Chang, P.K. Duong, C.M.G. Cheung et al., Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery. Nat. Commun. 9, 4433 (2018). https://doi.org/10.1038/s41467-018-06981-w
  51. S. Baek, K.P. Lee, C.S. Han, S.H. Kwon, S.J. Lee, Hyaluronic acid-based biodegradable microneedles loaded with epidermal growth factor for treatment of diabetic foot. Macromol. Res. 32, 13–22 (2024). https://doi.org/10.1007/s13233-023-00206-w
  52. B. Wang, W. Zhang, Q. Pan, J. Tao, S. Li et al., Hyaluronic acid-based CuS nanoenzyme biodegradable microneedles for treating deep cutaneous fungal infection without drug resistance. Nano Lett. 23, 1327–1336 (2023). https://doi.org/10.1021/acs.nanolett.2c04539
  53. Y. Yu, Y. Gao, Y. Zeng, W. Ge, C. Tang et al., Multifunctional hyaluronic acid/gelatin methacryloyl core-shell microneedle for comprehensively treating oral mucosal ulcers. Int. J. Biol. Macromol. 266, 131221 (2024). https://doi.org/10.1016/j.ijbiomac.2024.131221
  54. S.M. Whitcup, M.R. Robinson, Development of a dexamethasone intravitreal implant for the treatment of noninfectious posterior segment uveitis. Ann. N. Y. Acad. Sci. 1358, 1–12 (2015). https://doi.org/10.1111/nyas.12824
  55. P. Suriyaamporn, P. Opanasopit, T. Ngawhirunpat, W. Rangsimawong, Computer-aided rational design for optimally Gantrez® S-97 and hyaluronic acid-based dissolving microneedles as a potential ocular delivery system. J. Drug Deliv. Sci. Technol. 61, 102319 (2021). https://doi.org/10.1016/j.jddst.2020.102319
  56. H. Shi, J. Zhou, Y. Wang, Y. Zhu, D. Lin et al., A rapid corneal healing microneedle for efficient ocular drug delivery. Small 18, 2104657 (2022). https://doi.org/10.1002/smll.202104657
  57. S. Juhng, J. Song, J. You, J. Park, H. Yang et al., Fabrication of liraglutide-encapsulated triple layer hyaluronic acid microneedles (TLMs) for the treatment of obesity. Lab Chip 23, 2378–2388 (2023). https://doi.org/10.1039/d2lc01084d
  58. Y. Li, J. Lin, P. Wang, F. Zhu, M. Wu et al., Tumor microenvironment-responsive yolk–shell NaCl@virus-inspired tetrasulfide-organosilica for ion-interference therapy via osmolarity surge and oxidative stress amplification. ACS Nano 16, 7380–7397 (2022). https://doi.org/10.1021/acsnano.1c09496
  59. Y. Shi, M. Yu, K. Qiu, T. Kong, C. Guo et al., Immuno-modulation of tumor and tumor draining lymph nodes through enhanced immunogenic chemotherapy by nano-complexed hyaluronic acid/polyvinyl alcohol microneedle. Carbohyd. Polym. 325, 121491 (2024). https://doi.org/10.1016/j.carbpol.2023.121491
  60. Y. Li, J. Lin, P. Wang, Q. Luo, H. Lin et al., Tumor microenvironment responsive shape-reversal self-targeting virus-inspired nanodrug for imaging-guided near-infrared-II photothermal chemotherapy. ACS Nano 13, 12912–12928 (2019). https://doi.org/10.1021/acsnano.9b05425
  61. J. Yang, Z. Chu, Y. Jiang, W. Zheng, J. Sun et al., Multifunctional hyaluronic acid microneedle patch embedded by cerium/zinc-based composites for accelerating diabetes wound healing. Adv. Healthc. Mater. 12, 2300725 (2023). https://doi.org/10.1002/adhm.202300725
  62. S. Liu, Q. Bai, Y. Jiang, Y. Gao, Z. Chen et al., Multienzyme-like nanozyme encapsulated ocular microneedles for keratitis treatment. Small 20, 2308403 (2024). https://doi.org/10.1002/smll.202308403
  63. M. Liang, L. Shang, Y. Yu, Y. Jiang, Q. Bai et al., Ultrasound activatable microneedles for bilaterally augmented sono-chemodynamic and sonothermal antibacterial therapy. Acta Biomater. 158, 811–826 (2023). https://doi.org/10.1016/j.actbio.2022.12.041
  64. S. Shi, Y. Jiang, Y. Yu, M. Liang, Q. Bai et al., Piezo-augmented and photocatalytic nanozyme integrated microneedles for antibacterial and anti-inflammatory combination therapy. Adv. Funct. Mater. 33, 2210850 (2023). https://doi.org/10.1002/adfm.202210850
  65. N. Dabholkar, S. Gorantla, T. Waghule, V.K. Rapalli, A. Kothuru et al., Biodegradable microneedles fabricated with carbohydrates and proteins: revolutionary approach for transdermal drug delivery. Int. J. Biol. Macromol. 170, 602–621 (2021). https://doi.org/10.1016/j.ijbiomac.2020.12.177
  66. W. Du, X. Li, M. Zhang, G. Ling, P. Zhang, Investigation of the antibacterial properties of hyaluronic acid microneedles based on chitosan and MoS2. J. Mater. Chem. B 11, 7169–7181 (2023). https://doi.org/10.1039/D3TB00755C
  67. A. Chandrasekharan, Y.J. Hwang, K.Y. Seong, S. Park, S. Kim et al., Acid-treated water-soluble chitosan suitable for microneedle-assisted intracutaneous drug delivery. Pharmaceutics 11, 209 (2019). https://doi.org/10.3390/pharmaceutics11050209
  68. Y. Yang, S. Wang, Y. Wang, X. Wang, Q. Wang et al., Advances in self-assembled chitosan nanomaterials for drug delivery. Biotechnol. Adv. 32, 1301–1316 (2014). https://doi.org/10.1016/j.biotechadv.2014.07.007
  69. D.A. Castilla-Casadiego, K.A. Miranda-Muñoz, J.L. Roberts, A.D. Crowell, D. Gonzalez-Nino et al., Biodegradable microneedle patch for delivery of meloxicam for managing pain in cattle. PLoS ONE 17, e0272169 (2022). https://doi.org/10.1371/journal.pone.0272169
  70. A. Zamboulis, S. Nanaki, G. Michailidou, I. Koumentakou, M. Lazaridou et al., Chitosan and its derivatives for ocular delivery formulations: recent advances and developments. Polymers 12, 1519 (2020). https://doi.org/10.3390/polym12071519
  71. M.-C. Chen, M.-H. Ling, K.-Y. Lai, E. Pramudityo, Chitosan microneedle patches for sustained transdermal delivery of macromolecules. Biomacromol 13, 4022–4031 (2012). https://doi.org/10.1021/bm301293d
  72. C. Ryall, S. Chen, S. Duarah, J. Wen, Chitosan-based microneedle arrays for dermal delivery of Centella asiatica. Int. J. Pharm. 627, 122221 (2022). https://doi.org/10.1016/j.ijpharm.2022.122221
  73. D.A. Castilla-Casadiego, H. Carlton, D. Gonzalez-Nino, K.A. Miranda-Muñoz, R. Daneshpour et al., Design, characterization, and modeling of a chitosan microneedle patch for transdermal delivery of meloxicam as a pain management strategy for use in cattle. Mater. Sci. Eng. C 118, 111544 (2021). https://doi.org/10.1016/j.msec.2020.111544
  74. P. Suriyaamporn, P. Opanasopit, W. Rangsimawong, T. Ngawhirunpat, Optimal design of novel microemulsions-based two-layered dissolving microneedles for delivering fluconazole in treatment of fungal eye infection. Pharmaceutics 14, 472 (2022). https://doi.org/10.3390/pharmaceutics14030472
  75. S. Manna, R.K. Banerjee, J.J. Augsburger, M.F. Al-Rjoub, A. Donnell et al., Biodegradable chitosan and polylactic acid-based intraocular micro-implant for sustained release of methotrexate into vitreous: analysis of pharmacokinetics and toxicity in rabbit eyes. Graefes Arch. Clin. Exp. Ophthalmol. 253, 1297–1305 (2015). https://doi.org/10.1007/s00417-015-3007-1
  76. L. Popa, M.V. Ghica, C.E. Dinu-Pîrvu, T. Irimia, Chitosan: A good candidate for sustained release ocular drug delivery systems, in Chitin-Chitosan—Myriad Functionalities in Science and Technology. (InTech, London, UK, 2018), pp.283–310. https://doi.org/10.5772/intechopen.76039
