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Vol. 11 (2019)

Single NIR Laser-Activated Multifunctional Nanoparticles for Cascaded Photothermal and Oxygen-Independent Photodynamic Therapy

https://doi.org/10.1007/s40820-019-0298-5
Xiaomin Li
Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, People’s Republic of China
Yang Liu
Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, People’s Republic of China
Fei Fu
Department of Radiology, Tianjin Hospital, Tianjin 300210, People’s Republic of China
Mingbo Cheng
Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, People’s Republic of China
Yutong Liu
Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, People’s Republic of China
Licheng Yu
Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, People’s Republic of China
Wei Wang
Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, People’s Republic of China
Yeda Wan
Department of Radiology, Tianjin Hospital, Tianjin 300210, People’s Republic of China
Zhi Yuan
Key Laboratory of Functional Polymer Materials of Ministry of Education, Institute of Polymer Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, People’s Republic of China

Corresponding Author: Zhi Yuan

zhiy@nankai.edu.cn

Nano-Micro Letters, Vol. 11 (2019), Article Number: 68

Abstract

Inconvenient dual-laser irradiation and tumor hypoxic environment as well as limited judgment of treating region have impeded the development of combined photothermal and photodynamic therapies (PTT and PDT). Herein, Bi2Se3@AIPH nanoparticles (NPs) are facilely developed to overcome these problems. Through a one-step method, free radical generator (AIPH) and phase transition material (lauric acid, LA, 44–46 °C) are encapsulated in hollow bismuth selenide nanoparticles (Bi2Se3 NPs). Under a single 808-nm laser irradiation at the tumor area, hyperthermia produced by Bi2Se3 not only directly leads to cell death, but also promotes AIPH release by melting LA and triggers free radical generation, which could further eradicate tumor cells in hypoxic environments. Moreover, Bi2Se3 with high X-ray attenuation coefficient endows the NPs with high computed tomography (CT) imaging capability, which is important for treating area determination. The results exhibit that Bi2Se3@AIPH NPs possesses 31.2% photothermal conversion efficiency for enhanced PTT, ideal free radical generation for oxygen-independent PDT, and 37.77 HU mL mg−1 X-ray attenuation coefficient for CT imaging with high quality. Most importantly, the tumor growth inhibition rate by synergistic PTT, PDT, and following immunotherapy is 99.6%, and even one tumor disappears completely, which demonstrates excellent cascaded synergistic effect of Bi2Se3@AIPH NPs for the tumor therapy.


Highlights:


1 Bi2Se3@AIPH nanoparticles (NPs) can realize photothermal and photodynamic therapies in a cascading manner when exposed to “one” single NIR laser.
2 Hyperthermia produced by Bi2Se3 NPs under NIR laser irradiation cannot only be used for photothermal therapy, but also the “switch” for controlled release of AIPH and excitation of free radical at the tumor site.
3 Free radical produced by thermal-responsive decomposition of AIPH is oxygen-independent, which treats hypoxic tumor well and further enhances immune response.

Keywords

Bi2Se3 Free radical Oxygen-independent Photothermal Photodynamic
Li, Xiaomin, Yang Liu, Fei Fu, Mingbo Cheng, Yutong Liu, Licheng Yu, Wei Wang, Yeda Wan, and Zhi Yuan. 2019. “Single NIR Laser-Activated Multifunctional Nanoparticles for Cascaded Photothermal and Oxygen-Independent Photodynamic Therapy”. Nano-Micro Letters 11 (August):68. https://doi.org/10.1007/s40820-019-0298-5.
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