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Vol. 8 No. 2 (2016)

Pod-Like Supramicelles with Multicompartment Hydrophobic Cores Prepared by Self-Assembly of Modified Chitosan

https://doi.org/10.1007/s40820-015-0070-4
Yiming Wang
State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, People’s Republic of China
Jie Wang
State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, People’s Republic of China
Tongshuai Wang
State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, People’s Republic of China
Yisheng Xu
State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, People’s Republic of China
Lei Shi
Firmenich Aromatics (China) Co., Ltd., Shanghai 201108, People’s Republic of China
Yongtao Wu
Firmenich Aromatics (China) Co., Ltd., Shanghai 201108, People’s Republic of China
Li Li
State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, People’s Republic of China
Xuhong Guo
State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, People’s Republic of China

Corresponding Author: Xuhong Guo

guoxuhong@ecust.edu.cn

Nano-Micro Letters, Vol. 8 No. 2 (2016), Article Number: 151-156

Abstract

In this paper, pod-like supramicelles with multicompartment hydrophobic cores were prepared by self-assembly of amphiphilic N-phthaloylchitosan-g-poly(N-vinylcaprolactam) (PHCS-g-PNVCL) in aqueous medium. The employed biocompatible amphiphilic polymer was synthesized by grafting the carboxyl terminated poly(N-vinylcaprolactam) (PNVCL-COOH) chains onto N-phthaloylchitosan (PHCS) backbone. 1H NMR and FTIR results confirmed the molecular structure of the copolymers. The morphology of the supramicelles assembled by PHCS-g-PNVCL was revealed by means of TEM and polarized light microscope. In solution, the supramicelles were very stable as monitored by DLS and zeta potential measurements. Temperature and pH presented significant influences on the size and size distribution of the supramicelles. These supramicelles with multicompartment hydrophobic cores should be ideal biomimetic systems with promising applications in drug delivery.

Keywords

Chitosan Graft copolymers Amphiphiles Self-assembly Multicompartment supramicelles
Wang, Yiming, Jie Wang, Tongshuai Wang, Yisheng Xu, Lei Shi, Yongtao Wu, Li Li, and Xuhong Guo. 2015. “Pod-Like Supramicelles With Multicompartment Hydrophobic Cores Prepared by Self-Assembly of Modified Chitosan”. Nano-Micro Letters 8 (2):151-56. https://doi.org/10.1007/s40820-015-0070-4.
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