Real Nano “Light Vaccine” Will Benefit to COVID-19 Pandemic Control
Corresponding Author: Jianshe Yang
Nano-Micro Letters,
Vol. 13 (2021), Article Number: 185
Abstract
This highlight presents a recent technique of “Light Vaccine” for COVID-19 pandemic control. Though this technique has the germicidal advantage to SARS-CoV-2, its shortcomings will limit the wide and in-depth application. We make a perspective of real nano light vaccine, which will play an important role in the prevention and control of COVID-19. Briefly, This flow chart described the MWCNT was fabricated with strong acid and base conditional mixture in order to achieve the p-WCNT (chemical process); then modified with RNA layse and receptor binding domain (RBD) by covalent conjugation and physical absorption to get f-WCNT (functionalization); thereafter, f-WCNT was used in the multi-cell culture system interacting with SARS-CoV-2 to identify the special affinity of f-WCNT to ACE2 labeled alveolar type II cells and the inhibition capacity to SARS-CoV-2. This design, is different from the so called “light vaccine”, has the real function to against SARS-CoV-2 by local cellular temperature-rising through photothermal conversion under the near infrared (NIR) light irradiation, according to the physical and chemical nature of carbon nanotubes, and initiates the immune response consequently.
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- https://news.fudan.edu.cn/2021/0813/c5a109838/page.htm
- M. Buonanno, B. Ponnaiya, D. Welch, M. Stanislauskas, G. Randers-Pehrson et al., Germicidal efficacy and mammalian skin safety of 222-nm UV light. Radiat. Res. 187, 483–491 (2017). https://doi.org/10.1667/RR0010CC.1
- D. Welch, M. Buonanno, V. Grilj, I. Shuryak, C. Crickmore et al., Far-UVC light: A new tool to control the spread of airborne-mediated microbial diseases. Sci. Rep. 8, 2752 (2018). https://doi.org/10.1038/s41598-018-21058-w
- B. Ponnaiya, M. Buonanno, D. Welch, I. Shuryak, G. Randers-Pehrson et al., Far-UVC light prevents MRSA infection of superficial wounds in vivo. PLoS ONE 13, e0192053 (2018). https://doi.org/10.1371/journal.pone.0192053
- M. Buonanno, D. Welch, I. Shuryak, D.J. Brenner, Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses. Sci. Rep. 10, 10285 (2020). https://doi.org/10.1038/s41598-020-67211-2
- J.S. Yang, Inhibition of SARS-CoV-2 replication by acidizing and RNA lyase-modified carbon nanotubes combined with photodynamic thermal effect. J. Explor. Res. Pharmacol. 5, 18–23 (2020). https://doi.org/10.14218/JERP.2020.00005
References
https://news.fudan.edu.cn/2021/0813/c5a109838/page.htm
M. Buonanno, B. Ponnaiya, D. Welch, M. Stanislauskas, G. Randers-Pehrson et al., Germicidal efficacy and mammalian skin safety of 222-nm UV light. Radiat. Res. 187, 483–491 (2017). https://doi.org/10.1667/RR0010CC.1
D. Welch, M. Buonanno, V. Grilj, I. Shuryak, C. Crickmore et al., Far-UVC light: A new tool to control the spread of airborne-mediated microbial diseases. Sci. Rep. 8, 2752 (2018). https://doi.org/10.1038/s41598-018-21058-w
B. Ponnaiya, M. Buonanno, D. Welch, I. Shuryak, G. Randers-Pehrson et al., Far-UVC light prevents MRSA infection of superficial wounds in vivo. PLoS ONE 13, e0192053 (2018). https://doi.org/10.1371/journal.pone.0192053
M. Buonanno, D. Welch, I. Shuryak, D.J. Brenner, Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses. Sci. Rep. 10, 10285 (2020). https://doi.org/10.1038/s41598-020-67211-2
J.S. Yang, Inhibition of SARS-CoV-2 replication by acidizing and RNA lyase-modified carbon nanotubes combined with photodynamic thermal effect. J. Explor. Res. Pharmacol. 5, 18–23 (2020). https://doi.org/10.14218/JERP.2020.00005