Issue

Vol. 13 (2021)

Nanoengineered Shear-Thinning Hydrogel Barrier for Preventing Postoperative Abdominal Adhesions

https://doi.org/10.1007/s40820-021-00712-5
Guillermo U. Ruiz‑Esparza
Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
Xichi Wang
Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
Xingcai Zhang
School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
Sofia Jimenez‑Vazquez
Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
Liliana Diaz‑Gomez
Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
Anne‑Marie Lavoie
Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
Samson Afewerki
Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
Andres A. Fuentes‑Baldemar
Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
Roberto Parra‑Saldivar
Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
Nan Jiang
Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
Nasim Annabi
Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA
Bahram Saleh
Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA
Ali K. Yetisen
Department of Chemical Engineering, Imperial College London, London SW7 2AZ, UK
Amir Sheikhi
Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
Thomas H. Jozefiak
Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
Su Ryon Shin
Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
Nianguo Dong
Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People’s Republic of China
Ali Khademhosseini
Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA

Corresponding Author: Ali Khademhosseini

khademh@terasaki.org

Nano-Micro Letters, Vol. 13 (2021), Article Number: 212

Abstract

More than 90% of surgical patients develop postoperative adhesions, and the incidence of hospital re-admissions can be as high as 20%. Current adhesion barriers present limited efficacy due to difficulties in application and incompatibility with minimally invasive interventions. To solve this clinical limitation, we developed an injectable and sprayable shear-thinning hydrogel barrier (STHB) composed of silicate nanoplatelets and poly(ethylene oxide). We optimized this technology to recover mechanical integrity after stress, enabling its delivery though injectable and sprayable methods. We also demonstrated limited cell adhesion and cytotoxicity to STHB compositions in vitro. The STHB was then tested in a rodent model of peritoneal injury to determine its efficacy preventing the formation of postoperative adhesions. After two weeks, the peritoneal adhesion index was used as a scoring method to determine the formation of postoperative adhesions, and STHB formulations presented superior efficacy compared to a commercially available adhesion barrier. Histological and immunohistochemical examination showed reduced adhesion formation and minimal immune infiltration in STHB formulations. Our technology demonstrated increased efficacy, ease of use in complex anatomies, and compatibility with different delivery methods, providing a robust universal platform to prevent postoperative adhesions in a wide range of surgical interventions.


Highlights:


1 A novel “nanoengineered hydrogel” barrier based on silicate nanoplatelets and poly(ethylene oxide) (PEO) was developed to prevent the formation of postoperative adhesions.
2 Compared to other hydrogel systems, the prepared biomaterial is injectable and sprayable which makes it compatible with minimally invasive interventions.

Keywords

Postoperative adhesions Shear-thinning hydrogel Silicate nanoplatelets Nanotechnology Nanomedicine
Ruiz‑Esparza, Guillermo U., Xichi Wang, Xingcai Zhang, Sofia Jimenez‑Vazquez, Liliana Diaz‑Gomez, Anne‑Marie Lavoie, Samson Afewerki, Andres A. Fuentes‑Baldemar, Roberto Parra‑Saldivar, Nan Jiang, Nasim Annabi, Bahram Saleh, Ali K. Yetisen, Amir Sheikhi, Thomas H. Jozefiak, Su Ryon Shin, Nianguo Dong, and Ali Khademhosseini. 2021. “Nanoengineered Shear-Thinning Hydrogel Barrier for Preventing Postoperative Abdominal Adhesions”. Nano-Micro Letters 13 (October):212. https://doi.org/10.1007/s40820-021-00712-5.
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