Issue

Vol. 11 (2019)

Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications

https://doi.org/10.1007/s40820-019-0330-9
Yao Liu
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, People’s Republic of China
Jingshan Luo
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, People’s Republic of China
Xiaojia Chen
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, People’s Republic of China
Wei Liu
Key Laboratory of Artificial Micro‑ and Nano‑Structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, People’s Republic of China
Tongkai Chen
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, People’s Republic of China

Corresponding Author: Tongkai Chen

chentongkai@gzucm.edu.cn

Nano-Micro Letters, Vol. 11 (2019), Article Number: 100

Abstract

Cell membrane coating technology is an approach to the biomimetic replication of cell membrane properties, and is an active area of ongoing research readily applicable to nanoscale biomedicine. Nanoparticles (NPs) coated with cell membranes offer an opportunity to unite natural cell membrane properties with those of the artificial inner core material. The coated NPs not only increase their biocompatibility but also achieve effective and extended circulation in vivo, allowing for the execution of targeted functions. Although cell membrane-coated NPs offer clear advantages, much work remains before they can be applied in clinical practice. In this review, we first provide a comprehensive overview of the theory of cell membrane coating technology, followed by a summary of the existing preparation and characterization techniques. Next, we focus on the functions and applications of various cell membrane types. In addition, we collate model drugs used in cell membrane coating technology, and review the patent applications related to this technology from the past 10 years. Finally, we survey future challenges and trends pertaining to this technology in an effort to provide a comprehensive overview of the future development of cell membrane coating technology.


Highlights:


1 The recent progress on using cell membrane-coated nanoparticles for drug delivery, cancer treatment, vascular disease, immune modulation, and detoxification are summarized in this review.
2 The patent applications related to the cell membrane coating technology from the past 10 years are collected, the future challenges and trends pertaining to this technology are comprehensively discussed.
3 Unique properties of cell membrane-coated nanoparticles make it a promising strategy for biomedical applications and will make outstanding contributions to human health.

Keywords

Cell membrane Biomimetic nanoparticles Cancer therapy Immune modulation Detoxification
Liu, Yao, Jingshan Luo, Xiaojia Chen, Wei Liu, and Tongkai Chen. 2019. “Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications”. Nano-Micro Letters 11 (November):100. https://doi.org/10.1007/s40820-019-0330-9.
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. S.S. Agasti, S. Rana, M.H. Park, C.K. Kim, C.C. You, V.M. Rotello, Nanoparticles for detection and diagnosis. Adv. Drug Deliv. Rev. 62(3), 316–328 (2010). https://doi.org/10.1016/j.addr.2009.11.004
  2. R.H. Fang, L. Zhang, Nanoparticle-based modulation of the immune system. Annu. Rev. Chem. Biomol. Eng. 7, 305–326 (2016). https://doi.org/10.1146/annurev-chembioeng-080615-034446
  3. S. Naahidi, M. Jafari, F. Edalat, K. Raymond, A. Khademhosseini, P. Chen, Biocompatibility of engineered nanoparticles for drug delivery. J. Control Release 166(2), 182–194 (2013). https://doi.org/10.1016/j.jconrel.2012.12.013
  4. T. Doane, C. Burda, Nanoparticle mediated non-covalent drug delivery. Adv. Drug Deliv. Rev. 65(5), 607–621 (2013). https://doi.org/10.1016/j.addr.2012.05.012
  5. S. Shi, F. Chen, S. Goel, S.A. Graves, H. Luo, C.P. Theuer, J.W. Engle, W. Cai, In vivo tumor-targeted dual-modality pet/optical imaging with a yolk/shell-structured silica nanosystem. Nano-Micro Lett. 10(4), 65 (2018). https://doi.org/10.1007/s40820-018-0216-2
  6. S. Shrivastava, D. Dash, Label-free colorimetric estimation of proteins using nanoparticles of silver. Nano-Micro Lett. 2(3), 164–168 (2010). https://doi.org/10.5101/nml.v2i3.p164-168
  7. M.E. Peralta, S.A. Jadhav, G. Magnacca, D. Scalarone, D.O. Martire, M.E. Parolo, L. Carlos, Synthesis and in vitro testing of thermoresponsive polymer-grafted core-shell magnetic mesoporous silica nanoparticles for efficient controlled and targeted drug delivery. J. Colloid Interf. Sci. 544, 198–205 (2019). https://doi.org/10.1016/j.jcis.2019.02.086
  8. J.Q. Peng, S. Fumoto, T. Suga, H. Miyamoto, N. Kuroda, S. Kawakami, K. Nishida, Targeted co-delivery of protein and drug to a tumor in vivo by sophisticated RGD-modified lipid-calcium carbonate nanoparticles. J. Control Release 302, 42–53 (2019). https://doi.org/10.1016/j.jconrel.2019.03.021
  9. P. Davoodi, L.Y. Lee, Q. Xu, V. Sunil, Y. Sun, S. Soh, C.H. Wang, Drug delivery systems for programmed and on-demand release. Adv. Drug Deliv. Rev. 132, 104–138 (2018). https://doi.org/10.1016/j.addr.2018.07.002
  10. A.C. Anselmo, S. Mitragotri, Cell-mediated delivery of nanoparticles: taking advantage of circulatory cells to target nanoparticles. J. Control Release 190, 531–541 (2014). https://doi.org/10.1016/j.jconrel.2014.03.050
  11. A. Parodi, R. Molinaro, M. Sushnitha, M. Evangelopoulos, J.O. Martinez, N. Arrighetti, C. Corbo, E. Tasciotti, Bio-inspired engineering of cell- and virus-like nanoparticles for drug delivery. Biomaterials 147, 155–168 (2017). https://doi.org/10.1016/j.biomaterials.2017.09.020
  12. J.L. Wang, X.J. Du, J.X. Yang, S. Shen, H.J. Li et al., The effect of surface poly(ethylene glycol) length on in vivo drug delivery behaviors of polymeric nanoparticles. Biomaterials 182, 104–113 (2018). https://doi.org/10.1016/j.biomaterials.2018.08.022
