Issue

Vol. 12 (2020)

A Review on Artificial Micro/Nanomotors for Cancer-Targeted Delivery, Diagnosis, and Therapy

https://doi.org/10.1007/s40820-019-0350-5
Jiajia Wang
School of Chemistry and Environment, Guangzhou Key Laboratory of Materials for Energy Conversion and Storage, Guangdong Provincial Engineering Technology Research Center for Materials for Energy Conversion and Storage, South China Normal University, Guangzhou 510006, People’s Republic of China
Renfeng Dong
School of Chemistry and Environment, Guangzhou Key Laboratory of Materials for Energy Conversion and Storage, Guangdong Provincial Engineering Technology Research Center for Materials for Energy Conversion and Storage, South China Normal University, Guangzhou 510006, People’s Republic of China
Huiying Wu
School of Chemistry and Environment, Guangzhou Key Laboratory of Materials for Energy Conversion and Storage, Guangdong Provincial Engineering Technology Research Center for Materials for Energy Conversion and Storage, South China Normal University, Guangzhou 510006, People’s Republic of China
Yuepeng Cai
School of Chemistry and Environment, Guangzhou Key Laboratory of Materials for Energy Conversion and Storage, Guangdong Provincial Engineering Technology Research Center for Materials for Energy Conversion and Storage, South China Normal University, Guangzhou 510006, People’s Republic of China
Biye Ren
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, People’s Republic of China

Corresponding Author: Biye Ren

mcbyren@scut.edu.cn

Nano-Micro Letters, Vol. 12 (2020), Article Number: 11

Abstract

Micro/nanomotors have been extensively explored for efficient cancer diagnosis and therapy, as evidenced by significant breakthroughs in the design of micro/nanomotors-based intelligent and comprehensive biomedical platforms. Here, we demonstrate the recent advances of micro/nanomotors in the field of cancer-targeted delivery, diagnosis, and imaging-guided therapy, as well as the challenges and problems faced by micro/nanomotors in clinical applications. The outlook for the future development of micro/nanomotors toward clinical applications is also discussed. We hope to highlight these new advances in micro/nanomotors in the field of cancer diagnosis and therapy, with the ultimate goal of stimulating the successful exploration of intelligent micro/nanomotors for future clinical applications.


Highlights:


1 Recent advances of micro/nanomotors in the field of cancer-targeted delivery, diagnosis, and imaging-guided therapy are summarized.
2 Challenges and outlook for the future development of micro/nanomotors toward clinical applications are discussed.

Keywords

Micro/nanomotors Cancer Drug delivery Diagnosis Imaging
Wang, Jiajia, Renfeng Dong, Huiying Wu, Yuepeng Cai, and Biye Ren. 2019. “A Review on Artificial Micro/Nanomotors for Cancer-Targeted Delivery, Diagnosis, and Therapy”. Nano-Micro Letters 12 (December):11. https://doi.org/10.1007/s40820-019-0350-5.