  77. W. Li, E.S. Thian, M. Wang, Z. Wang, L. Ren, Surface design for antibacterial materials: from fundamentals to advanced strategies. Adv. Sci. 8, 2100368 (2021). https://doi.org/10.1002/advs.202100368
  78. W. Li, H. Chen, J. Cai, M. Wang, X. Zhou et al., Poly (pentahydropyrimidine)-based hybrid hydrogel with synergistic antibacterial and pro-angiogenic ability for the therapy of diabetic foot ulcers. Adv. Funct. Mater. 33, 2303147 (2023). https://doi.org/10.1002/adfm.202303147
  79. W. Li, J. Cai, W. Zhou, X. Zhao, M. Wang et al., Poly (aspartic acid)-based self-healing hydrogel with precise antibacterial ability for rapid infected-wound repairing. Colloids Surf. B Biointerfaces 221, 112982 (2023). https://doi.org/10.1016/j.colsurfb.2022.112982
  80. J. Chi, X. Zhang, C. Chen, C. Shao, Y. Zhao et al., Antibacterial and angiogenic chitosan microneedle array patch for promoting wound healing. Bioact. Mater. 5, 253–259 (2020). https://doi.org/10.1016/j.bioactmat.2020.02.004
  81. S.R. Pardeshi, M.P. More, C.V. Pardeshi, P.J. Chaudhari, A.D. Gholap et al., Novel crosslinked nanops of chitosan oligosaccharide and dextran sulfate for ocular administration of dorzolamide against glaucoma. J. Drug Deliv. Sci. Technol. 86, 104719 (2023). https://doi.org/10.1016/j.jddst.2023.104719
  82. A. Kumari, P.K. Sharma, V.K. Garg, G. Garg, Ocular inserts—advancement in therapy of eye diseases. J. Adv. Pharm. Technol. Res. 1, 291–296 (2010). https://doi.org/10.4103/0110-5558.72419
  83. R. Yuan, N. Yang, Y. Huang, W. Li, Y. Zeng et al., Layer-by-layer microneedle-mediated rhEGF transdermal delivery for enhanced wound epidermal regeneration and angiogenesis. ACS Appl. Mater. Interfaces 15, 21929–21940 (2023). https://doi.org/10.1021/acsami.3c02254
  84. Z. Chen, Y. Zhang, K. Feng, T. Hu, B. Huang et al., Facile fabrication of quaternized chitosan-incorporated biomolecular patches for non-compressive haemostasis and wound healing. Fundam. Res. (2023). https://doi.org/10.1016/j.fmre.2023.05.009
  85. H. Wei, S. Liu, Z. Tong, T. Chen, M. Yang et al., Hydrogel-based microneedles of chitosan derivatives for drug delivery. React. Funct. Polym. 172, 105200 (2022). https://doi.org/10.1016/j.reactfunctpolym.2022.105200
  86. E. Díaz-Montes, Dextran: sources, structures, and properties. Polysaccharides 2, 554–565 (2021). https://doi.org/10.3390/polysaccharides2030033
  87. S. Huang, H. Liu, S. Huang, T. Fu, W. Xue et al., Dextran methacrylate hydrogel microneedles loaded with doxorubicin and trametinib for continuous transdermal administration of melanoma. Carbohyd. Polym. 246, 116650 (2020). https://doi.org/10.1016/j.carbpol.2020.116650
  88. J. Liang, Y. Yu, C. Li, Q. Li, P. Chen et al., Tofacitinib combined with melanocyte protector α-MSH to treat vitiligo through dextran based hydrogel microneedles. Carbohyd. Polym. 305, 120549 (2023). https://doi.org/10.1016/j.carbpol.2023.120549
  89. S. Fakhraei Lahiji, Y. Jang, I. Huh, H. Yang, M. Jang et al., Exendin-4–encapsulated dissolving microneedle arrays for efficient treatment of type 2 diabetes. Sci. Rep. 8, 1170 (2018). https://doi.org/10.1038/s41598-018-19789-x
  90. J. Leelawattanachai, K. Panyasu, K. Prasertsom, S. Manakasettharn, H. Duangdaw et al., Highly stable and fast-dissolving ascorbic acid-loaded microneedles. Int. J. Cosmet. Sci. 45, 612–626 (2023). https://doi.org/10.1111/ics.12865
  91. H. Liu, B. Wang, M. Xing, F. Meng, S. Zhang et al., Thermal stability of exenatide encapsulated in stratified dissolving microneedles during storage. Int. J. Pharm. 636, 122863 (2023). https://doi.org/10.1016/j.ijpharm.2023.122863
  92. A.S. Bernd, M. Aihara, J.D. Lindsey, R.N. Weinreb, Influence of molecular weight on intracameral dextran movement to the posterior segment of the mouse eye. Invest. Ophthalmol. Vis. Sci. 45, 480–484 (2004). https://doi.org/10.1167/iovs.03-0462
  93. J.-S. Yang, Y.-J. Xie, W. He, Research progress on chemical modification of alginate: a review. Carbohyd. Polym. 84, 33–39 (2011). https://doi.org/10.1016/j.carbpol.2010.11.048
  94. X. Mei, Y. Chang, J. Shen, Y. Zhang, C. Xue, Expression and characterization of a novel alginate-binding protein: a promising tool for investigating alginate. Carbohyd. Polym. 246, 116645 (2020). https://doi.org/10.1016/j.carbpol.2020.116645
  95. D. Al Sulaiman, J.Y. Chang, N.R. Bennett, H. Topouzi, C.A. Higgins et al., Hydrogel-coated microneedle arrays for minimally invasive sampling and sensing of specific circulating nucleic acids from skin interstitial fluid. ACS Nano 13, 9620–9628 (2019). https://doi.org/10.1021/acsnano.9b04783
  96. C.V. Liew, L.W. Chan, A.L. Ching, P.W.S. Heng, Evaluation of sodium alginate as drug release modifier in matrix tablets. Int. J. Pharm. 309, 25–37 (2006). https://doi.org/10.1016/j.ijpharm.2005.10.040
  97. P. Agulhon, M. Robitzer, L. David, F. Quignard, Structural regime identification in ionotropic alginate gels: influence of the cation nature and alginate structure. Biomacromol 13, 215–220 (2012). https://doi.org/10.1021/bm201477g
  98. Y. Zhang, G. Jiang, W. Yu, D. Liu, B. Xu, Microneedles fabricated from alginate and maltose for transdermal delivery of insulin on diabetic rats. Mater. Sci. Eng. C 85, 18–26 (2018). https://doi.org/10.1016/j.msec.2017.12.006
  99. Y.K. Demir, Z. Akan, O. Kerimoglu, Sodium alginate microneedle arrays mediate the transdermal delivery of bovine serum albumin. PLoS ONE 8, e63819 (2013). https://doi.org/10.1371/journal.pone.0063819
  100. T. Tiraton, O. Suwantong, P. Chuysinuan, P. Ekabutr, P. Niamlang et al., Biodegradable microneedle fabricated from sodium alginate-gelatin for transdermal delivery of clindamycin. Mater. Today Commun. 32, 104158 (2022). https://doi.org/10.1016/j.mtcomm.2022.104158
  101. Z. Zhou, M. Xing, S. Zhang, G. Yang, Y. Gao, Process optimization of Ca2+ cross-linked alginate-based swellable microneedles for enhanced transdermal permeability: more applicable to acidic drugs. Int. J. Pharm. 618, 121669 (2022). https://doi.org/10.1016/j.ijpharm.2022.121669
  102. W. Yu, G. Jiang, Y. Zhang, D. Liu, B. Xu et al., Polymer microneedles fabricated from alginate and hyaluronate for transdermal delivery of insulin. Mater. Sci. Eng. C 80, 187–196 (2017). https://doi.org/10.1016/j.msec.2017.05.143
  103. R. Jia, C. Cui, L. Gao, Y. Qin, N. Ji et al., A review of starch swelling behavior: its mechanism, determination methods, influencing factors, and influence on food quality. Carbohyd. Polym. 321, 121260 (2023). https://doi.org/10.1016/j.carbpol.2023.121260
  104. Y. Zhang, M. Wu, D. Tan, Q. Liu, R. Xia et al., A dissolving and glucose-responsive insulin-releasing microneedle patch for type 1 diabetes therapy. J. Mater. Chem. B 9, 648–657 (2021). https://doi.org/10.1039/d0tb02133d
  105. R.S. Singh, N. Kaur, V. Rana, J.F. Kennedy, Pullulan: a novel molecule for biomedical applications. Carbohyd. Polym. 171, 102–121 (2017). https://doi.org/10.1016/j.carbpol.2017.04.089