  13. F.M. Veronese, G. Pasut, Pegylation, successful approach to drug delivery. Drug Discov. Today 10(21), 1451–1458 (2005). https://doi.org/10.1016/s1359-6446(05)03575-0
  14. T. Shimizu, A.S. Abu Lila, R. Fujita, M. Awata, M. Kawanishi, Y. Hashimoto, K. Okuhira, Y. Ishima, T. Ishida, A hydroxyl peg version of pegylated liposomes and its impact on anti-PEG IGm induction and on the accelerated clearance of pegylated liposomes. Eur. J. Pharm. Biopharm. 127, 142–149 (2018). https://doi.org/10.1016/j.ejpb.2018.02.019
  15. K. Shiraishi, M. Hamano, H. Ma, K. Kawano, Y. Maitani, T. Aoshi, K.J. Ishii, M. Yokoyama, Hydrophobic blocks of PEG-conjugates play a significant role in the accelerated blood clearance (ABC) phenomenon. J. Control Release 165(3), 183–190 (2013). https://doi.org/10.1016/j.jconrel.2012.11.016
  16. X. Wan, J. Zhang, W. Yu, L. Shen, S. Ji, T. Hu, Effect of protein immunogenicity and peg size and branching on the anti-PEG immune response to pegylated proteins. Process Biochem. 52, 183–191 (2017). https://doi.org/10.1016/j.procbio.2016.09.029
  17. M.Y. Thanuja, C. Anupama, S.H. Ranganath, Bioengineered cellular and cell membrane-derived vehicles for actively targeted drug delivery: so near and yet so far. Adv. Drug Deliv. Rev. 132, 57–80 (2018). https://doi.org/10.1016/j.addr.2018.06.012
  18. C. Sabu, C. Rejo, S. Kotta, K. Pramod, Bioinspired and biomimetic systems for advanced drug and gene delivery. J. Control Release 287, 142–155 (2018). https://doi.org/10.1016/j.jconrel.2018.08.033
  19. R.A. Meyer, J.C. Sunshine, J.J. Green, Biomimetic particles as therapeutics. Trends Biotechnol. 33(9), 514–524 (2015). https://doi.org/10.1016/j.tibtech.2015.07.001
  20. R.H. Fang, Y. Jiang, J.C. Fang, L. Zhang, Cell membrane-derived nanomaterials for biomedical applications. Biomaterials 128, 69–83 (2017). https://doi.org/10.1016/j.biomaterials.2017.02.041
  21. R.H. Fang, A.V. Kroll, W. Gao, L. Zhang, Cell membrane coating nanotechnology. Adv. Mater. 30(23), e1706759 (2018). https://doi.org/10.1002/adma.201706759
  22. Q. Xia, Y. Zhang, Z. Li, X. Hou, N. Feng, Red blood cell membrane-camouflaged nanoparticles: a novel drug delivery system for antitumor application. Acta Pharmaceutica Sinica B 9(4), 675–689 (2019). https://doi.org/10.1016/j.apsb.2019.01.011
  23. H.H. Wu, Y. Zhou, Y. Tabata, J.Q. Gao, Mesenchymal stem cell-based drug delivery strategy: from cells to biomimetic. J. Control Release 294, 102–113 (2019). https://doi.org/10.1016/j.jconrel.2018.12.019
  24. C.M. Hu, L. Zhang, S. Aryal, C. Cheung, R.H. Fang, L. Zhang, Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform. Proc. Natl. Acad. Sci. U.S.A. 108(27), 10980–10985 (2011). https://doi.org/10.1073/pnas.1106634108
  25. A.V. Kroll, R.H. Fang, L. Zhang, Biointerfacing and applications of cell membrane-coated nanoparticles. Bioconjug. Chem. 28(1), 23–32 (2017). https://doi.org/10.1021/acs.bioconjchem.6b00569
  26. K. Simons, W.L. Vaz, Model systems, lipid rafts, and cell membranes. Annu. Rev. Biophys. Biomol. Struct. 33, 269–295 (2004). https://doi.org/10.1146/annurev.biophys.32.110601.141803
  27. Y. Zhai, J. Su, W. Ran, P. Zhang, Q. Yin, Z. Zhang, H. Yu, Y. Li, Preparation and application of cell membrane-camouflaged nanoparticles for cancer therapy. Theranostics 7(10), 2575–2592 (2017). https://doi.org/10.7150/thno.20118
  28. X. Wei, J. Gao, R.H. Fang, B.T. Luk, A.V. Kroll et al., Nanoparticles camouflaged in platelet membrane coating as an antibody decoy for the treatment of immune thrombocytopenia. Biomaterials 111, 116–123 (2016). https://doi.org/10.1016/j.biomaterials.2016.10.003
  29. L. Rao, L.-L. Bu, J.-H. Xu, B. Cai, G.-T. Yu et al., Red blood cell membrane as a biomimetic nanocoating for prolonged circulation time and reduced accelerated blood clearance. Small 11(46), 6225–6236 (2015). https://doi.org/10.1002/smll.201502388
  30. T. Kang, Q. Zhu, D. Wei, J. Feng, J. Yao et al., Nanoparticles coated with neutrophil membranes can effectively treat cancer metastasis. ACS Nano 11(2), 1397–1411 (2017). https://doi.org/10.1021/acsnano.6b06477
  31. C. Gao, Z. Lin, Z. Wu, X. Lin, Q. He, Stem-cell-membrane camouflaging on near-infrared photoactivated upconversion nanoarchitectures for in vivo remote-controlled photodynamic therapy. ACS Appl. Mater. Interfaces. 8(50), 34252–34260 (2016). https://doi.org/10.1021/acsami.6b12865
  32. H. Cao, Z. Dan, X. He, Z. Zhang, H. Yu, Q. Yin, Y. Li, Liposomes coated with isolated macrophage membrane can target lung metastasis of breast cancer. ACS Nano 10(8), 7738–7748 (2016). https://doi.org/10.1021/acsnano.6b03148
  33. R. Yang, J. Xu, L. Xu, X. Sun, Q. Chen, Y. Zhao, R. Peng, Z. Liu, Cancer cell membrane-coated adjuvant nanoparticles with mannose modification for effective anticancer vaccination. ACS Nano 12(6), 5121–5129 (2018). https://doi.org/10.1021/acsnano.7b09041
  34. L. Rao, Z. He, Q.F. Meng, Z. Zhou, L.L. Bu et al., Effective cancer targeting and imaging using macrophage membrane-camouflaged upconversion nanoparticles. J. Biomed. Mater. Res. A 105(2), 521–530 (2017). https://doi.org/10.1002/jbm.a.35927
  35. V. Vijayan, S. Uthaman, I.K. Park, in Cell membrane coated nanoparticles: an emerging biomimetic nanoplatform for targeted bioimaging and therapy, ed. by NOH I (Springer, Singapore Pte Ltd, Singapore, 2018), pp. 45–59
  36. Z. Fan, P.Y. Li, J. Deng, S.C. Bady, H. Cheng, Cell membrane coating for reducing nanoparticle-induced inflammatory responses to scaffold constructs. Nano Res. 11(10), 5573–5583 (2018). https://doi.org/10.1007/s12274-018-2084-y
  37. A. Parodi, N. Quattrocchi, A.L. van de Ven, C. Chiappini, M. Evangelopoulos et al., Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions. Nat. Nanotechnol. 8(1), 61–68 (2013). https://doi.org/10.1038/nnano.2012.212
