Issue

Vol. 12 (2020)

Metal–Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications

https://doi.org/10.1007/s40820-020-00423-3
Yujia Sun
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, People’s Republic of China
Liwei Zheng
Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA
Yu Yang
Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, UF Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA
Xu Qian
Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, The Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou 310022, People’s Republic of China
Ting Fu
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, People’s Republic of China
Xiaowei Li
Center for Research at Bio/Nano Interface, Department of Chemistry and Department of Physiology and Functional Genomics, UF Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA
Zunyi Yang
Foundation for Applied Molecular Evolution, 13709 Progress Boulevard, Alachua, FL 32615, USA
He Yan
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, People’s Republic of China
Cheng Cui
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, People’s Republic of China
Weihong Tan
Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, People’s Republic of China

Corresponding Author: Weihong Tan

tan@hnu.edu.cn

Nano-Micro Letters, Vol. 12 (2020), Article Number: 103

Abstract

Investigation of metal–organic frameworks (MOFs) for biomedical applications has attracted much attention in recent years. MOFs are regarded as a promising class of nanocarriers for drug delivery owing to well-defined structure, ultrahigh surface area and porosity, tunable pore size, and easy chemical functionalization. In this review, the unique properties of MOFs and their advantages as nanocarriers for drug delivery in biomedical applications were discussed in the first section. Then, state-of-the-art strategies to functionalize MOFs with therapeutic agents were summarized, including surface adsorption, pore encapsulation, covalent binding, and functional molecules as building blocks. In the third section, the most recent biological applications of MOFs for intracellular delivery of drugs, proteins, and nucleic acids, especially aptamers, were presented. Finally, challenges and prospects were comprehensively discussed to provide context for future development of MOFs as efficient drug delivery systems.


Highlights:


1 Recent advances in biomedical applications of metal–organic framework (MOF) nanocarriers for drug delivery are summarized.
2 State-of-the-art strategies to functionalize MOFs with therapeutic agents, as well as their merits and drawbacks, are comprehensively discussed.

Keywords

Metal–organic frameworks Drugs Biomolecules Drug delivery Biomedical applications
Sun, Yujia, Liwei Zheng, Yu Yang, Xu Qian, Ting Fu, Xiaowei Li, Zunyi Yang, He Yan, Cheng Cui, and Weihong Tan. 2020. “Metal–Organic Framework Nanocarriers for Drug Delivery in Biomedical Applications”. Nano-Micro Letters 12 (May):103. https://doi.org/10.1007/s40820-020-00423-3.
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