  106. S. Tiwari, R. Patil, S.K. Dubey, P. Bahadur, Derivatization approaches and applications of pullulan. Adv. Colloid Interfaces Sci. 269, 296–308 (2019). https://doi.org/10.1016/j.cis.2019.04.014
  107. R.S. Singh, N. Kaur, M. Hassan, J.F. Kennedy, Pullulan in biomedical research and development-a review. Int. J. Biol. Macromol. 166, 694–706 (2021). https://doi.org/10.1016/j.ijbiomac.2020.10.227
  108. L.K. Vora, A.J. Courtenay, I.A. Tekko, E. Larrañeta, R.F. Donnelly, Pullulan-based dissolving microneedle arrays for enhanced transdermal delivery of small and large biomolecules. Int. J. Biol. Macromol. 146, 290–298 (2020). https://doi.org/10.1016/j.ijbiomac.2019.12.184
  109. R.S. Singh, N. Kaur, D. Singh, S.S. Purewal, J.F. Kennedy, Pullulan in pharmaceutical and cosmeceutical formulations: a review. Int. J. Biol. Macromol. 231, 123353 (2023). https://doi.org/10.1016/j.ijbiomac.2023.123353
  110. D.F.S. Fonseca, P.C. Costa, I.F. Almeida, P. Dias-Pereira, I. Correia-Sá et al., Pullulan microneedle patches for the efficient transdermal administration of insulin envisioning diabetes treatment. Carbohyd. Polym. 241, 116314 (2020). https://doi.org/10.1016/j.carbpol.2020.116314
  111. W. Cheng, Y. Zhu, G. Jiang, K. Cao, S. Zeng et al., Sustainable cellulose and its derivatives for promising biomedical applications. Prog. Mater. Sci. 138, 101152 (2023). https://doi.org/10.1016/j.pmatsci.2023.101152
  112. A.C.Q. Silva, B. Pereira, N.S. Lameirinhas, P.C. Costa, I.F. Almeida et al., Dissolvable carboxymethylcellulose microneedles for noninvasive and rapid administration of diclofenac sodium. Macromol. Biosci. 23, 2200323 (2023). https://doi.org/10.1002/mabi.202200323
  113. A.A. Seetharam, H. Choudhry, M.A. Bakhrebah, W.H. Abdulaal, M.S. Gupta et al., Microneedles drug delivery systems for treatment of cancer: a recent update. Pharmaceutics 12, 1101 (2020). https://doi.org/10.3390/pharmaceutics12111101
  114. T. Aziz, A. Farid, F. Haq, M. Kiran, A. Ullah et al., A review on the modification of cellulose and its applications. Polymers 14, 3206 (2022). https://doi.org/10.3390/polym14153206
  115. J.-Y. Kim, M.-R. Han, Y.-H. Kim, S.-W. Shin, S.-Y. Nam et al., Tip-loaded dissolving microneedles for transdermal delivery of donepezil hydrochloride for treatment of Alzheimer’s disease. Eur. J. Pharm. Biopharm. 105, 148–155 (2016). https://doi.org/10.1016/j.ejpb.2016.06.006
  116. X. Lan, W. Zhu, X. Huang, Y. Yu, H. Xiao et al., Microneedles loaded with anti-PD-1–cisplatin nanops for synergistic cancer immuno-chemotherapy. Nanoscale 12, 18885–18898 (2020). https://doi.org/10.1039/d0nr04213g
  117. J.W. Lee, S.-O. Choi, E.I. Felner, M.R. Prausnitz, Dissolving microneedle patch for transdermal delivery of human growth hormone. Small 7, 531–539 (2011). https://doi.org/10.1002/smll.201001091
  118. Y.-H. Park, S.K. Ha, I. Choi, K.S. Kim, J. Park et al., Fabrication of degradable carboxymethyl cellulose (CMC) microneedle with laser writing and replica molding process for enhancement of transdermal drug delivery. Biotechnol. Bioeng. 21, 110–118 (2016). https://doi.org/10.1007/s12257-015-0634-7
  119. N. Qiang, Z. Liu, M. Lu, Y. Yang, F. Liao et al., Preparation and properties of polyvinylpyrrolidone/sodium carboxymethyl cellulose soluble microneedles. Materials 16, 3417 (2023). https://doi.org/10.3390/ma16093417
  120. R. Sharma, K. Kuche, P. Thakor, V. Bhavana, S. Srivastava et al., Chondroitin sulfate: emerging biomaterial for biopharmaceutical purpose and tissue engineering. Carbohyd. Polym. 286, 119305 (2022). https://doi.org/10.1016/j.carbpol.2022.119305
  121. J. Yu, Y. Xia, H. Zhang, X. Pu, T. Gong et al., A semi-interpenetrating network-based microneedle for rapid local anesthesia. J. Drug Deliv. Sci. Technol. 78, 103984 (2022). https://doi.org/10.1016/j.jddst.2022.103984
  122. M.M. Abdallah, N. Fernández, A.A. Matias, M. de Rosário Bronze, Hyaluronic acid and chondroitin sulfate from marine and terrestrial sources: extraction and purification methods. Carbohyd. Polym. 243, 116441 (2020). https://doi.org/10.1016/j.carbpol.2020.116441
  123. S. Liu, S. Zhang, Y. Duan, Y. Niu, H. Gu et al., Transcutaneous immunization of recombinant staphylococcal enterotoxin B protein using a dissolving microneedle provides potent protection against lethal enterotoxin challenge. Vaccine 37, 3810–3819 (2019). https://doi.org/10.1016/j.vaccine.2019.05.055
  124. K. Fukushima, A. Ise, H. Morita, R. Hasegawa, Y. Ito et al., Two-layered dissolving microneedles for percutaneous delivery of peptide/protein drugs in rats. Pharm. Res. 28, 7–21 (2011). https://doi.org/10.1007/s11095-010-0097-7
  125. D. Poirier, F. Renaud, V. Dewar, L. Strodiot, F. Wauters et al., Hepatitis B surface antigen incorporated in dissolvable microneedle array patch is antigenic and thermostable. Biomaterials 145, 256–265 (2017). https://doi.org/10.1016/j.biomaterials.2017.08.038
  126. K. Gou, Y. Li, Y. Qu, H. Li, R. Zeng, Advances and prospects of Bletilla striata polysaccharide as promising multifunctional biomedical materials. Mater. Des. 223, 111198 (2022). https://doi.org/10.1016/j.matdes.2022.111198
  127. Z. Chen, L. Cheng, Y. He, X. Wei, Extraction, characterization, utilization as wound dressing and drug delivery of Bletilla striata polysaccharide: a review. Int. J. Biol. Macromol. 120, 2076–2085 (2018). https://doi.org/10.1016/j.ijbiomac.2018.09.028
  128. L. Bai, T. Wang, Q. Deng, W. Zheng, X. Li et al., Dual properties of pharmacological activities and preparation excipient: Bletilla striata polysaccharides. Int. J. Biol. Macromol. (2023). https://doi.org/10.1016/j.ijbiomac.2023.127643
  129. L. Hu, Z. Liao, Q. Hu, K.G. Maffucci, Y. Qu, Novel Bletilla striata polysaccharide microneedles: fabrication, characterization, and in vitro transcutaneous drug delivery. Int. J. Biol. Macromol. 117, 928–936 (2018). https://doi.org/10.1016/j.ijbiomac.2018.05.097
  130. M.K. Chan, Y. Yu, S. Wulamu, Y. Wang, Q. Wang et al., Structural analysis of water-soluble polysaccharides isolated from panax notoginseng. Int. J. Biol. Macromol. 155, 376–385 (2020). https://doi.org/10.1016/j.ijbiomac.2020.03.233
  131. C. Wang, S. Liu, J. Xu, M. Gao, Y. Qu et al., Dissolvable microneedles based on panax notoginseng polysaccharide for transdermal drug delivery and skin dendritic cell activation. Carbohyd. Polym. 268, 118211 (2021). https://doi.org/10.1016/j.carbpol.2021.118211
  132. R.F. Donnelly, D.I. Morrow, T.R. Singh, K. Migalska, P.A. McCarron et al., Processing difficulties and instability of carbohydrate microneedle arrays. Drug Dev. Ind. Pharm. 35, 1242–1254 (2009). https://doi.org/10.1080/03639040902882280
  133. M.J. Mistilis, J.C. Joyce, E.S. Esser, I. Skountzou, R.W. Compans et al., Long-term stability of influenza vaccine in a dissolving microneedle patch. Drug Deliv. Transl. Res. 7, 195–205 (2017). https://doi.org/10.1007/s13346-016-0282-2
