Issue

Vol. 16 (2024)

ROS Balance Autoregulating Core–Shell CeO2@ZIF-8/Au Nanoplatform for Wound Repair

https://doi.org/10.1007/s40820-024-01353-0
Xi Zhou
The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, People’s Republic of China
Quan Zhou
The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, People’s Republic of China
Zhaozhi He
The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, People’s Republic of China
Yi Xiao
John A Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
Yan Liu
John A Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
Zhuohang Huang
The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, People’s Republic of China
Yaoji Sun
Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, School of Electronic Science and Engineering, Xiamen University, Xiamen 361005, People’s Republic of China
Jiawei Wang
Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, School of Electronic Science and Engineering, Xiamen University, Xiamen 361005, People’s Republic of China
Zhengdong Zhao
Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People’s Republic of China
Xiaozhou Liu
Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People’s Republic of China
Bin Zhou
NO.1 Middle School Affiliated to Central China Normal University, Wuhan 430223, People’s Republic of China
Lei Ren
The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, Department of Biomaterials, College of Materials, Xiamen University, Xiamen 361005, People’s Republic of China
Yu Sun
Department of Otorhinolaryngology, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People’s Republic of China
Zhiwei Chen
Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, School of Electronic Science and Engineering, Xiamen University, Xiamen 361005, People’s Republic of China
Xingcai Zhang
John A Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA

Corresponding Author: Xingcai Zhang

zhangxingcai@wteao.com

Nano-Micro Letters, Vol. 16 (2024), Article Number: 156

Abstract

Reactive oxygen species (ROS) plays important roles in living organisms. While ROS is a double-edged sword, which can eliminate drug-resistant bacteria, but excessive levels can cause oxidative damage to cells. A core–shell nanozyme, CeO2@ZIF-8/Au, has been crafted, spontaneously activating both ROS generating and scavenging functions, achieving the multi-faceted functions of eliminating bacteria, reducing inflammation, and promoting wound healing. The Au Nanoparticles (NPs) on the shell exhibit high-efficiency peroxidase-like activity, producing ROS to kill bacteria. Meanwhile, the encapsulation of CeO2 core within ZIF-8 provides a seal for temporarily limiting the superoxide dismutase and catalase-like activities of CeO2 nanoparticles. Subsequently, as the ZIF-8 structure decomposes in the acidic microenvironment, the CeO2 core is gradually released, exerting its ROS scavenging activity to eliminate excess ROS produced by the Au NPs. These two functions automatically and continuously regulate the balance of ROS levels, ultimately achieving the function of killing bacteria, reducing inflammation, and promoting wound healing. Such innovative ROS spontaneous regulators hold immense potential for revolutionizing the field of antibacterial agents and therapies.


Highlights:
1 The innovation of this work mainly lies in the auto-regulation of reactive oxygen species (ROS) balance effective by combination of ROS antibacterial and ROS scavenging anti-inflammatory functions with a core–shell nanoplatform (CeO2@ZIF-8/Au), which can not only achieve high antibacterial efficiency, but also promote wound healing, and provide a new idea for the nano-catalytic system in the field of wound healing of bacterial infection.

Keywords

Metal–organic framework (MOF) Reactive oxygen species (ROS) Cerium dioxide Au nanoparticles Wound healing
Zhou, Xi, Quan Zhou, Zhaozhi He, Yi Xiao, Yan Liu, Zhuohang Huang, Yaoji Sun, Jiawei Wang, Zhengdong Zhao, Xiaozhou Liu, Bin Zhou, Lei Ren, Yu Sun, Zhiwei Chen, and Xingcai Zhang. 2024. “ROS Balance Autoregulating Core–Shell CeO2@ZIF-8/Au Nanoplatform for Wound Repair”. Nano-Micro Letters 16 (March):156. https://doi.org/10.1007/s40820-024-01353-0.
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