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References
  1. C. Allemani, T. Matsuda, V. Di Carlo, Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. The Lancet 391, 1023–1075 (2018). https://doi.org/10.1016/s0140-6736(17)33326-3
  2. H. Chen, Z. Gu, H. An, C. Chen, J. Chen et al., Precise nanomedicine for intelligent therapy of cancer. Sci. China Chem. 61, 1503–1552 (2018). https://doi.org/10.1007/s11426-018-9397-5
  3. A. Wicki, D. Witzigmann, V. Balasubramanian, J. Huwyler, Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications. J. Control Release 200, 138–157 (2015). https://doi.org/10.1016/j.jconrel.2014.12.030
  4. K.K. Chan, S.H.K. Yap, K.T. Yong, Biogreen synthesis of carbon dots for biotechnology and nanomedicine applications. Nano-Micro Lett. 10, 72 (2018). https://doi.org/10.1007/s40820-018-0223-3
  5. Q. Zhao, H. Cui, Y. Wang, X. Du, Microfluidic platforms toward rational material fabrication for biomedical applications. Small 1903798 (2019). https://doi.org/10.1002/smll.201903798
  6. Y. Wang, H. Cui, Q. Zhao, X. Du, Chameleon-inspired structural-color actuators. Matter 1, 626–638 (2019). https://doi.org/10.1016/j.matt.2019.05.012
  7. Y. Hu, S. Mignani, J.P. Majoral, M. Shen, X. Shi, Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy. Chem. Soc. Rev. 47, 1874–1900 (2018). https://doi.org/10.1039/c7cs00657h
  8. K.D. Wegner, N. Hildebrandt, Quantum dots: bright and versatile in vitro and in vivo fluorescence imaging biosensors. Chem. Soc. Rev. 44, 4792–4834 (2015). https://doi.org/10.1039/c4cs00532e
  9. T. Sun, F. Ai, G. Zhu, F. Wang, Upconversion in nanostructured materials: from optical tuning to biomedical applications. Chem. Asian J. 13, 373–385 (2018). https://doi.org/10.1002/asia.201701660
  10. X. Du, H. Cui, Q. Zhao, J. Wang, H. Chen, Y. Wang, Inside-out 3D reversible ion-triggered shape-morphing hydrogels. Research 6398296 (2019). https://doi.org/10.34133/2019/6398296
  11. Y. Xia, W. Li, C.M. Cobley, J. Chen, X. Xia et al., Gold nanocages: from synthesis to theranostic applications. Acc. Chem. Res. 44, 914 (2011). https://doi.org/10.1021/ar200061q
  12. J. Wang, Nanomachines: Fundamentals and Applications (Wiley, Weinheim, 2013)
  13. M. Safdar, S.U. Khan, J. Jänis, Progress toward catalytic micro- and nanomotors for biomedical and environmental applications. Adv. Mater. 1703660 (2018). https://doi.org/10.1002/adma.201703660
  14. T.E. Mallouk, A Sen (2009) Powering nanorobots. Sci. Am. 300, 72–77 (2009)
  15. T. Xu, L.P. Xu, X. Zhang, Ultrasound propulsion of micro-/nanomotors. Appl. Mater. Today 9, 493–503 (2017). https://doi.org/10.1016/j.apmt.2017.07.011
  16. K.E. Peyer, S. Tottori, F. Qiu, L. Zhang, B.J. Nelson, Magnetic helical micromachines. Chem. Eur. J. 19, 28–38 (2013). https://doi.org/10.1002/chem.201203364
  17. Z. Wu, Y. Wu, W. He, X. Lin, J. Sun, Q. He, Self-propelled polymer-based multilayer nanorockets for transportation and drug release. Angew. Chem. Int. Ed. 52, 7000–7003 (2013). https://doi.org/10.1002/anie.201301643
  18. H. Chen, Q. Zhao, Y. Wang, S. Mu, H. Cui, J. Wang, T. Kong, X. Du, Near-infrared light-driven controllable motions of gold-hollow-microcone array. ACS Appl. Mater. Interfaces 11, 15927–15935 (2019). https://doi.org/10.1021/acsami.9b03576