  38. L. Rao, Q.-F. Meng, Q. Huang, P. Liu, L.-L. Bu et al., Photocatalytic degradation of cell membrane coatings for controlled drug release. Adv. Healthc. Mater. 5(12), 1420–1427 (2016). https://doi.org/10.1002/adhm.201600303
  39. J. Su, H. Sun, Q. Meng, P. Zhang, Q. Yin, Y. Li, Enhanced blood suspensibility and laser-activated tumor-specific drug release of theranostic mesoporous silica nanoparticles by functionalizing with erythrocyte membranes. Theranostics 7(3), 523–537 (2017). https://doi.org/10.7150/thno.17259
  40. Q. Xu, J. Wan, N. Bie, X. Song, X. Yang et al., A biomimetic gold nanocages-based nanoplatform for efficient tumor ablation and reduced inflammation. Theranostics 8(19), 5362–5378 (2018). https://doi.org/10.7150/thno.27631
  41. X. Ren, R. Zheng, X. Fang, X. Wang, X. Zhang, W. Yang, X. Sha, Red blood cell membrane camouflaged magnetic nanoclusters for imaging-guided photothermal therapy. Biomaterials 92, 13–24 (2016). https://doi.org/10.1016/j.biomaterials.2016.03.026
  42. L. Rao, Q.F. Meng, L.L. Bu, B. Cai, Q. Huang et al., Erythrocyte membrane-coated upconversion nanoparticles with minimal protein adsorption for enhanced tumor imaging. ACS Appl. Mater. Interfaces 9(3), 2159–2168 (2017). https://doi.org/10.1021/acsami.6b14450
  43. W.L. Liu, M.Z. Zou, T. Liu, J.Y. Zeng, X. Li et al., Expandable immunotherapeutic nanoplatforms engineered from cytomembranes of hybrid cells derived from cancer and dendritic cells. Adv. Mater. 31(18), 1900499 (2019). https://doi.org/10.1002/adma.201900499
  44. Z. Fan, J. Deng, P.Y. Li, D.R. Chery, Y. Su et al., A new class of biological materials: cell membrane-derived hydrogel scaffolds. Biomaterials 197, 244–254 (2019). https://doi.org/10.1016/j.biomaterials.2019.01.020
  45. X. Liang, X. Ye, C. Wang, C. Xing, Q. Miao et al., Photothermal cancer immunotherapy by erythrocyte membrane-coated black phosphorus formulation. J. Control Release 296, 150–161 (2019). https://doi.org/10.1016/j.jconrel.2019.01.027
  46. D. Dehaini, X. Wei, R.H. Fang, S. Masson, P. Angsantikul et al., Erythrocyte-platelet hybrid membrane coating for enhanced nanoparticle functionalization. Adv. Mater. 29(16), 1606209 (2017). https://doi.org/10.1002/adma.201606209
  47. M. Mathiyazhakan, C. Wiraja, C. Xu, A concise review of gold nanoparticles-based photo-responsive liposomes for controlled drug delivery. Nano-Micro Lett. 10(1), 10 (2018). https://doi.org/10.1007/s40820-017-0166-0
  48. V. Vijayan, S. Uthaman, I.K. Park, Cell membrane coated nanoparticles: an emerging biomimetic nanoplatform for targeted bioimaging and therapy. Adv. Exp. Med. Biol. 1064, 45–59 (2018). https://doi.org/10.1007/978-981-13-0445-3_3
  49. S.Y. Li, H. Cheng, W.X. Qiu, L. Zhang, S.S. Wan, J.Y. Zeng, X.Z. Zhang, Cancer cell membrane-coated biomimetic platform for tumor targeted photodynamic therapy and hypoxia-amplified bioreductive therapy. Biomaterials 142, 149–161 (2017). https://doi.org/10.1016/j.biomaterials.2017.07.026
  50. C. Gao, Z. Lin, B. Jurado-Sanchez, X. Lin, Z. Wu, Q. He, Stem cell membrane-coated nanogels for highly efficient in vivo tumor targeted drug delivery. Small 12(30), 4056–4062 (2016). https://doi.org/10.1002/smll.201600624
  51. W. Chen, J. Ouyang, X. Yi, Y. Xu, C. Niu et al., Black phosphorus nanosheets as a neuroprotective nanomedicine for neurodegenerative disorder therapy. Adv. Mater. 30(3), 1703458 (2018). https://doi.org/10.1002/adma.201703458
  52. Y. Chen, M. Chen, Y. Zhang, J.H. Lee, T. Escajadillo et al., Broad-spectrum neutralization of pore-forming toxins with human erythrocyte membrane-coated nanosponges. Adv. Healthc. Mater. 7(13), e1701366 (2018). https://doi.org/10.1002/adhm.201701366
  53. H.W. Chen, Z.S. Fang, Y.T. Chen, Y.I. Chen, B.Y. Yao et al., Targeting and enrichment of viral pathogen by cell membrane cloaked magnetic nanoparticles for enhanced detection. ACS Appl. Mater. Interfaces 9(46), 39953–39961 (2017). https://doi.org/10.1021/acsami.7b09931
  54. X. Wei, G. Zhang, D. Ran, N. Krishnan, R.H. Fang, W. Gao, S.A. Spector, L. Zhang, T-cell-mimicking nanoparticles can neutralize HIV infectivity. Adv. Mater. 30(45), e1802233 (2018). https://doi.org/10.1002/adma.201802233
  55. S. Thamphiwatana, P. Angsantikul, T. Escajadillo, Q. Zhang, J. Olson et al., Macrophage-like nanoparticles concurrently absorbing endotoxins and proinflammatory cytokines for sepsis management. Proc. Natl. Acad. Sci. U.S.A. 114(43), 11488–11493 (2017). https://doi.org/10.1073/pnas.1714267114
  56. Y. Han, H. Pan, W. Li, Z. Chen, A. Ma et al., T cell membrane mimicking nanoparticles with bioorthogonal targeting and immune recognition for enhanced photothermal therapy. Adv. Sci. 6(15), 1900251 (2019). https://doi.org/10.1002/advs.201900251
  57. J. Jin, B. Krishnamachary, J.D. Barnett, S. Chatterjee, D. Chang et al., Human cancer cell membrane-coated biomimetic nanoparticles reduce fibroblast-mediated invasion and metastasis and induce t-cells. ACS Appl. Mater. Interfaces 11(8), 7850–7861 (2019). https://doi.org/10.1021/acsami.8b22309
  58. F. Gao, L. Xu, B. Yang, F. Fan, L. Yang, Kill the real with the fake: eliminate intracellular Staphylococcus aureus using nanoparticle coated with its extracellular vesicle membrane as active-targeting drug carrier. ACS Infect. Dis. 5(2), 218–227 (2019). https://doi.org/10.1021/acsinfecdis.8b00212
  59. J. Xie, Q. Shen, K. Huang, T. Zheng, L. Cheng et al., Oriented assembly of cell-mimicking nanoparticles via a molecular affinity strategy for targeted drug delivery. ACS Nano 13(5), 5268–5277 (2019). https://doi.org/10.1021/acsnano.8b09681
  60. J.M. Liu, D.D. Zhang, G.Z. Fang, S. Wang, Erythrocyte membrane bioinspired near-infrared persistent luminescence nanocarriers for in vivo long-circulating bioimaging and drug delivery. Biomaterials 165, 39–47 (2018). https://doi.org/10.1016/j.biomaterials.2018.02.042