  134. L. Yenkoidiok-Douti, C. Barillas-Mury, C.M. Jewell, Design of dissolvable microneedles for delivery of a Pfs47-based malaria transmission-blocking vaccine. ACS Biomater. Sci. Eng. 7, 1854–1862 (2021). https://doi.org/10.1021/acsbiomaterials.0c01363
  135. L.Y. Chu, L. Ye, K. Dong, R.W. Compans, C. Yang et al., Enhanced stability of inactivated influenza vaccine encapsulated in dissolving microneedle patches. Pharm. Res. 33, 868–878 (2016). https://doi.org/10.1007/s11095-015-1833-9
  136. D.D. Zhu, X.P. Zhang, H.L. Yu, R.X. Liu, C.B. Shen et al., Kinetic stability studies of HBV vaccine in a microneedle patch. Int. J. Pharm. 567, 118489 (2019). https://doi.org/10.1016/j.ijpharm.2019.118489
  137. Y. Lee, W. Li, J. Tang, S.P. Schwendeman, M.R. Prausnitz, Immediate detachment of microneedles by interfacial fracture for sustained delivery of a contraceptive hormone in the skin. J. Control. Release 337, 676–685 (2021). https://doi.org/10.1016/j.jconrel.2021.08.012
  138. A. Kumar, K.M. Rao, S.S. Han, Application of xanthan gum as polysaccharide in tissue engineering: a review. Carbohyd. Polym. 180, 128–144 (2018). https://doi.org/10.1016/j.carbpol.2017.10.009
  139. P.S. Gils, D. Ray, P.K. Sahoo, Characteristics of xanthan gum-based biodegradable superporous hydrogel. Int. J. Biol. Macromol. 45, 364–371 (2009). https://doi.org/10.1016/j.ijbiomac.2009.07.007
  140. P. Rakshit, T.K. Giri, K. Mukherjee, Research progresses on carboxymethyl xanthan gum: review of synthesis, physicochemical properties, rheological characterization and applications in drug delivery. Int. J. Biol. Macromol. 266, 131122 (2024). https://doi.org/10.1016/j.ijbiomac.2024.131122
  141. Y. Bachra, A. Grouli, F. Damiri, M. Talbi, M. Berrada, A novel superabsorbent polymer from crosslinked carboxymethyl tragacanth gum with glutaraldehyde: synthesis, characterization, and swelling properties. Int. J. Biomater. 2021, 5008833 (2021). https://doi.org/10.1155/2021/5008833
  142. H.-J. Choi, J.-M. Song, B.J. Bondy, R.W. Compans, S.-M. Kang et al., Effect of osmotic pressure on the stability of whole inactivated influenza vaccine for coating on microneedles. PLoS ONE 10, e0134431 (2015). https://doi.org/10.1371/journal.pone.0134431
  143. H. Xiang, S. Xu, W. Zhang, Y. Li, Y. Zhou et al., Skin permeation of curcumin nanocrystals: effect of p size, delivery vehicles, and permeation enhancer. Colloids Surf. B Biointerfaces 224, 113203 (2023). https://doi.org/10.1016/j.colsurfb.2023.113203
  144. L.-D. Koh, Y. Cheng, C.-P. Teng, Y.-W. Khin, X.-J. Loh et al., Structures, mechanical properties and applications of silk fibroin materials. Prog. Polym. Sci. 46, 86–110 (2015). https://doi.org/10.1016/j.progpolymsci.2015.02.001
  145. E. Wenk, H.P. Merkle, L. Meinel, Silk fibroin as a vehicle for drug delivery applications. J. Control. Release 150, 128–141 (2011). https://doi.org/10.1016/j.jconrel.2010.11.007
  146. J. Lee, E.H. Jang, J.H. Kim, S. Park, Y. Kang et al., Highly flexible and porous silk fibroin microneedle wraps for perivascular drug delivery. J. Control. Release 340, 125–135 (2021). https://doi.org/10.1016/j.jconrel.2021.10.024
  147. M. Zhu, Y. Liu, F. Jiang, J. Cao, S.C. Kundu et al., Combined silk fibroin microneedles for insulin delivery. ACS Biomater. Sci. Eng. 6, 3422–3429 (2020). https://doi.org/10.1021/acsbiomaterials.0c00273
  148. Y. Gao, M. Hou, R. Yang, L. Zhang, Z. Xu et al., Highly porous silk fibroin scaffold packed in PEGDA/sucrose microneedles for controllable transdermal drug delivery. Biomacromol 20, 1334–1345 (2019). https://doi.org/10.1021/acs.biomac.8b01715
  149. Z. Yin, D. Kuang, S. Wang, Z. Zheng, V.K. Yadavalli et al., Swellable silk fibroin microneedles for transdermal drug delivery. Int. J. Biol. Macromol. 106, 48–56 (2018). https://doi.org/10.1016/j.ijbiomac.2017.07.178
  150. M.R. Babu, S. Vishwas, R. Khursheed, V. Harish, A.B. Sravani et al., Unravelling the role of microneedles in drug delivery: principle, perspectives, and practices. Drug Deliv. Transl. Res. 14, 1393–1431 (2023). https://doi.org/10.1007/s13346-023-01475-9
  151. T. Zhu, W. Zhang, P. Jiang, S. Zhou, C. Wang et al., Progress in intradermal and transdermal gene therapy with microneedles. Pharm. Res. 39, 2475–2486 (2022). https://doi.org/10.1007/s11095-022-03376-x
  152. S. Khan, A. Hasan, F. Attar, M.M.N. Babadaei, H.A. Zeinabad et al., Diagnostic and drug release systems based on microneedle arrays in breast cancer therapy. J. Control. Release 338, 341–357 (2021). https://doi.org/10.1016/j.jconrel.2021.08.036
  153. P. Rana, A.D. Dey, T. Agarwal, A. Kumar, Microneedles for delivery of anticancer therapeutics: recent trends and technologies. J. Nanopart. Res. 25, 154 (2023). https://doi.org/10.1007/s11051-023-05803-5
  154. J.Y. Park, Treatment of intraocular lymphoma using biodegradable microneedle implant. 139 (2007). https://europepmc.org//ETH/3418
  155. J. Jiang, H.S. Gill, D. Ghate, B.E. McCarey, S.R. Patel et al., Coated microneedles for drug delivery to the eye. Invest. Ophthalmol. Vis. Sci. 48, 4038–4043 (2007). https://doi.org/10.1167/iovs.07-0066
  156. Y.C. Kim, M.R. Prausnitz, H.F. Edelhauser, Targeted delivery of anti-glaucoma drugs to the supraciliary space using microneedles. Invest. Ophthalmol. Vis. Sci. 55, 5257–5257 (2014). https://doi.org/10.1167/iovs.14-14651
  157. H.B. Song, K.J. Lee, I.H. Seo, J.Y. Lee, S.-M. Lee et al., Impact insertion of transfer-molded microneedle for localized and minimally invasive ocular drug delivery. J. Control. Release 209, 272–279 (2015). https://doi.org/10.1016/j.jconrel.2015.04.041
  158. R.R.S. Thakur, I.A. Tekko, F. Al-Shammari, A.A. Ali, H. McCarthy et al., Rapidly dissolving polymeric microneedles for minimally invasive intraocular drug delivery. Drug Deliv. Transl. Res. 6, 800–815 (2016). https://doi.org/10.1007/s13346-016-0332-9
  159. M. Amer, R.K. Chen, Self-adhesive microneedles with interlocking features for sustained ocular drug delivery. Macromol. Biosci. 20, 2000089 (2020). https://doi.org/10.1002/mabi.202000089
  160. M. Cui, M. Zheng, C. Wiraja, S.W.T. Chew, A. Mishra et al., Ocular delivery of predatory bacteria with cryomicroneedles against eye infection. Adv. Sci. 8, e2102327 (2021). https://doi.org/10.1002/advs.202102327
  161. G. Roy, P. Garg, V.V.K. Venuganti, Microneedle scleral patch for minimally invasive delivery of triamcinolone to the posterior segment of eye. Int. J. Pharm. 612, 121305 (2022). https://doi.org/10.1016/j.ijpharm.2021.121305
  162. Y. Fang, L. Zhuo, H. Yuan, H. Zhao, L. Zhang, Construction of graphene quantum dot-based dissolving microneedle patches for the treatment of bacterial keratitis. Int. J. Pharm. 639, 122945 (2023). https://doi.org/10.1016/j.ijpharm.2023.122945
  163. X. Jiang, Y. Jin, Y. Zeng, P. Shi, W. Li, Self-implantable core–shell microneedle patch for long-acting treatment of keratitis via programmed drug release. Small (2024). https://doi.org/10.1002/smll.202310461