  19. H. Chen, Q. Zhao, X. Du, Light-powered micro/nanomotors. Micromachines 9, 41 (2018). https://doi.org/10.3390/mi9020041
  20. X. Ma, A.C. Hortelão, T. Patiño, S. Sánchez, Enzyme catalysis to power micro/nanomachines. ACS Nano 10, 9111–9122 (2016). https://doi.org/10.1021/acsnano.6b04108
  21. Y. Yang, X. Song, X. Li, Z. Chen, C. Zhou, Q. Zhou, Y. Chen, Recent progress in biomimetic additive manufacturing technology: from materials to functional structures. Adv. Mater. 1706539 (2018). https://doi.org/10.1002/adma.201706539
  22. X. Wang, J. Feng, Y. Bai, Q. Zhang, Y. Yin, Synthesis, properties, and applications of hollow micro-/nanostructures. Chem. Rev. 116, 10983–11060 (2016). https://doi.org/10.1021/acs.chemrev.5b00731
  23. X. Pang, C. Wan, M. Wang, Z. Lin, Strictly biphasic soft and hard Janus structures: synthesis, properties, and applications. Angew. Chem. Int. Ed. 53, 5524–5538 (2014). https://doi.org/10.1002/anie.201309352
  24. H. Ning, Y. Zhang, H. Zhu, A. Ingham, G. Huang, Y. Mei, A. Solovev, Geometry design, principles and assembly of micromotors. Micromachines 9, 75 (2018). https://doi.org/10.3390/mi9020075
  25. K. Kim, J. Guo, Z. Liang, D. Fan, Artificial micro/nanomachines for bioapplications: biochemical delivery and diagnostic sensing. Adv. Funct. Mater. 1705867 (2018). https://doi.org/10.1002/adfm.201705867
  26. J. Li, B. Esteban-Fernández de Ávila, W. Gao, L. Zhang, J. Wang, Micro/nanorobots for biomedicine: delivery, surgery, sensing, and detoxification. Sci. Robot 2, 6431 (2017). https://doi.org/10.1126/scirobotics.aam6431
  27. Z. Wu, X. Lin, T. Si, Q. He, Recent progress on bioinspired self-propelled micro/nanomotors via controlled molecular self-assembly. Small 12, 3080–3093 (2016). https://doi.org/10.1002/smll.201503969
  28. B. Esteban-Fernández de Ávila, W. Gao, E. Karshalev, L. Zhang, J. Wang, Cell-like micromotors. Acc. Chem. Res. 51, 1901–1910 (2018). https://doi.org/10.1021/acs.accounts.8b00202
  29. S. Pané, J. Puigmartí-Luis, C. Bergeles, X.Z. Chen, E. Pellicer et al., Imaging technologies for biomedical micro- and nanoswimmers. Adv. Mater. Technol. 4, 1800575 (2018). https://doi.org/10.1002/admt.201800575
  30. C. Gao, Z. Lin, X. Lin, Q. He, Cell membrane-camouflaged colloid motors for biomedical applications. Adv. Therap. 1, 1800056 (2018). https://doi.org/10.1002/adtp.201800056
  31. L. Xu, F. Mou, H. Gong, M. Luo, J. Guan, Light-driven micro/nanomotors: from fundamentals to applications. Chem. Soc. Rev. 46, 6905–6926 (2017). https://doi.org/10.1039/C7CS00516D
  32. R. Dong, Y. Cai, Y. Yang, W. Gao, B. Ren, Photocatalytic micro/nanomotors: from construction to applications. Acc. Chem. Res. 51, 1940–1947 (2018). https://doi.org/10.1021/acs.accounts.8b00249
  33. W.F. Paxton, K.C. Kistler, C.C. Olmeda, A. Sen, S.K. Angelo et al., Catalytic nanomotors: autonomous movement of striped nanorods. J. Am. Chem. Soc. 126, 13424–13431 (2004). https://doi.org/10.1021/ja047697z