  61. J. Zhang, Y. Miao, W. Ni, H. Xiao, J. Zhang, Cancer cell membrane coated silica nanoparticles loaded with ICG for tumour specific photothermal therapy of osteosarcoma. Artif. Cells Nanomed. Biotechnol. 47(1), 2298–2305 (2019). https://doi.org/10.1080/21691401.2019.1622554
  62. J. Yang, Y. Teng, Y. Fu, C. Zhang, Chlorins e6 loaded silica nanoparticles coated with gastric cancer cell membrane for tumor specific photodynamic therapy of gastric cancer. Int. J. Nanomed. 14, 5061–5071 (2019). https://doi.org/10.2147/IJN.S202910
  63. H. Ding, Y. Lv, D. Ni, J. Wang, Z. Tian, W. Wei, G. Ma, Erythrocyte membrane-coated NIR-triggered biomimetic nanovectors with programmed delivery for photodynamic therapy of cancer. Nanoscale 7(21), 9806–9815 (2015). https://doi.org/10.1039/c5nr02470f
  64. L. Rao, L.-L. Bu, B. Cai, J.-H. Xu, A. Li et al., Cancer cell membrane-coated upconversion nanoprobes for highly specific tumor imaging. Adv. Mater. 28(18), 3460–3466 (2016). https://doi.org/10.1002/adma.201506086
  65. J.-G. Piao, L. Wang, F. Gao, Y.-Z. You, Y. Xiong, L. Yang, Erythrocyte membrane is an alternative coating to polyethylene glycol for prolonging the circulation lifetime of gold nanocages for photothermal therapy. ACS Nano 8(10), 10414–10425 (2014). https://doi.org/10.1021/nn503779d
  66. W. Gao, C.M. Hu, R.H. Fang, B.T. Luk, J. Su, L. Zhang, Surface functionalization of gold nanoparticles with red blood cell membranes. Adv. Mater. 25(26), 3549–3553 (2013). https://doi.org/10.1002/adma.201300638
  67. L. Rao, L.L. Bu, L. Ma, W. Wang, H. Liu et al., Platelet-facilitated photothermal therapy of head and neck squamous cell carcinoma. Angew. Chem. Int. Ed. 57(4), 986–991 (2018). https://doi.org/10.1002/anie.201709457
  68. W. Gao, R.H. Fang, S. Thamphiwatana, B.T. Luk, J. Li et al., Modulating antibacterial immunity via bacterial membrane-coated nanoparticles. Nano Lett. 15(2), 1403–1409 (2015). https://doi.org/10.1021/nl504798g
  69. J. Zhu, M. Zhang, D. Zheng, S. Hong, J. Feng, X.Z. Zhang, A universal approach to render nanomedicine with biological identity derived from cell membranes. Biomacromol 19(6), 2043–2052 (2018). https://doi.org/10.1021/acs.biomac.8b00242
  70. G.T. Yu, L. Rao, H. Wu, L.L. Yang, L.L. Bu et al., Myeloid-derived suppressor cell membrane-coated magnetic nanoparticles for cancer theranostics by inducing macrophage polarization and synergizing immunogenic cell death. Adv. Funct. Mater. 28(37), 1801389 (2018). https://doi.org/10.1002/adfm.201801389
  71. L. Rao, L.L. Bu, J.H. Xu, B. Cai, G.T. Yu et al., Red blood cell membrane as a biomimetic nanocoating for prolonged circulation time and reduced accelerated blood clearance. Small 11(46), 6225–6236 (2015). https://doi.org/10.1002/smll.201502388
  72. L. Rao, J.H. Xu, B. Cai, H. Liu, M. Li et al., Synthetic nanoparticles camouflaged with biomimetic erythrocyte membranes for reduced reticuloendothelial system uptake. Nanotechnology 27(8), 085106 (2016). https://doi.org/10.1088/0957-4484/27/8/085106
  73. Y. Zhai, W. Ran, J. Su, T. Lang, J. Meng, G. Wang, P. Zhang, Y. Li, Traceable bioinspired nanoparticle for the treatment of metastatic breast cancer via NIR-trigged intracellular delivery of methylene blue and cisplatin. Adv. Mater. 30(34), 1802378 (2018). https://doi.org/10.1002/adma.201802378
  74. Y. Zhang, J. Zhang, W. Chen, P. Angsantikul, K.A. Spiekermann, R.H. Fang, W. Gao, L. Zhang, Erythrocyte membrane-coated nanogel for combinatorial antivirulence and responsive antimicrobial delivery against Staphylococcus aureus infection. J. Control Release 263, 185–191 (2017). https://doi.org/10.1016/j.jconrel.2017.01.016
  75. W. Liu, M. Ruan, Y. Wang, R. Song, X. Ji, J. Xu, J. Dai, W. Xue, Light-triggered biomimetic nanoerythrocyte for tumor-targeted lung metastatic combination therapy of malignant melanoma. Small 14(38), 1801754 (2018). https://doi.org/10.1002/smll.201801754
  76. J. Zhuang, M. Ying, K. Spiekermann, M. Holay, Y. Zhang et al., Biomimetic nanoemulsions for oxygen delivery in vivo. Adv. Mater. 30(49), 1804693 (2018). https://doi.org/10.1002/adma.201804693
  77. H. Ren, J. Liu, Y. Li, H. Wang, S. Ge, A. Yuan, Y. Hu, J. Wu, Oxygen self-enriched nanoparticles functionalized with erythrocyte membranes for long circulation and enhanced phototherapy. Acta Biomater. 59, 269–282 (2017). https://doi.org/10.1016/j.actbio.2017.06.035
  78. Z. Chai, D. Ran, L. Lu, C. Zhan, H. Ruan et al., Ligand-modified cell membrane enables the targeted delivery of drug nanocrystals to glioma. ACS Nano 13(5), 5591–5601 (2019). https://doi.org/10.1021/acsnano.9b00661
  79. T. Liu, C. Shi, L. Duan, Z. Zhang, L. Luo, S. Goel, W. Cai, T. Chen, A highly hemocompatible erythrocyte membrane-coated ultrasmall selenium nanosystem for simultaneous cancer radiosensitization and precise antiangiogenesis. J. Mater. Chem. B 6(29), 4756–4764 (2018). https://doi.org/10.1039/c8tb01398e
  80. W. He, J. Frueh, Z. Wu, Q. He, Leucocyte membrane-coated Janus microcapsules for enhanced photothermal cancer treatment. Langmuir 32(15), 3637–3644 (2016). https://doi.org/10.1021/acs.langmuir.5b04762
  81. L. Rao, B. Cai, L.-L. Bu, Q.-Q. Liao, S.-S. Guo, X.-Z. Zhao, W.-F. Dong, W. Liu, Microfluidic electroporation-facilitated synthesis of erythrocyte membrane-coated magnetic nanoparticles for enhanced imaging-guided cancer therapy. ACS Nano 11(4), 3496–3505 (2017). https://doi.org/10.1021/acsnano.7b00133
  82. J. Li, Y. Ai, L. Wang, P. Bu, C.C. Sharkey et al., Targeted drug delivery to circulating tumor cells via platelet membrane-functionalized particles. Biomaterials 76, 52–65 (2016). https://doi.org/10.1016/j.biomaterials.2015.10.046