  164. T. Miyano, Y. Tobinaga, T. Kanno, Y. Matsuzaki, H. Takeda et al., Sugar micro needles as transdermic drug delivery system. Biomed. Microdevices 7, 185–188 (2005). https://doi.org/10.1007/s10544-005-3024-7
  165. Y. Wu, L.K. Vora, D. Mishra, M.F. Adrianto, S. Gade et al., Nanosuspension-loaded dissolving bilayer microneedles for hydrophobic drug delivery to the posterior segment of the eye. Biomater. Adv. 137, 212767 (2022). https://doi.org/10.1016/j.bioadv.2022.212767
  166. M.G. McGrath, S. Vucen, A. Vrdoljak, A. Kelly, C. O’Mahony et al., Production of dissolvable microneedles using an atomised spray process: effect of microneedle composition on skin penetration. Eur. J. Pharm. Biopharm. 86, 200–211 (2014). https://doi.org/10.1016/j.ejpb.2013.04.023
  167. B.-M. Lee, C. Lee, S.F. Lahiji, U.-W. Jung, G. Chung et al., Dissolving microneedles for rapid and painless local anesthesia. Pharmaceutics 12, 366 (2020). https://doi.org/10.3390/pharmaceutics12040366
  168. W. Zhu, W. Pewin, C. Wang, Y. Luo, G.X. Gonzalez et al., A boosting skin vaccination with dissolving microneedle patch encapsulating M2e vaccine broadens the protective efficacy of conventional influenza vaccines. J. Control. Release 261, 1–9 (2017). https://doi.org/10.1016/j.jconrel.2017.06.017
  169. N.W. Kim, S.-Y. Kim, J.E. Lee, Y. Yin, J.H. Lee et al., Enhanced cancer vaccination by in situ nanomicelle-generating dissolving microneedles. ACS Nano 12, 9702–9713 (2018). https://doi.org/10.1021/acsnano.8b04146
  170. L.E. Moore, S. Vucen, A.C. Moore, Trends in drug-and vaccine-based dissolvable microneedle materials and methods of fabrication. Eur. J. Pharm. Biopharm. 173, 54–72 (2022). https://doi.org/10.1016/j.ejpb.2022.02.013
  171. C. Kuwentrai, J. Yu, L. Rong, B.Z. Zhang, Y.F. Hu et al., Intradermal delivery of receptor-binding domain of SARS-CoV-2 spike protein with dissolvable microneedles to induce humoral and cellular responses in mice. Bioeng. Transl. Med. 6, e10202 (2021). https://doi.org/10.1002/btm2.10202
  172. A. Donadei, H. Kraan, O. Ophorst, O. Flynn, C. O’Mahony et al., Skin delivery of trivalent sabin inactivated poliovirus vaccine using dissolvable microneedle patches induces neutralizing antibodies. J. Control. Release 311, 96–103 (2019). https://doi.org/10.1016/j.jconrel.2019.08.039
  173. M.-C. Chen, K.-Y. Lai, M.-H. Ling, C.-W. Lin, Enhancing immunogenicity of antigens through sustained intradermal delivery using chitosan microneedles with a patch-dissolvable design. Acta Biomater. 65, 66–75 (2018). https://doi.org/10.1016/j.actbio.2017.11.004
  174. E. Kim, G. Erdos, S. Huang, T.W. Kenniston, S.C. Balmert et al., Microneedle array delivered recombinant coronavirus vaccines: immunogenicity and rapid translational development. EBioMedicine 55, 102743 (2020). https://doi.org/10.1016/j.ebiom.2020.102743
  175. P.R. Yadav, M.N. Munni, L. Campbell, G. Mostofa, L. Dobson et al., Translation of polymeric microneedles for treatment of human diseases: recent trends, progress, and challenges. Pharmaceutics 13, 1132 (2021). https://doi.org/10.3390/pharmaceutics13081132
  176. R. Jamaledin, C. Di Natale, V. Onesto, Z.B. Taraghdari, E.N. Zare et al., Progress in microneedle-mediated protein delivery. J. Clin. Med. 9, 542 (2020). https://doi.org/10.3390/jcm9020542
  177. D. Jakka, A.V. Matadh, V.K. Shankar, H. Shivakumar, S.N. Murthy, Polymer coated polymeric (PCP) microneedles for controlled delivery of drugs (dermal and intravitreal). J. Pharm. Sci. 111, 2867–2878 (2022). https://doi.org/10.1016/j.xphs.2022.05.023
  178. H. Chang, M. Zheng, X. Yu, A. Than, R.Z. Seeni et al., A swellable microneedle patch to rapidly extract skin interstitial fluid for timely metabolic analysis. Adv. Mater. 29, 1702243 (2017). https://doi.org/10.1002/adma.201702243
  179. H.S. Gill, M.R. Prausnitz, Coated microneedles for transdermal delivery. J. Control. Release 117, 227–237 (2007). https://doi.org/10.1016/j.jconrel.2006.10.017
  180. W. Li, G. Hua, J. Cai, Y. Zhou, X. Zhou et al., Multi-stimulus responsive multilayer coating for treatment of device-associated infections. J. Funct. Biomater. 13, 24 (2022). https://doi.org/10.3390/jfb13010024
  181. Y. Chen, B.Z. Chen, Q.L. Wang, X. Jin, X.D. Guo, Fabrication of coated polymer microneedles for transdermal drug delivery. J. Control. Release 265, 14–21 (2017). https://doi.org/10.1016/j.jconrel.2017.03.383
  182. S. Li, W. Li, M. Prausnitz, Individually coated microneedles for co-delivery of multiple compounds with different properties. Drug Deliv. Transl. Res. 8, 1043–1052 (2018). https://doi.org/10.1007/s13346-018-0549-x
  183. R.H. Chong, E. Gonzalez-Gonzalez, M.F. Lara, T.J. Speaker, C.H. Contag et al., Gene silencing following siRNA delivery to skin via coated steel microneedles: in vitro and in vivo proof-of-concept. J. Control. Release 166, 211–219 (2013). https://doi.org/10.1016/j.jconrel.2012.12.030
  184. Y. Shin, J. Kim, J.H. Seok, H. Park, H.-R. Cha et al., Development of the H3N2 influenza microneedle vaccine for cross-protection against antigenic variants. Sci. Rep. 12, 12189 (2022). https://doi.org/10.1038/s41598-022-16365-2
  185. J.G. Turner, L.R. White, P. Estrela, H.S. Leese, Hydrogel-forming microneedles: current advancements and future trends. Macromol. Biosci. 21, 2000307 (2021). https://doi.org/10.1002/mabi.202000307
  186. M. Kim, B. Jung, J.-H. Park, Hydrogel swelling as a trigger to release biodegradable polymer microneedles in skin. Biomaterials 33, 668–678 (2012). https://doi.org/10.1016/j.biomaterials.2011.09.074
  187. H. Dawud, N. Edelstein-Pardo, K. Mulamukkil, R.J. Amir, A. Abu Ammar, Hydrogel microneedles with programmed mesophase transitions for controlled drug delivery. ACS Appl. Bio Mater. 7, 1682–1693 (2024). https://doi.org/10.1021/acsabm.3c01133
  188. Z. Li, P. Zhao, Z. Ling, Y. Zheng, F. Qu et al., An ultraswelling microneedle device for facile and efficient drug loading and transdermal delivery. Adv. Healthc. Mater. 13, 2302406 (2024). https://doi.org/10.1002/adhm.202302406
  189. R.F. Donnelly, M.T. McCrudden, A. Zaid Alkilani, E. Larrañeta, E. McAlister et al., Hydrogel-forming microneedles prepared from “super swelling” polymers combined with lyophilised wafers for transdermal drug delivery. PLoS ONE 9, e111547 (2014). https://doi.org/10.1371/journal.pone.0111547
  190. J. Zhu, X. Zhou, H.J. Kim, M. Qu, X. Jiang et al., Gelatin methacryloyl microneedle patches for minimally invasive extraction of skin interstitial fluid. Small 16, 1905910 (2020). https://doi.org/10.1002/smll.201905910
  191. X. Hong, Z. Wu, L. Chen, F. Wu, L. Wei et al., Hydrogel microneedle arrays for transdermal drug delivery. Nano-Micro Lett. 6, 191–199 (2014). https://doi.org/10.1007/BF03353783
  192. E. Caffarel-Salvador, A.J. Brady, E. Eltayib, T. Meng, A. Alonso-Vicente et al., Hydrogel-forming microneedle arrays allow detection of drugs and glucose in vivo: potential for use in diagnosis and therapeutic drug monitoring. PLoS ONE 10, e0145644 (2015). https://doi.org/10.1371/journal.pone.0145644