  34. J. Guo, J.J. Gallegos, A.R. Tom, D. Fan, Electric-field-guided precision manipulation of catalytic nanomotors for cargo delivery and powering nanoelectromechanical devices. ACS Nano 12, 1179–1187 (2018). https://doi.org/10.1021/acsnano.7b06824
  35. J. Wang, Z. Xiong, X. Zhan, B. Dai, J. Zheng, J. Liu, J. Tang, A silicon nanowire as a spectrally tunable light-driven nanomotor. Adv. Mater. 170145 (2017). https://doi.org/10.1002/adma.201701451
  36. B. Xu, B. Zhang, L. Wang, G. Huang, Y. Mei, Tubular micro/nanomachines: from the basics to recent advances. Adv. Funct. Mater. 1705872 (2018). https://doi.org/10.1002/adfm.201705872
  37. Z. Tian, L. Zhang, Y. Fang, B. Xu, S. Tang et al., Deterministic self-rolling of ultrathin nanocrystalline diamond nanomembranes for 3D tubular/helical architecture. Adv. Mater. 1604572 (2017). https://doi.org/10.1002/adma.201604572
  38. F. Zha, T. Wang, M. Luo, J. Guan, Tubular micro/nanomotors: propulsion mechanisms, fabrication techniques and applications. Micromachines 9, 78 (2018). https://doi.org/10.3390/mi9020078
  39. J. Jiao, D. Xu, Y. Liu, W. Zhao, J. Zhang, T. Zheng, H. Feng, X. Ma, Mini-emulsion fabricated magnetic and fluorescent hybrid Janus micro-motors. Micromachines 9, 83 (2018). https://doi.org/10.3390/mi9020083
  40. Y. Ji, X. Lin, H. Zhang, Y. Wu, J. Li, Q. He, Thermoresponsive polymer brush modulation on the direction of motion of phoretically driven janus micromotors Angew. Chem. Int. Ed. 58, 4184–4188 (2019). https://doi.org/10.1002/anie.201812860
  41. V. Sridhar, B.-W. Park, M. Sitti, Light-driven janus hollow mesoporous TiO2–Au microswimmers. Adv. Funct. Mater. 1704902 (2018). https://doi.org/10.1002/adfm.201704902
  42. F. Peng, Y. Tu, Y. Men, J.C.M. van Hest, D.A. Wilson, Supramolecular adaptive nanomotors with magnetotaxis behavior. Adv. Mater. 29, 1604996 (2016). https://doi.org/10.1002/adma.201604996
  43. J. Li, X. Yu, M. Xu, W. Liu, E. Sandraz, H. Lan, J. Wang, S.M. Cohen, Metal-organic frameworks as micromotors with tunable engines and brakes. J. Am. Chem. Soc. 139, 611–614 (2016). https://doi.org/10.1021/jacs.6b11899
  44. L. Wang, H. Zhu, Y. Shi, Y. Ge, X. Feng, R. Liu, Y. Li, Y. Ma, L.J.N. Wang, Novel catalytic micromotor of porous zeolitic imidazolate framework-67 for precise drug delivery. Nanoscale 10, 11384–11391 (2018). https://doi.org/10.1039/C8NR02493F
  45. H. Wang, M. Pumera, Fabrication of micro/nanoscale motors. Chem. Rev. 115, 8704–8735 (2015). https://doi.org/10.1021/acs.chemrev.5b00047
  46. D. Ahmed, T. Baasch, B. Jang, S. Pané, J. Dual, B.J. Nelson, Artificial swimmers propelled by acoustically activated flagella. Nano Lett. 16, 4968–4974 (2016). https://doi.org/10.1021/acs.nanolett.6b01601
  47. J. Katuri, W.E. Uspal, J. Simmchen, A. Miguel-López, S. Sánchez, Cross-stream migration of active particles. Sci. Adv. 4, 1755 (2018). https://doi.org/10.1126/sciadv.aao1755
  48. W. Gao, B.E.-F. de Ávila, L. Zhang, J. Wang, Targeting and isolation of cancer cells using micro/nanomotors. Adv. Drug Del. Rev. 125, 94–101 (2018). https://doi.org/10.1016/j.addr.2017.09.002
  49. M. Hansen-Bruhn, B.E.-F. de Ávila, M. Beltrán-Gastélum, J. Zhao, D.E. Ramírez-Herrera et al., Active intracellular delivery of a Cas9/sgRNA complex using ultrasound-propelled nanomotors. Angew. Chem. Int. Ed. 57, 2657–2661 (2018). https://doi.org/10.1002/anie.201713082