  83. Y. Wang, K. Zhang, X. Qin, T. Li, J. Qiu et al., Biomimetic nanotherapies: red blood cell based core–shell structured nanocomplexes for atherosclerosis management. Adv. Sci. 6(12), 1900172 (2019). https://doi.org/10.1002/advs.201900172
  84. H. Chen, H. Sha, L. Zhang, H. Qian, F. Chen et al., Lipid insertion enables targeted functionalization of paclitaxel-loaded erythrocyte membrane nanosystem by tumor-penetrating bispecific recombinant protein. Int. J. Nanomed. 13, 5347–5359 (2018). https://doi.org/10.2147/IJN.S165109
  85. X. Han, C. Wang, Z. Liu, Red blood cells as smart delivery systems. Bioconjug. Chem. 29(4), 852–860 (2018). https://doi.org/10.1021/acs.bioconjchem.7b00758
  86. H. Zhang, Erythrocytes in nanomedicine: an optimal blend of natural and synthetic materials. Biomater. Sci. 4(7), 1024–1031 (2016). https://doi.org/10.1039/c6bm00072j
  87. Z. Zhang, H. Qian, J. Huang, H. Sha, H. Zhang et al., Anti-EGFR-iRGD recombinant protein modified biomimetic nanoparticles loaded with gambogic acid to enhance targeting and antitumor ability in colorectal cancer treatment. Int. J. Nanomed. 13, 4961–4975 (2018). https://doi.org/10.2147/IJN.S170148
  88. S. Fu, M. Liang, Y. Wang, L. Cui, C. Gao et al., Dual-modified novel biomimetic nanocarriers improve targeting and therapeutic efficacy in glioma. ACS Appl. Mater. Interfaces 11(2), 1841–1854 (2019). https://doi.org/10.1021/acsami.8b18664
  89. Z. Zhang, H. Qian, M. Yang, R. Li, J. Hu et al., Gambogic acid-loaded biomimetic nanoparticles in colorectal cancer treatment. Int. J. Nanomed. 12, 1593–1605 (2017). https://doi.org/10.2147/IJN.S127256
  90. Q. Fu, P. Lv, Z. Chen, D. Ni, L. Zhang et al., Programmed co-delivery of paclitaxel and doxorubicin boosted by camouflaging with erythrocyte membrane. Nanoscale 7(9), 4020–4030 (2015). https://doi.org/10.1039/c4nr07027e
  91. X. Zhang, P. Angsantikul, M. Ying, J. Zhuang, Q. Zhang et al., Remote loading of small-molecule therapeutics into cholesterol-enriched cell-membrane-derived vesicles. Angew. Chem. Int. Ed. 56(45), 14075–14079 (2017). https://doi.org/10.1002/anie.201707598
  92. Z. Chai, X. Hu, X. Wei, C. Zhan, L. Lu et al., A facile approach to functionalizing cell membrane-coated nanoparticles with neurotoxin-derived peptide for brain-targeted drug delivery. J. Control Release 264, 102–111 (2017). https://doi.org/10.1016/j.jconrel.2017.08.027
  93. C. Wang, Y. Ye, W. Sun, J. Yu, J. Wang et al., Red blood cells for glucose-responsive insulin delivery. Adv. Mater. 29(18), 1606617 (2017). https://doi.org/10.1002/adma.201606617
  94. P. Xue, R. Yang, L. Sun, Q. Li, L. Zhang, Z. Xu, Y. Kang, Indocyanine green-conjugated magnetic prussian blue nanoparticles for synchronous photothermal/photodynamic tumor therapy. Nano-Micro Lett. 10(4), 74 (2018). https://doi.org/10.1007/s40820-018-0227-z
  95. Q. Pei, X. Hu, X. Zheng, S. Liu, Y. Li, X. Jing, Z. Xie, Light-activatable red blood cell membrane-camouflaged dimeric prodrug nanoparticles for synergistic photodynamic/chemotherapy. ACS Nano 12(2), 1630–1641 (2018). https://doi.org/10.1021/acsnano.7b08219
  96. M. Xuan, J. Shao, J. Zhao, Q. Li, L. Dai, J. Li, Magnetic mesoporous silica nanoparticles cloaked by red blood cell membranes: applications in cancer therapy. Angew. Chem. Int. Ed. 57(21), 6049–6053 (2018). https://doi.org/10.1002/anie.201712996
  97. L. Rao, B. Cai, L.L. Bu, Q.Q. Liao, S.S. Guo et al., Microfluidic electroporation-facilitated synthesis of erythrocyte membrane-coated magnetic nanoparticles for enhanced imaging-guided cancer therapy. ACS Nano 11(4), 3496–3505 (2017). https://doi.org/10.1021/acsnano.7b00133
  98. T. Jiang, B. Zhang, S. Shen, Y. Tuo, Z. Luo, Y. Hu, Z. Pang, X. Jiang, Tumor microenvironment modulation by cyclopamine improved photothermal therapy of biomimetic gold nanorods for pancreatic ductal adenocarcinomas. ACS Appl. Mater. Interfaces 9(37), 31497–31508 (2017). https://doi.org/10.1021/acsami.7b09458
  99. D.-M. Zhu, W. Xie, Y.-S. Xiao, M. Suo, M.-H. Zan et al., Erythrocyte membrane-coated gold nanocages for targeted photothermal and chemical cancer therapy. Nanotechnology 29(8), 084002 (2018). https://doi.org/10.1088/1361-6528/aa9ca1
  100. H. Ren, J. Liu, Y. Li, H. Wang, S. Ge, A. Yuan, Y. Hu, J. Wu, Oxygen self-enriched nanoparticles functionalized with erythrocyte membranes for long circulation and enhanced phototherapy. Acta Biomater. 59, 269–282 (2017). https://doi.org/10.1016/j.actbio.2017.06.035
  101. P.A. Gentry, The mammalian blood platelet: its role in haemostasis, inflammation and tissue repair. J. Comp. Pathol. 107(3), 243–270 (1992). https://doi.org/10.1016/0021-9975(92)90002-c
  102. Q. Hu, H.N. Bomba, Z. Gu, Engineering platelet-mimicking drug delivery vehicles. Front. Chem. Sci. Eng. 11(4), 624–632 (2017). https://doi.org/10.1007/s11705-017-1614-6
  103. J.N. Thon, J.E. Italiano, Platelets: production, morphology and ultrastructure. Handb. Exp. Pharmacol. 210, 3–22 (2012). https://doi.org/10.1007/978-3-642-29423-5_1
  104. Y. Lu, Q. Hu, C. Jiang, Z. Gu, Platelet for drug delivery. Curr. Opin. Biotechnol. 58, 81–91 (2019). https://doi.org/10.1016/j.copbio.2018.11.010
  105. S.M. Moghimi, A.C. Hunter, D. Peer, Platelet mimicry: the emperor’s new clothes? Nanomed. Nanotechnol. Biol. Med. 12(1), 245–248 (2016). https://doi.org/10.1016/j.nano.2015.09.005
  106. Q. Hu, W. Sun, C. Qian, C. Wang, H.N. Bomba, Z. Gu, Anticancer platelet-mimicking nanovehicles. Adv. Mater. 27(44), 7043–7050 (2015). https://doi.org/10.1002/adma.201503323
  107. T.G. Walsh, P. Metharom, M.C. Berndt, The functional role of platelets in the regulation of angiogenesis. Platelets 26(3), 199–211 (2015). https://doi.org/10.3109/09537104.2014.909022
  108. S.R. Hyslop, E.C. Josefsson, Undercover agents: targeting tumours with modified platelets. Trends Cancer 3(3), 235–246 (2017). https://doi.org/10.1016/j.trecan.2017.01.006
