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Vol. 14 (2022)

A Sub-Nanostructural Transformable Nanozyme for Tumor Photocatalytic Therapy

https://doi.org/10.1007/s40820-022-00848-y
Xi Hu
Institute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People’s Republic of China
Nan Wang
Institute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People’s Republic of China
Xia Guo
Institute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People’s Republic of China
Zeyu Liang
Institute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People’s Republic of China
Heng Sun
Institute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People’s Republic of China
Hongwei Liao
Institute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People’s Republic of China
Fan Xia
Institute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People’s Republic of China
Yunan Guan
Institute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People’s Republic of China
Jiyoung Lee
Institute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People’s Republic of China
Daishun Ling
Institute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People’s Republic of China
Fangyuan Li
Institute of Pharmaceutics, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People’s Republic of China

Corresponding Author: Fangyuan Li

lfy@zju.edu.cn

Nano-Micro Letters, Vol. 14 (2022), Article Number: 101

Abstract

The structural change-mediated catalytic activity regulation plays a significant role in the biological functions of natural enzymes. However, there is virtually no artificial nanozyme reported that can achieve natural enzyme-like stringent spatiotemporal structure-based catalytic activity regulation. Here, we report a sub-nanostructural transformable gold@ceria (STGC-PEG) nanozyme that performs tunable catalytic activities via near-infrared (NIR) light-mediated sub-nanostructural transformation. The gold core in STGC-PEG can generate energetic hot electrons upon NIR irradiation, wherein an internal sub-nanostructural transformation is initiated by the conversion between CeO2 and electron-rich state of CeO2−x, and active oxygen vacancies generation via the hot-electron injection. Interestingly, the sub-nanostructural transformation of STGC-PEG enhances peroxidase-like activity and unprecedentedly activates plasmon-promoted oxidase-like activity, allowing highly efficient low-power NIR light (50 mW cm−2)-activated photocatalytic therapy of tumors. Our atomic-level design and fabrication provide a platform to precisely regulate the catalytic activities of nanozymes via a light-mediated sub-nanostructural transformation, approaching natural enzyme-like activity control in complex living systems.


Highlights:


1 An internal sub-nanostructural transformation of sub-nanostructural transformable gold@ceria (STGC-PEG) is initiated by the conversion between CeO2 and electron-rich state of CeO2−x, and active oxygen vacancies generation via the hot-electron injection from gold to ceria.
2 The sub-nanostructural transformation of STGC-PEG enhances the peroxidase-like activity and activates the plasmon-promoted oxidase-like activity, resulting in an augmented reactive oxygen species output.
3 STGC-PEG successfully achieves excellent low power (50 mW cm−2) near-infrared light-activated photocatalytic ablation of tumors in vivo.

Keywords

Nanozymes Sub-nanostructural transformation Catalytic activity Reactive oxygen species Photocatalytic therapy
Hu, Xi, Nan Wang, Xia Guo, Zeyu Liang, Heng Sun, Hongwei Liao, Fan Xia, Yunan Guan, Jiyoung Lee, Daishun Ling, and Fangyuan Li. 2022. “A Sub-Nanostructural Transformable Nanozyme for Tumor Photocatalytic Therapy”. Nano-Micro Letters 14 (April):101. https://doi.org/10.1007/s40820-022-00848-y.
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