  193. M.T. Hoang, K.B. Ita, D.A. Bair, Solid microneedles for transdermal delivery of amantadine hydrochloride and pramipexole dihydrochloride. Pharmaceutics 7, 379–396 (2015). https://doi.org/10.3390/pharmaceutics7040379
  194. F.K. Aldawood, A. Andar, S. Desai, A comprehensive review of microneedles: types, materials, processes, characterizations and applications. Polymers 13, 2815 (2021). https://doi.org/10.3390/polym13162815
  195. C.E. Umeyor, V. Shelke, A. Pol, P. Kolekar, S. Jadhav et al., Biomimetic microneedles: Exploring the recent advances on a microfabricated system for precision delivery of drugs, peptides, and proteins. Future J. Pharm. Sci. 9, 103 (2023). https://doi.org/10.1186/s43094-023-00553-6
  196. S. Pradeep Narayanan, S. Raghavan, Solid silicon microneedles for drug delivery applications. Int. J. Adv. Manuf. Technol. 93, 407–422 (2017). https://doi.org/10.1007/s00170-016-9698-6
  197. W. Li, Y.M. Zhang, J. Chen, Design, fabrication and characterization of in-plane titanium microneedles for transdermal drug delivery. Key Eng. Mater. 483, 532–536 (2011). https://doi.org/10.4028/www.scientific.net/KEM.483.532
  198. Z. Ding, F.J. Verbaan, M. Bivas-Benita, L. Bungener, A. Huckriede et al., Microneedle arrays for the transcutaneous immunization of diphtheria and influenza in BALB/c mice. J. Control. Release 136, 71–78 (2009). https://doi.org/10.1016/j.jconrel.2009.01.025
  199. Q.Y. Li, J.N. Zhang, B.Z. Chen, Q.L. Wang, X.D. Guo, A solid polymer microneedle patch pretreatment enhances the permeation of drug molecules into the skin. RSC Adv. 7, 15408–15415 (2017). https://doi.org/10.1039/C6RA26759A
  200. W. Shu, H. Heimark, N. Bertollo, D.J. Tobin, E.D. O’Cearbhaill et al., Insights into the mechanics of solid conical microneedle array insertion into skin using the finite element method. Acta Biomater. 135, 403–413 (2021). https://doi.org/10.1016/j.actbio.2021.08.045
  201. N.N. Ahmad, N.N.N. Ghazali, Y.H. Wong, Mechanical and fluidic analysis of hollow side-open and outer-grooved design of microneedles. Mater. Today Commun. 29, 102940 (2021). https://doi.org/10.1016/j.mtcomm.2021.102940
  202. L. Huang, H. Fang, T. Zhang, B. Hu, S. Liu et al., Drug-loaded balloon with built-in nir controlled tip-separable microneedles for long-effective arteriosclerosis treatment. Bioact. Mater. 23, 526–538 (2023). https://doi.org/10.1016/j.bioactmat.2022.11.015
  203. E. Larrañeta, R.E. Lutton, A.D. Woolfson, R.F. Donnelly, Microneedle arrays as transdermal and intradermal drug delivery systems: materials science, manufacture and commercial development. Mater. Sci. Eng. R. Rep. 104, 1–32 (2016). https://doi.org/10.1016/J.MSER.2016.03.001
  204. S.R. Patel, A.S. Lin, H.F. Edelhauser, M.R. Prausnitz, Suprachoroidal drug delivery to the back of the eye using hollow microneedles. Pharm. Res. 28, 166–176 (2011). https://doi.org/10.1007/s11095-010-0271-y
  205. K. van der Maaden, J. Heuts, M. Camps, M. Pontier, A.T. van Scheltinga et al., Hollow microneedle-mediated micro-injections of a liposomal HPV E743–63 synthetic long peptide vaccine for efficient induction of cytotoxic and t-helper responses. J. Control. Release 269, 347–354 (2018). https://doi.org/10.1016/j.jconrel.2017.11.035
  206. M. Fratus, M.A. Alam, Theory of nanostructured sensors integrated in/on microneedles for diagnostics and therapy. Biosens. Bioelectron. 255, 116238 (2024). https://doi.org/10.1016/j.bios.2024.116238
  207. X. Zhang, G. Chen, L. Cai, Y. Wang, L. Sun et al., Bioinspired pagoda-like microneedle patches with strong fixation and hemostasis capabilities. Chem. Eng. J. 414, 128905 (2021). https://doi.org/10.1016/j.cej.2021.128905
  208. W.-G. Bae, H. Ko, J.-Y. So, H. Yi, C.-H. Lee et al., Snake fang–inspired stamping patch for transdermal delivery of liquid formulations. Sci. Transl. Med. 11, eaaw3329 (2019). https://doi.org/10.1126/scitranslmed.aaw3329
  209. W.K. Cho, J.A. Ankrum, D. Guo, S.A. Chester, S.Y. Yang et al., Microstructured barbs on the North American porcupine quill enable easy tissue penetration and difficult removal. Proc. Natl. Acad. Sci. U.S.A. 109, 21289–21294 (2012). https://doi.org/10.1073/pnas.1216441109
  210. X. Zhang, G. Chen, L. Sun, F. Ye, X. Shen et al., Claw-inspired microneedle patches with liquid metal encapsulation for accelerating incisional wound healing. Chem. Eng. J. 406, 126741 (2021). https://doi.org/10.1016/j.cej.2020.126741
  211. Y. Deng, C. Yang, Y. Zhu, W. Liu, H. Li et al., Lamprey-teeth-inspired oriented antibacterial sericin microneedles for infected wound healing improvement. Nano Lett. 22, 2702–2711 (2022). https://doi.org/10.1021/acs.nanolett.1c04573
  212. M. Guo, Y. Wang, B. Gao, B. He, Shark tooth-inspired microneedle dressing for intelligent wound management. ACS Nano 15, 15316–15327 (2021). https://doi.org/10.1021/acsnano.1c06279
  213. Z. Zhu, J. Wang, X. Pei, J. Chen, X. Wei et al., Blue-ringed octopus-inspired microneedle patch for robust tissue surface adhesion and active injection drug delivery. Sci. Adv. 9, eadh2213 (2023). https://doi.org/10.1126/sciadv.adh2213
  214. K. Moussi, A.A. Haneef, R.A. Alsiary, E.M. Diallo, M.A. Boone et al., A microneedles balloon catheter for endovascular drug delivery. Adv. Mater. Technol. 6, 2100037 (2021). https://doi.org/10.1002/admt.202100037
  215. K. Lee, J. Lee, S.G. Lee, S. Park, J.-J. Lee et al., Microneedle drug eluting balloon for enhanced drug delivery to vascular tissue. J. Control. Release 321, 174–183 (2020). https://doi.org/10.1016/j.jconrel.2020.02.012
  216. J. Luo, J.-K. Wang, B.-L. Song, Lowering low-density lipoprotein cholesterol: from mechanisms to therapies. Life Metab. 1, 25–38 (2022). https://doi.org/10.1093/lifemeta/loac004
  217. X. Zhang, Y. Cheng, R. Liu, Y. Zhao, Globefish-inspired balloon catheter with intelligent microneedle coating for endovascular drug delivery. Adv. Sci. 9, 2204497 (2022). https://doi.org/10.1002/advs.202204497
  218. J.M. Loh, Y.J.L. Lim, J.T. Tay, H.M. Cheng, H.L. Tey et al., Design and fabrication of customizable microneedles enabled by 3D printing for biomedical applications. Bioact. Mater. 32, 222–241 (2024). https://doi.org/10.1016/j.bioactmat.2023.09.022
  219. C. Yeung, S. Chen, B. King, H. Lin, K. King et al., A 3D-printed microfluidic-enabled hollow microneedle architecture for transdermal drug delivery. Biomicrofluidics 13, 064125 (2019). https://doi.org/10.1063/1.5127778
  220. P.R. Miller, S.D. Gittard, T.L. Edwards, D.M. Lopez, X. Xiao et al., Integrated carbon fiber electrodes within hollow polymer microneedles for transdermal electrochemical sensing. Biomicrofluidics 5, 013415 (2011). https://doi.org/10.1063/1.3569945
  221. L. Zheng, D. Zhu, Y. Xiao, X. Zheng, P. Chen, Microneedle coupled epidermal sensor for multiplexed electrochemical detection of kidney disease biomarkers. Biosens. Bioelectron. 237, 115506 (2023). https://doi.org/10.1016/j.bios.2023.115506