  109. L. Jing, H. Qu, D. Wu, C. Zhu, Y. Yang et al., Platelet-camouflaged nanococktail: simultaneous inhibition of drug-resistant tumor growth and metastasis via a cancer cells and tumor vasculature dual-targeting strategy. Theranostics 8(10), 2683–2695 (2018). https://doi.org/10.7150/thno.23654
  110. M. Ying, J. Zhuang, X. Wei, X. Zhang, Y. Zhang et al., Remote-loaded platelet vesicles for disease-targeted delivery of therapeutics. Adv. Funct. Mater. 28(22), 1801032 (2018). https://doi.org/10.1002/adfm.201801032
  111. C.M. Hu, R.H. Fang, K.C. Wang, B.T. Luk, S. Thamphiwatana et al., Nanoparticle biointerfacing by platelet membrane cloaking. Nature 526(7571), 118–121 (2015). https://doi.org/10.1038/nature15373
  112. B. Wang, G. Chen, G. Urabe, R. Xie, Y. Wang et al., A paradigm of endothelium-protective and stent-free anti-restenotic therapy using biomimetic nanoclusters. Biomaterials 178, 293–301 (2018). https://doi.org/10.1016/j.biomaterials.2018.06.025
  113. Y. Song, Z. Huang, X. Liu, Z. Pang, J. Chen et al., Platelet membrane-coated nanoparticle-mediated targeting delivery of rapamycin blocks atherosclerotic plaque development and stabilizes plaque in apolipoprotein E-deficient (apoE(−/−)) mice. Nanomedicine 15(1), 13–24 (2019). https://doi.org/10.1016/j.nano.2018.08.002
  114. L. Xu, F. Gao, F. Fan, L. Yang, Platelet membrane coating coupled with solar irradiation endows a photodynamic nanosystem with both improved antitumor efficacy and undetectable skin damage. Biomaterials 159, 59–67 (2018). https://doi.org/10.1016/j.biomaterials.2017.12.028
  115. L. Rao, L.-L. Bu, Q.-F. Meng, B. Cai, W.-W. Deng et al., Antitumor platelet-mimicking magnetic nanoparticles. Adv. Funct. Mater. 27(9), 1604774 (2017). https://doi.org/10.1002/adfm.201604774
  116. H. Zuo, J. Tao, H. Shi, J. He, Z. Zhou, C. Zhang, Platelet-mimicking nanoparticles co-loaded with W18O49 and metformin alleviate tumor hypoxia for enhanced photodynamic therapy and photothermal therapy. Acta Biomater. 80, 296–307 (2018). https://doi.org/10.1016/j.actbio.2018.09.017
  117. K. Jin, Z. Luo, B. Zhang, Z. Pang, Biomimetic nanoparticles for inflammation targeting. Acta Pharmaceutica Sinica B 8(1), 23–33 (2018). https://doi.org/10.1016/j.apsb.2017.12.002
  118. R. Li, Y. He, S. Zhang, J. Qin, J. Wang, Cell membrane-based nanoparticles: a new biomimetic platform for tumor diagnosis and treatment. Acta Pharmaceutica Sinica B 8(1), 14–22 (2018). https://doi.org/10.1016/j.apsb.2017.11.009
  119. J. Si, S. Shao, Y. Shen, K. Wang, Macrophages as active nanocarriers for targeted early and adjuvant cancer chemotherapy. Small 12(37), 5108–5119 (2016). https://doi.org/10.1002/smll.201601282
  120. W.J. Halliday, S. Miller, Leukocyte adherence inhibition: a simple test for cell-mediated tumour immunity and serum blocking factors. Int. J. Cancer 9(3), 477–483 (1972). https://doi.org/10.1002/ijc.2910090304
  121. A. Parodi, N. Quattrocchi, A.L. van de Ven, C. Chiappini, M. Evangelopoulos et al., Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions. Nat. Nanotechnol. 8(1), 61–68 (2013). https://doi.org/10.1038/nnano.2012.212
  122. W.J. Goh, C.K. Lee, S. Zou, E.C.Y. Woon, B. Czarny, G. Pastorin, Doxorubicin-loaded cell-derived nanovesicles: an alternative targeted approach for anti-tumor therapy. Int. J. Nanomed. 12, 2759–2767 (2017). https://doi.org/10.2147/ijn.s131786
  123. S. Krishnamurthy, M.K. Gnanasammandhan, C. Xie, K. Huang, M.Y. Cui, J.M. Chan, Monocyte cell membrane-derived nanoghosts for targeted cancer therapy. Nanoscale 8(13), 6981–6985 (2016). https://doi.org/10.1039/c5nr07588b
  124. L. Zhang, R. Li, H. Chen, J. Wei, H. Qian et al., Human cytotoxic T-lymphocyte membrane-camouflaged nanoparticles combined with low-dose irradiation: a new approach to enhance drug targeting in gastric cancer. Int. J. Nanomed. 12, 2129–2142 (2017). https://doi.org/10.2147/ijn.s126016
  125. A. Pitchaimani, N. Tuyen Duong Thanh, S. Aryal, Natural killer cell membrane infused biomimetic liposomes for targeted tumor therapy. Biomaterials 160, 124–137 (2018). https://doi.org/10.1016/j.biomaterials.2018.01.018
  126. Y. Zhang, K. Gai, C. Li, Q. Guo, Q. Chen et al., Macrophage-membrane-coated nanoparticles for tumor-targeted chemotherapy. Nano Lett. 18(3), 1908–1915 (2018). https://doi.org/10.1021/acs.nanolett.7b05263
  127. C. Ju, Y. Wen, L. Zhang, Q. Wang, L. Xue, J. Shen, C. Zhang, Neoadjuvant chemotherapy based on abraxane/human neutrophils cytopharmaceuticals with radiotherapy for gastric cancer. Small 15(5), 1804191 (2019). https://doi.org/10.1002/smll.201804191
  128. G. Deng, Z. Sun, S. Li, X. Peng, W. Li et al., Cell-membrane immunotherapy based on natural killer cell membrane coated nanoparticles for the effective inhibition of primary and abscopal tumor growth. ACS Nano 12(12), 12096–12108 (2018). https://doi.org/10.1021/acsnano.8b05292
  129. M. Xuan, J. Shao, L. Dai, J. Li, Q. He, Macrophage cell membrane camouflaged au nanoshells for in vivo prolonged circulation life and enhanced cancer photothermal therapy. ACS Appl. Mater. Interfaces 8(15), 9610–9618 (2016). https://doi.org/10.1021/acsami.6b00853
  130. Q.-F. Meng, L. Rao, M. Zan, M. Chen, G.-T. Yu et al., Macrophage membrane-coated iron oxide nanoparticles for enhanced photothermal tumor therapy. Nanotechnology 29(13), 134004 (2018). https://doi.org/10.1088/1361-6528/aaa7c7
  131. W. Lv, J. Xu, X. Wang, X. Li, Q. Xu, H. Xin, Bioengineered boronic ester modified dextran polymer nanoparticles as reactive oxygen species responsive nanocarrier for ischemic stroke treatment. ACS Nano 12(6), 5417–5426 (2018). https://doi.org/10.1021/acsnano.8b00477
  132. H. Zhao, L. Li, J. Zhang, C. Zheng, K. Ding, H. Xiao, L. Wang, Z. Zhang, C-C chemokine ligand 2 (CCL2) recruits macrophage-membrane-camouflaged hollow bismuth selenide nanoparticles to facilitate photothermal sensitivity and inhibit lung metastasis of breast cancer. ACS Appl. Mater. Interfaces 10(37), 31124–31135 (2018). https://doi.org/10.1021/acsami.8b11645
