Issue

Vol. 5 No. 1 (2013)

Progress of Microfluidics for Biology and Medicine

https://doi.org/10.1007/BF03354852
Jingdong Chen
Science and Technology on Micro/Nano Fabrication Laboratory, Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China
Di Chen
Science and Technology on Micro/Nano Fabrication Laboratory, Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China
Yao Xie
Science and Technology on Micro/Nano Fabrication Laboratory, Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China
Tao Yuan
Science and Technology on Micro/Nano Fabrication Laboratory, Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China
Xiang Chen
Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China

Corresponding Author: Di Chen

dchen@sjtu.edu.cn

Nano-Micro Letters, Vol. 5 No. 1 (2013), Article Number: 66-80

Abstract

Microfluidics has been considered as a potential technology to miniaturize the conventional equipments and technologies. It offers advantages in terms of small volume, low cost, short reaction time and highthroughput. The applications in biology and medicine research and related areas are almost the most extensive and profound. With the appropriate scale that matches the scales of cells, microfluidics is well positioned to contribute significantly to cell biology. Cell culture, fusion and apoptosis were successfully performed in microfluidics. Microfluidics provides unique opportunities for rare circulating tumor cells isolation and detection from the blood of patients, which furthers the discovery of cancer stem cell biomarkers and expands the understanding of the biology of metastasis. Nucleic acid amplification in microfluidics has extended to single-molecule, high-throughput and integration treatment in one chip. DNA computer which is based on the computational model of DNA biochemical reaction will come into practice from concept in the future. In addition, microfluidics offers a versatile platform for protein-protein interactions, protein crystallization and high-throughput screening. Although microfluidics is still in its infancy, its great potential has already been demonstrated and will provide novel solutions to the high-throughput applications.

Keywords

Microfluidics Lab-on-a-chip Droplet High-throughput Cell Nucleic acid amplification
Chen, Jingdong, Di Chen, Yao Xie, Tao Yuan, and Xiang Chen. 2013. “Progress of Microfluidics for Biology and Medicine”. Nano-Micro Letters 5 (1):66-80. https://doi.org/10.1007/BF03354852.
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