  50. W. Wang, Z. Wu, X. Lin, T. Si, Q. He, Gold-nanoshell-functionalized polymer nanoswimmer for photomechanical poration of single-cell membrane. J. Am. Chem. Soc. 141, 6601–6608 (2019). https://doi.org/10.1021/jacs.8b13882
  51. B. Jurado-Sanchez, M. Pacheco, J. Rojo, A. Escarpa, Magnetocatalytic graphene quantum dots janus micromotors for bacterial endotoxin detection. Angew. Chem. Int. Ed. 56, 6957–6961 (2017). https://doi.org/10.1002/anie.201701396
  52. A. Halder, Y. Sun, Biocompatible propulsion for biomedical micro/nano robotics. Biosens. Bioelectron. 139, 111334 (2019). https://doi.org/10.1016/j.bios.2019.111334
  53. S. Mitragotri, P.A. Burke, R. Langer, Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies. Nat. Rev. Drug Discov. 13, 655–672 (2014). https://doi.org/10.1038/nrd4363
  54. M. Medina-Sanchez, L. Schwarz, A.K. Meyer, F. Hebenstreit, O.G. Schmidt, Cellular cargo delivery: toward assisted fertilization by sperm-carrying micromotors. Nano Lett. 16, 555–561 (2016). https://doi.org/10.1021/acs.nanolett.5b04221
  55. S.K. Srivastava, G. Clergeaud, T.L. Andresen, A. Boisen, Micromotors for drug delivery in vivo: the road ahead. Adv. Drug Deliv. Rev. 138, 41–55 (2019). https://doi.org/10.1016/j.addr.2018.09.005
  56. M. Medina-Sánchez, H. Xu, O.G. Schmidt, Micro-and nano-motors: the new generation of drug carriers. Therap. Deliv. 9, 303–316 (2018). https://doi.org/10.4155/tde-2017-0113
  57. W. Gao, J. Wang, Synthetic micro/nanomotors in drug delivery. Nanoscale 6, 10486–10494 (2014). https://doi.org/10.1039/C4NR03124E
  58. Y. Wu, X. Lin, Z. Wu, H. Möhwald, Q. He, Self-propelled polymer multilayer janus capsules for effective drug delivery and light-triggered release. ACS Appl. Mater. Interfaces. 6, 10476–10481 (2014). https://doi.org/10.1021/am502458h
  59. L. Ming, F. Youzeng, W. Tingwei, G. Jianguo, Micro‐/nanorobots at work in active drug delivery. Adv. Funct. Mater. 1706100 (2018). https://doi.org/10.1002/adfm.201706100
  60. T.P. Szatrowski, CFJCR Nathan, Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res. 51, 794–798 (1991). https://doi.org/10.1016/0304-3835(91)90094-x
  61. K. Villa, L. Krejčová, F. Novotný, Z. Heger, Z. Sofer, M. Pumera, Cooperative multifunctional self-propelled paramagnetic microrobots with chemical handles for cell manipulation and drug delivery. Adv. Funct. Mater. 1804343 (2018). https://doi.org/10.1002/adfm.201804343
  62. A.C. Hortelão, T. Patiño, A. Perez-Jiménez, À. Blanco, S. Sánchez, Enzyme-powered nanobots enhance anticancer drug delivery. Adv. Funct. Mater. 1705086 (2017). https://doi.org/10.1002/adfm.201705086
  63. B. Khezri, S.M. Beladi Mousavi, L. Krejčová, Z. Heger, Z. Sofer, M.J.A.F.M. Pumera, Ultrafast electrochemical trigger drug delivery mechanism for nanographene micromachines. Adv. Funct. Mater. 1806696 (2018). https://doi.org/10.1002/adfm.201806696
  64. S. Gao, J. Hou, J. Zeng, J.J. Richardson, Z. Gu et al., Superassembled biocatalytic porous framework micromotors with reversible and sensitive pH-speed regulation at ultralow physiological H2O2 concentration. Adv. Funct. Mater. 1808900 (2019). https://doi.org/10.1002/adfm.201808900