  133. L. Zhang, Y. Zhang, Y. Xue, Y. Wu, Q. Wang, L. Xue, Z. Su, C. Zhang, Transforming weakness into strength: photothermal-therapy-induced inflammation enhanced cytopharmaceutical chemotherapy as a combination anticancer treatment. Adv. Mater. 31(5), e1805936 (2019). https://doi.org/10.1002/adma.201805936
  134. Q. Zhang, D. Dehaini, Y. Zhang, J. Zhou, X. Chen et al., Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis. Nat. Nanotechnol. 13(12), 1182–1190 (2018). https://doi.org/10.1038/s41565-018-0254-4
  135. J. Xia, Y. Cheng, H. Zhang, R. Li, Y. Hu, B. Liu, The role of adhesions between homologous cancer cells in tumor progression and targeted therapy. Expert Rev. Anticancer Ther. 17(6), 517–526 (2017). https://doi.org/10.1080/14737140.2017.1322511
  136. R.J.C. Bose, R. Paulmurugan, J. Moon, S.-H. Lee, H. Park, Cell membrane-coated nanocarriers: the emerging targeted delivery system for cancer theranostics. Drug Discov. Today 23(4), 891–899 (2018). https://doi.org/10.1016/j.drudis.2018.02.001
  137. J.-Y. Zhu, D.-W. Zheng, M.-K. Zhang, W.-Y. Yu, W.-X. Qiu, J.-J. Hu, J. Feng, X.-Z. Zhang, Preferential cancer cell self-recognition and tumor self-targeting by coating nanoparticles with homotypic cancer cell membranes. Nano Lett. 16(9), 5895–5901 (2016). https://doi.org/10.1021/acs.nanolett.6b02786
  138. N. Kamaly, Z. Xiao, P.M. Valencia, A.F. Radovic-Moreno, O.C. Farokhzad, Targeted polymeric therapeutic nanoparticles: design, development and clinical translation. Chem. Soc. Rev. 41(7), 2971–3010 (2012). https://doi.org/10.1039/c2cs15344k
  139. R.H. Fang, C.-M.J. Hu, B.T. Luk, W. Gao, J.A. Copp, Y. Tai, D.E. O’Connor, L. Zhang, Cancer cell membrane-coated nanoparticles for anticancer vaccination and drug delivery. Nano Lett. 14(4), 2181–2188 (2014). https://doi.org/10.1021/nl500618u
  140. S. Zhao, S. Sun, K. Jiang, Y. Wang, Y. Liu, S. Wu, Z. Li, Q. Shu, H. Lin, In situ synthesis of fluorescent mesoporous silica-carbon dot nanohybrids featuring folate receptor-overexpressing cancer cell targeting and drug delivery. Nano-Micro Lett. 11(1), 32 (2019). https://doi.org/10.1007/s40820-019-0263-3
  141. H. Sun, J. Su, Q. Meng, Q. Yin, L. Chen et al., Cancer-cell-biomimetic nanoparticles for targeted therapy of homotypic tumors. Adv. Mater. 28(43), 9581–9588 (2016). https://doi.org/10.1002/adma.201602173
  142. V. Balasubramanian, A. Correia, H. Zhang, F. Fontana, E. Makila, J. Salonen, J. Hirvonen, H.A. Santos, Biomimetic engineering using cancer cell membranes for designing compartmentalized nanoreactors with organelle-like functions. Adv. Mater. 29(11), 1605375 (2017). https://doi.org/10.1002/adma.201605375
  143. C.M. Liu, G.B. Chen, H.H. Chen, J.B. Zhang, H.Z. Li et al., Cancer cell membrane-cloaked mesoporous silica nanoparticles with a pH-sensitive gatekeeper for cancer treatment. Colloids Surf. B 175, 477–486 (2019). https://doi.org/10.1016/j.colsurfb.2018.12.038
  144. J. Zhu, M. Zhang, D. Zheng, S. Hong, J. Feng, X.-Z. Zhang, A universal approach to render nanomedicine with biological identity derived from cell membranes. Biomacromol 19(6), 2043–2052 (2018). https://doi.org/10.1021/acs.biomac.8b00242
  145. S.Y. Li, H. Cheng, B.R. Xie, W.X. Qiu, J.Y. Zeng et al., Cancer cell membrane camouflaged cascade bioreactor for cancer targeted starvation and photodynamic therapy. ACS Nano 11(7), 7006–7018 (2017). https://doi.org/10.1021/acsnano.7b02533
  146. Z. Yu, P. Zhou, W. Pan, N. Li, B. Tang, A biomimetic nanoreactor for synergistic chemiexcited photodynamic therapy and starvation therapy against tumor metastasis. Nat. Commun. 9(1), 5044 (2018). https://doi.org/10.1038/s41467-018-07197-8
  147. Y.J. Li, C.X. Yang, X.P. Yan, Biomimetic persistent luminescent nanoplatform for autofluorescence-free metastasis tracking and chemophotodynamic therapy. Anal. Chem. 90(6), 4188–4195 (2018). https://doi.org/10.1021/acs.analchem.8b00311
  148. Z. Chen, P. Zhao, Z. Luo, M. Zheng, H. Tian et al., Cancer cell membrane-biomimetic nanoparticles for homologous-targeting dual-modal imaging and photothermal therapy. ACS Nano 10(11), 10049–10057 (2016). https://doi.org/10.1021/acsnano.6b04695
  149. N. Zhang, M. Li, X. Sun, H. Jia, W. Liu, Nir-responsive cancer cytomembrane-cloaked carrier-free nanosystems for highly efficient and self-targeted tumor drug delivery. Biomaterials 159, 25–36 (2018). https://doi.org/10.1016/j.biomaterials.2018.01.007
  150. A.V. Kroll, R.H. Fang, Y. Jiang, J. Zhou, X. Wei et al., Nanoparticulate delivery of cancer cell membrane elicits multiantigenic antitumor immunity. Adv. Mater. 29(47), 1703969 (2017). https://doi.org/10.1002/adma.201703969
  151. N. Yang, Y. Ding, Y. Zhang, B. Wang, X. Zhao et al., Surface functionalization of polymeric nanoparticles with umbilical cord-derived mesenchymal stem cell membrane for tumor-targeted therapy. ACS Appl. Mater. Interfaces 10(27), 22963–22973 (2018). https://doi.org/10.1021/acsami.8b05363
  152. R.J. Bose, B.J. Kim, Y. Arai, I.B. Han, J.J. Moon, R. Paulmurugan, H. Park, S.H. Lee, Bioengineered stem cell membrane functionalized nanocarriers for therapeutic targeting of severe hindlimb ischemia. Biomaterials 185, 360–370 (2018). https://doi.org/10.1016/j.biomaterials.2018.08.018
  153. N. Erez, M. Truitt, P. Olson, D. Hanahan, Cancer-associated fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an nf-kappa b-dependent manner. Cancer Cell 17(2), 135–147 (2010). https://doi.org/10.1016/j.ccr.2009.12.041
  154. J. Li, X. Zhen, Y. Lyu, Y. Jiang, J. Huang, K. Pu, Cell membrane coated semiconducting polymer nanoparticles for enhanced multimodal cancer phototheranostics. ACS Nano 12(8), 8520–8530 (2018). https://doi.org/10.1021/acsnano.8b04066
