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Vol. 11 (2019)

Manganese-Zeolitic Imidazolate Frameworks-90 with High Blood Circulation Stability for MRI-Guided Tumor Therapy

https://doi.org/10.1007/s40820-019-0292-y
Zhenqi Jiang
Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, People’s Republic of China
Bo Yuan
Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, People’s Republic of China
Nianxiang Qiu
Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, People’s Republic of China
Yinjie Wang
Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, People’s Republic of China
Li Sun
Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, People’s Republic of China
Zhenni Wei
Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, People’s Republic of China
Yanyin Li
Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, People’s Republic of China
Jianjun Zheng
Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, People’s Republic of China
Yinhua Jin
Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, People’s Republic of China
Yong Li
Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, People’s Republic of China
Shiyu Du
Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, People’s Republic of China
Juan Li
Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, People’s Republic of China
Aiguo Wu
Cixi Institute of Biomedical Engineering, CAS Key Laboratory of Magnetic Materials and Devices & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, People’s Republic of China

Corresponding Author: Aiguo Wu

aiguo@nimte.ac.cn

Nano-Micro Letters, Vol. 11 (2019), Article Number: 61

Abstract

Zeolitic imidazolate frameworks (ZIFs) as smart drug delivery systems with microenvironment-triggered release have attracted much attention for tumor therapy. However, the exploration of ZIFs in biomedicine still encounters many issues, such as inconvenient surface modification, fast drug release during blood circulation, undesired damage to major organs, and severe in vivo toxicity. To address the above issues, we developed an Mn-ZIF-90 nanosystem functionalized with an originally designed active-targeting and pH-responsive magnetic resonance imaging (MRI) Y1 receptor ligand [Asn28, Pro30, Trp32]-NPY (25–36) for imaging-guided tumor therapy. After Y1 receptor ligand modification, the Mn-ZIF-90 nanosystem exhibited high drug loading, better blood circulation stability, and dual breast cancer cell membrane and mitochondria targetability, further favoring specific microenvironment-triggered tumor therapy. Meanwhile, this nanosystem showed promising T1-weighted magnetic resonance imaging contrast in vivo in the tumor sites. Especially, this nanosystem with fast clean-up had almost no obvious toxicity and no damage occurred to the major organs in mice. Therefore, this nanosystem shows potential for use in imaging-guided tumor therapy.


Highlights:


1 Manganese-zeolitic imidazolate frameworks (Mn-ZIF-90) with both high drug loading and magnetic resonance imaging (MRI) in vitro and in vivo were prepared.
2 The modification of a newly designed pH-protective and active-targeting Y1 receptor ligand reduces the drug release during blood circulation and specifically targets the tumor sites, improving therapeutic efficacy in vivo.
3 The combination of nano-size Mn-ZIF-90 and the highly specific Y1 receptor ligand promotes the specific drug accumulation in tumor sites.

Keywords

Zeolitic imidazolate frameworks-90 Drug delivery Magnetic resonance imaging pH-responsive release Y1 receptor ligand
Jiang, Zhenqi, Bo Yuan, Nianxiang Qiu, Yinjie Wang, Li Sun, Zhenni Wei, Yanyin Li, Jianjun Zheng, Yinhua Jin, Yong Li, Shiyu Du, Juan Li, and Aiguo Wu. 2019. “Manganese-Zeolitic Imidazolate Frameworks-90 With High Blood Circulation Stability for MRI-Guided Tumor Therapy”. Nano-Micro Letters 11 (July):61. https://doi.org/10.1007/s40820-019-0292-y.
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