  222. L. Lin, Y. Wang, M. Cai, X. Jiang, Y. Hu et al., Multimicrochannel microneedle microporation platform for enhanced intracellular drug delivery. Adv. Funct. Mater. 32, 2109187 (2022). https://doi.org/10.1002/adfm.202270122
  223. C. Farias, R. Lyman, C. Hemingway, H. Chau, A. Mahacek et al., Three-dimensional (3D) printed microneedles for microencapsulated cell extrusion. Bioengineering 5, 59 (2018). https://doi.org/10.3390/bioengineering5030059
  224. S. Wang, M. Zhao, Y. Yan, P. Li, W. Huang, Flexible monitoring, diagnosis, and therapy by microneedles with versatile materials and devices toward multifunction scope. Research 6, 0128 (2023). https://doi.org/10.34133/research.0128
  225. M. Tavafoghi, F. Nasrollahi, S. Karamikamkar, M. Mahmoodi, S. Nadine et al., Advances and challenges in developing smart, multifunctional microneedles for biomedical applications. Biotechnol. Bioeng. 119, 2715–2730 (2022). https://doi.org/10.1002/bit.28186
  226. Y. Zhou, B. Niu, Y. Zhao, J. Fu, T. Wen et al., Multifunctional nanoreactors-integrated microneedles for cascade reaction-enhanced cancer therapy. J. Control. Release 339, 335–349 (2021). https://doi.org/10.1016/j.jconrel.2021.09.041
  227. A. Tucak, M. Sirbubalo, L. Hindija, O. Rahić, J. Hadžiabdić et al., Microneedles: characteristics, materials, production methods and commercial development. Micromachines 11, 961 (2020). https://doi.org/10.3390/mi11110961
  228. Y. Su, V.L. Mainardi, H. Wang, A. McCarthy, Y.S. Zhang et al., Dissolvable microneedles coupled with nanofiber dressings eradicate biofilms via effectively delivering a database-designed antimicrobial peptide. ACS Nano 14, 11775–11786 (2020). https://doi.org/10.1021/acsnano.0c04527
  229. H. Yang, S. Kim, I. Huh, S. Kim, S.F. Lahiji et al., Rapid implantation of dissolving microneedles on an electrospun pillar array. Biomaterials 64, 70–77 (2015). https://doi.org/10.1016/j.biomaterials.2015.06.027
  230. J.D. Kim, M. Kim, H. Yang, K. Lee, H. Jung, Droplet-born air blowing: novel dissolving microneedle fabrication. J. Control. Release 170, 430–436 (2013). https://doi.org/10.1016/j.jconrel.2013.05.026
  231. K. Lee, C.Y. Lee, H. Jung, Dissolving microneedles for transdermal drug administration prepared by stepwise controlled drawing of maltose. Biomaterials 32, 3134–3140 (2011). https://doi.org/10.1016/j.biomaterials.2011.01.014
  232. S. Fakhraei Lahiji, Y. Kim, G. Kang, S. Kim, S. Lee et al., Tissue interlocking dissolving microneedles for accurate and efficient transdermal delivery of biomolecules. Sci. Rep. 9, 7886 (2019). https://doi.org/10.1038/s41598-019-44418-6
  233. Q.L. Wang, D.D. Zhu, Y. Chen, X.D. Guo, A fabrication method of microneedle molds with controlled microstructures. Mater. Sci. Eng. C 65, 135–142 (2016). https://doi.org/10.1016/j.msec.2016.03.097
  234. P. Singh, A. Carrier, Y. Chen, S. Lin, J. Wang et al., Polymeric microneedles for controlled transdermal drug delivery. J. Control. Release 315, 97–113 (2019). https://doi.org/10.1016/j.jconrel.2019.10.022
  235. K. Badnikar, S.N. Jayadevi, S. Pahal, S. Sripada, M.M. Nayak et al., Generic molding platform for simple, low-cost fabrication of polymeric microneedles. Macromol. Mater. Eng. 305, 2000072 (2020). https://doi.org/10.1002/mame.202070011
  236. M.J. Kim, S.C. Park, S.-O. Choi, Dual-nozzle spray deposition process for improving the stability of proteins in polymer microneedles. RSC Adv. 7, 55350–55359 (2017). https://doi.org/10.1039/C7RA10928H
  237. B. Bediz, E. Korkmaz, R. Khilwani, C. Donahue, G. Erdos et al., Dissolvable microneedle arrays for intradermal delivery of biologics: fabrication and application. Pharm. Res. 31, 117–135 (2014). https://doi.org/10.1007/s11095-013-1137-x
  238. J.W. Lee, J.-H. Park, M.R. Prausnitz, Dissolving microneedles for transdermal drug delivery. Biomaterials 29, 2113–2124 (2008). https://doi.org/10.1016/j.biomaterials.2007.12.048
  239. S.P. Sullivan, N. Murthy, M.R. Prausnitz, Minimally invasive protein delivery with rapidly dissolving polymer microneedles. Adv. Mater. 20, 933–938 (2008). https://doi.org/10.1002/adma.200701205
  240. S.C. Park, M.J. Kim, S.-K. Baek, J.-H. Park, S.-O. Choi, Spray-formed layered polymer microneedles for controlled biphasic drug delivery. Polymers 11, 369 (2019). https://doi.org/10.3390/polym11020369
  241. K. Valachová, M.A. El Meligy, L. Šoltés, Hyaluronic acid and chitosan-based electrospun wound dressings: problems and solutions. Int. J. Biol. Macromol. 206, 74–91 (2022). https://doi.org/10.1016/j.ijbiomac.2022.02.117
  242. R. Augustine, S.R.U. Rehman, R. Ahmed, A.A. Zahid, M. Sharifi et al., Electrospun chitosan membranes containing bioactive and therapeutic agents for enhanced wound healing. Int. J. Biol. Macromol. 156, 153–170 (2020). https://doi.org/10.1016/j.ijbiomac.2020.03.207
  243. B.P. Antunes, A.F. Moreira, V.M. Gaspar, I.J. Correia, Chitosan/arginine–chitosan polymer blends for assembly of nanofibrous membranes for wound regeneration. Carbohyd. Polym. 130, 104–112 (2015). https://doi.org/10.1016/j.carbpol.2015.04.072
  244. Y. Wang, P. Guan, R. Tan, Z. Shi, Q. Li et al., Fiber-reinforced silk microneedle patches for improved tissue adhesion in treating diabetic wound infections. Adv. Fiber Mater. (2024). https://doi.org/10.1007/s42765-024-00439-z
  245. L. Fu, Q. Feng, Y. Chen, J. Fu, X. Zhou et al., Nanofibers for the immunoregulation in biomedical applications. Adv. Fiber Mater. 4, 1334–1356 (2022). https://doi.org/10.1007/s42765-022-00191-2
  246. H. He, M. Wu, J. Zhu, Y. Yang, R. Ge et al., Engineered spindles of little molecules around electrospun nanofibers for biphasic drug release. Adv. Fiber Mater. 4, 305–317 (2022). https://doi.org/10.1007/s42765-021-00112-9
  247. Y. Long, L. Li, T. Xu, X. Wu, Y. Gao et al., Hedgehog artificial macrophage with atomic-catalytic centers to combat drug-resistant bacteria. Nat. Commun. 12, 6143 (2021). https://doi.org/10.1038/s41467-021-26456-9
  248. S. Xiao, L. Xie, Y. Gao, M. Wang, W. Geng et al., Artificial phages with biocatalytic spikes for synergistically eradicating antibiotic-resistant biofilms. Adv. Mater. (2024). https://doi.org/10.1002/adma.202404411
  249. H.K. Azar, M.H. Monfared, A.A. Seraji, S. Nazarnezhad, E. Nasiri et al., Integration of polysaccharide electrospun nanofibers with microneedle arrays promotes wound regeneration: a review. Int. J. Biol. Macromol. 258, 128482 (2023). https://doi.org/10.1016/j.ijbiomac.2023.128482
  250. S. Bhatnagar, P.R. Gadeela, P. Thathireddy, V.V.K. Venuganti, Microneedle-based drug delivery: materials of construction. J. Chem. Sci. 131, 1–28 (2019). https://doi.org/10.1007/s12039-019-1666-x
  251. M. Ali, S. Namjoshi, H.A. Benson, Y. Mohammed, T. Kumeria, Dissolvable polymer microneedles for drug delivery and diagnostics. J. Control. Release 347, 561–589 (2022). https://doi.org/10.1016/j.jconrel.2022.04.043
  252. S.N. Economidou, C.P.P. Pere, A. Reid, M.J. Uddin, J.F. Windmill et al., 3D printed microneedle patches using stereolithography (SLA) for intradermal insulin delivery. Mater. Sci. Eng. C 102, 743–755 (2019). https://doi.org/10.1016/j.msec.2019.04.063