  65. H. Xu, M. Medina-Sánchez, V. Magdanz, L. Schwarz, F. Hebenstreit, O.G. Schmidt, Sperm-hybrid micromotor for targeted drug delivery. ACS Nano 12, 327–337 (2018). https://doi.org/10.1021/acsnano.7b06398
  66. B. Esteban-Fernández de Ávila, C. Angell, F. Soto, M.A. Lopez-Ramirez, D.F. Báez, S. Xie, J. Wang, Y. Chen, Acoustically propelled nanomotors for intracellular siRNA delivery. ACS Nano 10, 4997–5005 (2016). https://doi.org/10.1021/acsnano.6b01415
  67. Z. Wu, L. Li, Y. Yang, P. Hu, Y. Li, S.Y. Yang, L. Wang, W. Gao, A microrobotic system guided by photoacoustic computed tomography for targeted navigation in intestines in vivo. Sci. Robot. 4, eaax0613 (2019). https://doi.org/10.1126/scirobotics.aax0613
  68. C.Y. Wen, H.Y. Xie, Z.L. Zhang, L.L. Wu, J. Hu, M. Tang, M. Wu, D.W. Pang, Fluorescent/magnetic micro/nano-spheres based on quantum dots and/or magnetic nanoparticles: preparation, properties, and their applications in cancer studies. Nanoscale 8, 12406–12429 (2016). https://doi.org/10.1039/c5nr08534a
  69. S.A. Soper, K. Brown, A. Ellington, B. Frazier, G. Garcia-Manero et al., Point-of-care biosensor systems for cancer diagnostics/prognostics. Biosens. Bioelectron. 21, 1932–1942 (2006). https://doi.org/10.1016/j.bios.2006.01.006
  70. N.L. Henry, D.F. Hayes, Cancer biomarkers. Mol. Oncol. 6, 140–146 (2012). https://doi.org/10.1016/j.molonc.2012.01.010
  71. W. Zhou, Q. Li, H. Liu, J. Yang, D. Liu, Building electromagnetic hot spots in living cells via target-triggered nanoparticle dimerization. ACS Nano 11, 3532–3541 (2017). https://doi.org/10.1021/acsnano.7b00531
  72. J.J. Fenton, M.S. Weyrich, S. Durbin, Y. Liu, H. Bang, J. Melnikow, Prostate-specific antigen-based screening for prostate cancer: evidence report and systematic review for the US preventive services task force. JAMA 319, 1914–1931 (2018). https://doi.org/10.1001/jama.2018.3712
  73. Y. Lu, M. Zhu, W. Li, B. Lin, X. Dong, Y. Chen, X. Xie, J. Guo, M. Li, Alpha fetoprotein plays a critical role in promoting metastasis of hepatocellular carcinoma cells. J. Cell Mol. Med. 20, 549–558 (2016). https://doi.org/10.1111/jcmm.12745
  74. H. Wang, M. Pumera, Micro/nanomachines and living biosystems: from simple interactions to microcyborgs. Adv. Funct. Mater. 1705421 (2018). https://doi.org/10.1002/adfm.201705421
  75. C.Y. Wen, L.L. Wu, Z.L. Zhang, Y.L. Liu, S.Z. Wei et al., Quick-response magnetic nanospheres for rapid, efficient capture and sensitive detection of circulating tumor cells. ACS Nano 8, 941–949 (2014). https://doi.org/10.1021/nn405744f
  76. S. Riethdorf, H. Fritsche, V. Muller, T. Rau, C. Schindlbeck et al., Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the Cell Search system. Clin. Cancer Res. 13, 920–928 (2007). https://doi.org/10.1158/1078-0432.CCR-06-1695
  77. N. Beije, A. Jager, S. Sleijfer, Circulating tumor cell enumeration by the Cell Search system: the clinician’s guide to breast cancer treatment? Cancer Treat. Rev. 41, 144–150 (2015). https://doi.org/10.1016/j.ctrv.2014.12.008