  155. J. Tan, L. Liu, B. Li, Q. Xie, J. Sun, H. Pu, L. Zhang, Pancreatic stem cells differentiate into insulin-secreting cells on fibroblast-modified PLGA membranes. Mater. Sci. Eng. C Mater. Biol. Appl. 97, 593–601 (2019). https://doi.org/10.1016/j.msec.2018.12.062
  156. C.C. Lin, K.S. Anseth, Cell-cell communication mimicry with poly(ethylene glycol) hydrogels for enhancing beta-cell function. Proc. Natl. Acad. Sci. U.S.A. 108(16), 6380–6385 (2011). https://doi.org/10.1073/pnas.1014026108
  157. W. Gao, R.H. Fang, S. Thamphiwatana, B.T. Luk, J. Li et al., Modulating antibacterial immunity via bacterial membrane-coated nanoparticles. Nano Lett. 15(2), 1403–1409 (2015). https://doi.org/10.1021/nl504798g
  158. A. Poetsch, D. Wolters, Bacterial membrane proteomics. Proteomics 8(19), 4100–4122 (2008). https://doi.org/10.1002/pmic.200800273
  159. A.-N. Zhang, W. Wu, C. Zhang, Q.-Y. Wang, Z.-N. Zhuang, H. Cheng, X.-Z. Zhang, A versatile bacterial membrane-binding chimeric peptide with enhanced photodynamic antimicrobial activity. J. Mater. Chem. B 7(7), 1087–1095 (2019). https://doi.org/10.1039/c8tb03094d
  160. Y. Liu, X. Wang, B. Ouyang, X. Liu, Y. Du et al., Erythrocyte–platelet hybrid membranes coating polypyrrol nanoparticles for enhanced delivery and photothermal therapy. J. Mater. Chem. B 6(43), 7033–7041 (2018). https://doi.org/10.1039/c8tb02143k
  161. D. Wang, H. Dong, M. Li, Y. Cao, F. Yang et al., Erythrocyte-cancer hybrid membrane camouflaged hollow copper sulfide nanoparticles for prolonged circulation life and homotypic-targeting photothermal/chemotherapy of melanoma. ACS Nano 12(6), 5241–5252 (2018). https://doi.org/10.1021/acsnano.7b08355
  162. Q. Jiang, Y. Liu, R. Guo, X. Yao, S. Sung, Z. Pang, W. Yang, Erythrocyte-cancer hybrid membrane-camouflaged melanin nanoparticles for enhancing photothermal therapy efficacy in tumors. Biomaterials 192, 292–308 (2019). https://doi.org/10.1016/j.biomaterials.2018.11.021
  163. H. He, C. Guo, J. Wang, W.J. Korzun, X.Y. Wang, S. Ghosh, H. Yang, Leutusome: a biomimetic nanoplatform integrating plasma membrane components of leukocytes and tumor cells for remarkably enhanced solid tumor homing. Nano Lett. 18(10), 6164–6174 (2018). https://doi.org/10.1021/acs.nanolett.8b01892
  164. L. Rao, Q.-F. Meng, Q. Huang, Z. Wang, G.-T. Yu et al., Platelet-leukocyte hybrid membrane-coated immunomagnetic beads for highly efficient and highly specific isolation of circulating tumor cells. Adv. Funct. Mater. 28(34), 1803531 (2018). https://doi.org/10.1002/adfm.201803531
  165. P. Angsantikul, R.H. Fang, L. Zhang, Toxoid vaccination against bacterial infection using cell membrane-coated nanoparticles. Bioconjug. Chem. 29(3), 604–612 (2018). https://doi.org/10.1021/acs.bioconjchem.7b00692
  166. C.M. Hu, R.H. Fang, J. Copp, B.T. Luk, L. Zhang, A biomimetic nanosponge that absorbs pore-forming toxins. Nat. Nanotechnol. 8(5), 336–340 (2013). https://doi.org/10.1038/nnano.2013.54
  167. Y. Chen, Y. Zhang, M. Chen, J. Zhuang, R.H. Fang, W. Gao, L. Zhang, Biomimetic nanosponges suppress in vivo lethality induced by the whole secreted proteins of pathogenic bacteria. Small 15(6), 1804994 (2019). https://doi.org/10.1002/smll.201804994
  168. M.S. Chen, Y. Zhang, L. Zhang, Fabrication and characterization of a 3D bioprinted nanoparticle-hydrogel hybrid device for biomimetic detoxification. Nanoscale 9(38), 14506–14511 (2017). https://doi.org/10.1039/c7nr05322c
  169. J. Li, P. Angsantikul, W. Liu, B.E.-F. de Avila, X. Chang et al., Biomimetic platelet-camouflaged nanorobots for binding and isolation of biological threats. Adv. Mater. 30(2), 1704800 (2018). https://doi.org/10.1002/adma.201704800
  170. B.E.-F.D. d Ávila, P. Angsantikul, D.E. Ramírez-Herrera, F. Soto, H. Teymourian, D. Dehaini, Y. Chen, L. Zhang, J. Wang, Hybrid biomembrane-functionalized nanorobots for concurrent removal of pathogenic bacteria and toxins. Sci. Robot. 3(18), aat0485 (2018). https://doi.org/10.1126/scirobotics.aat0485
  171. H. Ye, K. Wang, M. Wang, R. Liu, H. Song et al., Bioinspired nanoplatelets for chemo-photothermal therapy of breast cancer metastasis inhibition. Biomaterials 206, 1–12 (2019). https://doi.org/10.1016/j.biomaterials.2019.03.024
  172. S. Krishnamurthy, M.K. Gnanasammandhan, C. Xie, K. Huang, M.Y. Cui, J.M. Chan, Monocyte cell membrane-derived nanoghosts for targeted cancer therapy. Nanoscale 8(13), 6981–6985 (2016). https://doi.org/10.1039/c5nr07588b
  173. Y. Huang, C. Mei, Y. Tian, T. Nie, Z. Liu, T. Chen, Bioinspired tumor-homing nanosystem for precise cancer therapy via reprogramming of tumor-associated macrophages. NPG Asia Mater. 10(10), 1002–1015 (2018). https://doi.org/10.1038/s41427-018-0091-9
  174. J. Su, H. Sun, Q. Meng, Q. Yin, P. Zhang, Z. Zhang, H. Yu, Y. Li, Bioinspired nanoparticles with NIR-controlled drug release for synergetic chemophotothermal therapy of metastatic breast cancer. Adv. Funct. Mater. 26(41), 7495–7506 (2016). https://doi.org/10.1002/adfm.201603381
  175. J.N. Ma, S.Q. Zhang, J. Liu, F.Y. Liu, F. Du et al., Targeted drug delivery to stroke via chemotactic recruitment of nanoparticles coated with membrane of engineered neural stem cells. Small 15(35), 1902011 (2019). https://doi.org/10.1002/smll.201902011
  176. C. Tapeinos, F. Tomatis, M. Battaglini, A. Larranaga, A. Marino et al., Cell membrane-coated magnetic nanocubes with a homotypic targeting ability increase intracellular temperature due to ROS scavenging and act as a versatile theranostic system for glioblastoma multiforme. Adv. Healthc. Mater. 8(18), 1900612 (2019). https://doi.org/10.1002/adhm.201900612
Read More
Author biographies are not available.
Download this PDF file
PDF
Statistic
Read Counter : 8745 Download : 6635

Most read articles by the same author(s)

1 2 > >>