  253. K. Lee, H.C. Lee, D.S. Lee, H. Jung, Drawing lithography: three-dimensional fabrication of an ultrahigh-aspect-ratio microneedle. Adv. Mater. 22, 483–486 (2010). https://doi.org/10.1002/adma.200902418
  254. R. Vecchione, S. Coppola, E. Esposito, C. Casale, V. Vespini et al., Electro-drawn drug-loaded biodegradable polymer microneedles as a viable route to hypodermic injection. Adv. Funct. Mater. 24, 3515–3523 (2014). https://doi.org/10.1002/adfm.201303679
  255. Z. Chen, L. Ren, J. Li, L. Yao, Y. Chen et al., Rapid fabrication of microneedles using magnetorheological drawing lithography. Acta Biomater. 65, 283–291 (2018). https://doi.org/10.1016/j.actbio.2017.10.030
  256. F. Ruggiero, R. Vecchione, S. Bhowmick, G. Coppola, S. Coppola et al., Electro-drawn polymer microneedle arrays with controlled shape and dimension. Sens. Actuators B Chem. 255, 1553–1560 (2018). https://doi.org/10.1016/J.SNB.2017.08.165
  257. H. Yang, S. Kim, G. Kang, S.F. Lahiji, M. Jang et al., Centrifugal lithography: self-shaping of polymer microstructures encapsulating biopharmaceutics by centrifuging polymer drops. Adv. Healthc. Mater. 6, 1700326 (2017). https://doi.org/10.1002/adhm.201700326
  258. I. Huh, S. Kim, H. Yang, M. Jang, G. Kang et al., Effects of two droplet-based dissolving microneedle manufacturing methods on the activity of encapsulated epidermal growth factor and ascorbic acid. Eur. J. Pharm. Sci. 114, 285–292 (2018). https://doi.org/10.1016/j.ejps.2017.12.025
  259. C. Lee, H. Kim, S. Kim, S.F. Lahiji, N.Y. Ha et al., Comparative study of two droplet-based dissolving microneedle fabrication methods for skin vaccination. Adv. Healthc. Mater. 7, 1701381 (2018). https://doi.org/10.1002/adhm.201701381
  260. M. Olowe, S.K. Parupelli, S. Desai, A review of 3D-printing of microneedles. Pharmaceutics 14, 2693 (2022). https://doi.org/10.3390/pharmaceutics14122693
  261. M.A. Luzuriaga, D.R. Berry, J.C. Reagan, R.A. Smaldone, J.J. Gassensmith, Biodegradable 3D printed polymer microneedles for transdermal drug delivery. Lab Chip 18, 1223–1230 (2018). https://doi.org/10.1039/c8lc00098k
  262. L. Wu, J. Park, Y. Kamaki, B. Kim, Optimization of the fused deposition modeling-based fabrication process for polylactic acid microneedles. Microsyst. Nanoeng. 7, 58 (2021). https://doi.org/10.1038/s41378-021-00284-9
  263. U. Detamornrat, E. McAlister, A.R. Hutton, E. Larrañeta, R.F. Donnelly, The role of 3D printing technology in microengineering of microneedles. Small 18, 2106392 (2022). https://doi.org/10.1002/smll.202106392
  264. R. Wichniarek, W. Kuczko, D. Tomczak, A. Nowicka, M. Wojtyłko et al., Geometrical accuracy and strength of micro-needles made of polylactide by fused filament fabrication method. Adv. Colloid Interface Sci. 17, 116–126 (2023). https://doi.org/10.12913/22998624/174079
  265. C.P.P. Pere, S.N. Economidou, G. Lall, C. Ziraud, J.S. Boateng et al., 3D printed microneedles for insulin skin delivery. Int. J. Pharm. 544, 425–432 (2018). https://doi.org/10.1016/j.ijpharm.2018.03.031
  266. K.J. Krieger, N. Bertollo, M. Dangol, J.T. Sheridan, M.M. Lowery et al., Simple and customizable method for fabrication of high-aspect ratio microneedle molds using low-cost 3D printing. Microsyst. Nanoeng. 5, 42 (2019). https://doi.org/10.1038/s41378-019-0088-8
  267. S. Choo, S. Jin, J. Jung, Fabricating high-resolution and high-dimensional microneedle mold through the resolution improvement of stereolithography 3D printing. Pharmaceutics 14, 766 (2022). https://doi.org/10.3390/pharmaceutics14040766
  268. A. Bertino, L. Mazzeo, G. Caputo, S. Sau, A. Giaconia et al., Continuous multiphase bunsen reactor of iodine–sulfur thermochemical water splitting cycles for hydrogen production: experimental, modelling and design insights. Chem. Eng. J. 481, 148415 (2024). https://doi.org/10.1016/j.cej.2023.148415
  269. D. Shin, J. Hyun, Silk fibroin microneedles fabricated by digital light processing 3D printing. J. Ind. Eng. Chem. 95, 126–133 (2021). https://doi.org/10.1016/j.jiec.2020.12.011
  270. A. Ovsianikov, B. Chichkov, P. Mente, N. Monteiro-Riviere, A. Doraiswamy et al., Two photon polymerization of polymer–ceramic hybrid materials for transdermal drug delivery. Int. J. Appl. Ceram. Technol. 4, 22–29 (2007). https://doi.org/10.1111/j.1744-7402.2007.02115.x
  271. D. Han, R.S. Morde, S. Mariani, A.A. La Mattina, E. Vignali et al., 4D printing of a bioinspired microneedle array with backward-facing barbs for enhanced tissue adhesion. Adv. Funct. Mater. 30, 1909197 (2020). https://doi.org/10.1002/adfm.201909197
  272. R. Parhi, Recent advances in 3D printed microneedles and their skin delivery application in the treatment of various diseases. J. Drug Deliv. Sci. Technol. 84, 104395 (2023). https://doi.org/10.1016/j.jddst.2023.104395
  273. H. Ako, J. O’Mahony, H. Hughes, P. McLoughlin, N.J. O’Reilly, A novel approach to the manufacture of dissolving microneedles arrays using aerosol jet printing. Appl. Mater. Today 35, 101958 (2023). https://doi.org/10.1016/j.apmt.2023.101958
  274. Y. Li, K. Chen, Y. Pang, J. Zhang, M. Wu et al., Multifunctional microneedle patches via direct ink drawing of nanocomposite inks for personalized transdermal drug delivery. ACS Nano 17, 19925–19937 (2023). https://doi.org/10.1021/acsnano.3c04758
  275. R. Li, L. Zhang, X. Jiang, L. Li, S. Wu et al., 3D-printed microneedle arrays for drug delivery. J. Control. Release 350, 933–948 (2022). https://doi.org/10.1016/j.jconrel.2022.08.022
  276. J.R. Tumbleston, D. Shirvanyants, N. Ermoshkin, R. Janusziewicz, A.R. Johnson et al., Continuous liquid interface production of 3D objects. Science 347, 1349–1352 (2015). https://doi.org/10.1126/science.aaa2397
  277. S.S. Al-Nimry, R.M. Daghmash, Three dimensional printing and its applications focusing on microneedles for drug delivery. Pharmaceutics 15, 1597 (2023). https://doi.org/10.3390/pharmaceutics15061597
  278. S.N. Economidou, C.P. Pissinato Pere, M. Okereke, D. Douroumis, Optimisation of design and manufacturing parameters of 3D printed solid microneedles for improved strength, sharpness, and drug delivery. Micromachines 12, 117 (2021). https://doi.org/10.3390/mi12020117
  279. S. Feng, J. Delannoy, A. Malod, H. Zheng, D. Quéré et al., Tip-induced flipping of droplets on Janus pillars: from local reconfiguration to global transport. Sci. Adv. 6, eabb4540 (2020). https://doi.org/10.1126/sciadv.abb4540
  280. Y. Zambito, G. Di Colo, Polysaccharides as excipients for ocular topical formulations, Biomaterials Applications for Nanomedicine, (2011), pp. 253–280. https://doi.org/10.5772/24430
  281. R.V. Moiseev, P.W. Morrison, F. Steele, V.V. Khutoryanskiy, Penetration enhancers in ocular drug delivery. Pharmaceutics 11, 321 (2019). https://doi.org/10.3390/pharmaceutics11070321
  282. R.N. Van G
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