  78. E. Andreopoulou, L.Y. Yang, K.M. Rangel, J.M. Reuben, L. Hsu et al., Comparison of assay methods for detection of circulating tumor cells in metastatic breast cancer: adnaGen AdnaTest BreastCancer Select/DetectTM versus Veridex Cell SearchTM system. Int. J. Cancer 130, 1590–1597 (2012). https://doi.org/10.1002/ijc.26111
  79. D. Kagan, R. Laocharoensuk, M. Zimmerman, C. Clawson, S. Balasubramanian et al., Rapid delivery of drug carriers propelled and navigated by catalytic nanoshuttles. Small 6, 2741–2747 (2010). https://doi.org/10.1002/smll.201001257
  80. R.L.J. Burdick, P.M. Wheat, J.D. Posner, J. Wang, Synthetic nanomotors in microchannel networks: directional microchip motion and controlled manipulation of cargo. J. Am. Chem. Soc. 130, 8164–8165 (2008). https://doi.org/10.1021/ja803529u
  81. S. Sundararajan, S. Sengupta, M.E. Ibele, A. Sen, Drop-off of colloidal cargo transported by catalytic Pt-Au nanomotors via photochemical stimuli. Small 6, 1479–1482 (2010). https://doi.org/10.1002/smll.201000227
  82. Y. Ding, F. Qiu, X. Casadevall i Solvas, F. Chiu, B. Nelson, A. de Mello, Microfluidic-based droplet and cell manipulations using artificial bacterial flagella. Micromachines 7(2), 25 (2016). https://doi.org/10.3390/mi7020025
  83. L. Zhang, K.E. Peyer, B.J. Nelson, Artificial bacterial flagella for micromanipulation. Lab Chip 10, 2203–2215 (2010). https://doi.org/10.1039/c004450b
  84. S. Balasubramanian, D. Kagan, C.M. Jack Hu, S. Campuzano, M.J. Lobo-Castañon et al., Micromachine-enabled capture and isolation of cancer cells in complex media. Angew. Chem. Int. Ed. 50, 4161–4164 (2011). https://doi.org/10.1002/anie.201100115
  85. X. Zhang, C. Chen, J. Wu, H. Ju, Bubble-propelled jellyfish-like micromotors for DNA sensing. ACS Appl. Mater. Interfaces. 11, 13581–13588 (2019). https://doi.org/10.1021/acsami.9b00605
  86. Y.X. Chen, K.J. Huang, K.X. Niu, Recent advances in signal amplification strategy based on oligonucleotide and nanomaterials for microRNA detection-a review. Biosens. Bioelectron. 99, 612–624 (2018). https://doi.org/10.1016/j.bios.2017.08.036
  87. A.D. Castaneda, N.J. Brenes, A. Kondajji, R.M. Crooks, Detection of microRNA by electrocatalytic amplification: a general approach for single-particle biosensing. J. Am. Chem. Soc. 139, 7657–7664 (2017). https://doi.org/10.1021/jacs.7b03648
  88. W. Lu, Y. Chen, Z. Liu, W. Tang, Q. Feng, J. Sun, X. Jiang, Quantitative detection of microRNA in one step via next generation magnetic relaxation switch sensing. ACS Nano 10, 6685–6692 (2016). https://doi.org/10.1021/acsnano.6b01903
  89. X. Zhao, L. Xu, M. Sun, W. Ma, X. Wu, H. Kuang, L. Wang, C. Xu, Gold-quantum dot core-satellite assemblies for lighting up microRNA in vitro and in vivo. Small 12, 4662–4668 (2016). https://doi.org/10.1002/smll.201503629
  90. S. Li, L. Xu, W. Ma, X. Wu, M. Sun et al., Dual-mode ultrasensitive quantification of microRNA in living cells by chiroplasmonic nanopyramids self-assembled from gold and upconversion nanoparticles. J. Am. Chem. Soc. 138, 306–312 (2016). https://doi.org/10.1021/jacs.5b10309
  91. D.Á.B. Esteban-Fernández, A. Martín, F. Soto, M.A. Lopez-Ramirez, S. Campuzano et al., Single cell real-time miRNAs sensing based on nanomotors. ACS Nano 9, 6756–6764 (2015). https://doi.org/10.1021/acsnano.5b02807
