Issue

Vol. 16 (2024)

Microgels for Cell Delivery in Tissue Engineering and Regenerative Medicine

https://doi.org/10.1007/s40820-024-01421-5
Leyan Xuan
Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, People’s Republic of China
Yingying Hou
Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, People’s Republic of China
Lu Liang
Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, People’s Republic of China
Jialin Wu
Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, People’s Republic of China
Kai Fan
School of Automation, Hangzhou Dianzi University, Hangzhou 310018, People’s Republic of China
Liming Lian
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA
Jianhua Qiu
Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, People’s Republic of China
Yingling Miao
Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, People’s Republic of China
Hossein Ravanbakhsh
Department of Biomedical Engineering, The University of Akron, Akron, OH 44325, USA
Mingen Xu
School of Automation, Hangzhou Dianzi University, Hangzhou 310018, People’s Republic of China
Guosheng Tang
Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, the NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou 511436, People’s Republic of China

Corresponding Author: Guosheng Tang

guoshengtang@gzhmu.edu.cn

Nano-Micro Letters, Vol. 16 (2024), Article Number: 218

Abstract

Microgels prepared from natural or synthetic hydrogel materials have aroused extensive attention as multifunctional cells or drug carriers, that are promising for tissue engineering and regenerative medicine. Microgels can also be aggregated into microporous scaffolds, promoting cell infiltration and proliferation for tissue repair. This review gives an overview of recent developments in the fabrication techniques and applications of microgels. A series of conventional and novel strategies including emulsification, microfluidic, lithography, electrospray, centrifugation, gas-shearing, three-dimensional bioprinting, etc. are discussed in depth. The characteristics and applications of microgels and microgel-based scaffolds for cell culture and delivery are elaborated with an emphasis on the advantages of these carriers in cell therapy. Additionally, we expound on the ongoing and foreseeable applications and current limitations of microgels and their aggregate in the field of biomedical engineering. Through stimulating innovative ideas, the present review paves new avenues for expanding the application of microgels in cell delivery techniques.


Highlights:
1 This review provides a comprehensive summary associated with recent progress in the preparation and application of microgels.
2 The characteristics and applications of microgels and microgel-based scaffolds for cell culture and delivery are elaborated with an emphasis on the advantages of these carriers in cell therapy.
3 This review expounds on the ongoing and foreseeable applications and current limitations of microgels and their aggregate in the field of biomedical engineering.
4 Through stimulating innovative ideas, the present review paves new avenues for expanding the application of microgels in cell delivery techniques.

Keywords

Microgels Cell delivery Scaffolds 3D bioprinting Single-cell microgels
Xuan, Leyan, Yingying Hou, Lu Liang, Jialin Wu, Kai Fan, Liming Lian, Jianhua Qiu, Yingling Miao, Hossein Ravanbakhsh, Mingen Xu, and Guosheng Tang. 2024. “Microgels for Cell Delivery in Tissue Engineering and Regenerative Medicine”. Nano-Micro Letters 16 (June):218. https://doi.org/10.1007/s40820-024-01421-5.
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