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Vol. 13 (2021)

MOFs-Based Nitric Oxide Therapy for Tendon Regeneration

https://doi.org/10.1007/s40820-020-00542-x
Jun Chen
Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 200040, People’s Republic of China
Dandan Sheng
Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 200040, People’s Republic of China
Ting Ying
College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, People’s Republic of China
Haojun Zhao
Department of Ultrasound, Jing’an District Center Hospital, Fudan University, Shanghai 200040, People’s Republic of China
Jian Zhang
Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 200040, People’s Republic of China
Yunxia Li
Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 200040, People’s Republic of China
He Xu
College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, People’s Republic of China
Shiyi Chen
Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 200040, People’s Republic of China

Corresponding Author: Shiyi Chen

cshiyi@163.com

Nano-Micro Letters, Vol. 13 (2021), Article Number: 23

Abstract

Tendon regeneration is still a great challenge due to its avascular structure and low self-renewal capability. The nitric oxide (NO) therapy emerges as a promising treatment for inducing the regeneration of injured tendon by angiogenesis. Here, in this study, a system that NO-loaded metal–organic frameworks (MOFs) encapsulated in polycaprolactone (PCL)/gelatin (Gel) aligned coaxial scaffolds (NMPGA) is designed and prepared for tendon repair. In this system, NO is able to be released in vitro at a slow and stable average speed of 1.67 nM h−1 as long as 15 d without a burst release stage in the initial 48 h. Furthermore, NMPGA can not only improve the tubular formation capability of endothelial cells in vitro but also obviously increase the blood perfusion near the injured tendon in vivo, leading to accelerating the maturity of collagen and recovery of biomechanical strength of the regenerated tendon tissue. As a NO-loaded MOFs therapeutic system, NMPGA can promote tendon regeneration in a shorter healing period with better biomechanical properties in comparison with control group by angiogenesis. Therefore, this study not only provides a promising scaffold for tendon regeneration, but also paves a new way to develop a NO-based therapy for biomedical application in the future.


Highlights:


1 A system that NO-loaded metal–organic frameworks encapsulated in PCL/Gel aligned coaxial scaffold is successfully constructed.
2 The system enables to release NO slowly (1.67 nM h−1) and stably in a long period (15 d) without a burst release in the initial 48 h.
3 The scaffold can promote the regeneration of the injured tendon with maturer collagen fibers and better mechanical properties by angiogenesis.

Keywords

Nitric oxide Metal–organic frameworks Tendon Tissue regeneration Angiogenesis
Chen, Jun, Dandan Sheng, Ting Ying, Haojun Zhao, Jian Zhang, Yunxia Li, He Xu, and Shiyi Chen. 2020. “MOFs-Based Nitric Oxide Therapy for Tendon Regeneration”. Nano-Micro Letters 13 (November):23. https://doi.org/10.1007/s40820-020-00542-x.
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