  92. T.H. Shin, Y. Choi, S. Kim, JJCSR Cheon, Recent advances in magnetic nanoparticle-based multi-modal imaging. Chem. Soc. Rev. 44, 4501–4516 (2015). https://doi.org/10.1039/c4cs00345d
  93. J.Y. Zhao, G. Chen, Y.P. Gu, R. Cui, Z.L. Zhang, Z.L. Yu, B. Tang, Y.F. Zhao, D.W. Pang, Ultrasmall magnetically engineered Ag2Se quantum dots for instant efficient labeling and whole-body high-resolution multimodal real-time tracking of cell-derived microvesicles. J. Am. Chem. Soc. 138, 1893–1903 (2016). https://doi.org/10.1021/jacs.5b10340
  94. L. Wu, A. Mendoza-Garcia, Q. Li, S. Sun, Organic phase syntheses of magnetic nanoparticles and their applications. Chem. Rev. 116, 10473–10512 (2016). https://doi.org/10.1021/acs.chemrev.5b00687
  95. J. Xie, K. Chen, H.Y. Lee, C. Xu, A.R. Hsu et al., Ultrasmall c(RGDyK)-coated Fe3O4 nanoparticles and their specific targeting to integrin alpha(v)beta3-rich tumor cells. J. Am. Chem. Soc. 130, 7542–7543 (2008). https://doi.org/10.1021/ja802003h
  96. X. Yan, Q. Zhou, M. Vincent, Y. Deng, J. Yu et al., Multifunctional biohybrid magnetite microrobots for imaging-guided therapy. Sci. Robot. 2, 1155 (2017). https://doi.org/10.1126/scirobotics.aaq1155
  97. M. Wan, H. Chen, Q. Wang, Q. Niu, P. Xu, Y. Yu, T. Zhu, C. Mao, J. Shen, Bio-inspired nitric-oxide-driven nanomotor. Nat. Commun. 10, 966 (2019). https://doi.org/10.1038/s41467-019-08670-8
  98. H. Ceylan, I.C. Yasa, O. Yasa, A.F. Tabak, J. Giltinan, M. Sitti, 3D-printed biodegradable microswimmer for theranostic cargo delivery and release. ACS Nano 13, 3353–3362 (2019). https://doi.org/10.1021/acsnano.8b09233
  99. G.F. Luo, W.H. Chen, Q. Lei, W.X. Qiu, Y.X. Liu, Y.J. Cheng, X.Z. Zhang, A triple-collaborative strategy for high-performance tumor therapy by multifunctional mesoporous silica-coated gold nanorods. Adv. Funct. Mater. 26, 4339–4350 (2016). https://doi.org/10.1002/adfm.201505175
  100. W.H. Chen, G.F. Luo, W.X. Qiu, Q. Lei, L.H. Liu, S.B. Wang, X.Z.J.B. Zhang, Mesoporous silica-based versatile theranostic nanoplatform constructed by layer-by-layer assembly for excellent photodynamic/chemo therapy. Biomaterials 117, 54–65 (2016). https://doi.org/10.1016/j.biomaterials.2016.11.057
  101. Z. Zhang, J. Wang, C.J. Chen, Near-infrared light-mediated nanoplatforms for cancer thermo-chemotherapy and optical imaging. Adv. Mater. 25, 3869–3880 (2013). https://doi.org/10.1002/adma.201301890
  102. C. Li, Y. Zhang, Z. Li, E. Mei, J. Lin et al., Theranostics: light-responsive biodegradable nanorattles for cancer theranostics. Adv. Mater. 30, 1870049 (2018). https://doi.org/10.1002/adma.201870049
  103. P.P. Yang, Y.G. Zhai, G.B. Qi, Y.X. Lin, Q. Luo et al., NIR light propulsive janus-like nanohybrids for enhanced photothermal tumor therapy. Small 12, 5423–5430 (2016). https://doi.org/10.1002/smll.201601965
  104. H. Choi, G.H. Lee, K.S. Kim, S.K. Hahn, Light-guided nanomotor systems for autonomous photothermal cancer therapy. ACS Appl. Mater. Interfaces 10, 2338–2346 (2017). https://doi.org/10.1021/acsami.7b16595
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