Issue

Vol. 13 (2021)

Targeted Sub-Attomole Cancer Biomarker Detection Based on Phase Singularity 2D Nanomaterial-Enhanced Plasmonic Biosensor

https://doi.org/10.1007/s40820-021-00613-7
Yuye Wang
Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People’s Republic of China
Shuwen Zeng
CNRS, XLIM Research Institute, UMR 7252, University of Limoges, 123, Avenue Albert Thomas, Limoges, France
Aurelian Crunteanu
CNRS, XLIM Research Institute, UMR 7252, University of Limoges, 123, Avenue Albert Thomas, Limoges, France
Zhenming Xie
Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People’s Republic of China
Georges Humbert
CNRS, XLIM Research Institute, UMR 7252, University of Limoges, 123, Avenue Albert Thomas, Limoges, France
Libo Ma
Institute for Integrative Nanosciences, IFW Dresden, Helmholtzstr. 20, Dresden, Germany
Yuanyuan Wei
Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People’s Republic of China
Aude Brunel
Faculty of Medicine, University of Limoges, EA3842‑CAPTuR, GEIST, 2 rue du Dr Marcland, Limoges, France
Barbara Bessette
Faculty of Medicine, University of Limoges, EA3842‑CAPTuR, GEIST, 2 rue du Dr Marcland, Limoges, France
Jean‑Christophe Orlianges
CNRS, XLIM Research Institute, UMR 7252, University of Limoges, 123, Avenue Albert Thomas, Limoges, France
Fabrice Lalloué
Faculty of Medicine, University of Limoges, EA3842‑CAPTuR, GEIST, 2 rue du Dr Marcland, Limoges, France
Oliver G. Schmidt
Institute for Integrative Nanosciences, IFW Dresden, Helmholtzstr. 20, Dresden, Germany
Nanfang Yu
Department of Applied Physics and Applied Mathematics, Columbia University, New York City, NY, USA
Ho‑Pui Ho
Department of Biomedical Engineering, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People’s Republic of China

Corresponding Author: Ho‑Pui Ho

aaron.ho@cuhk.edu.hk

Nano-Micro Letters, Vol. 13 (2021), Article Number: 96

Abstract

Detection of small cancer biomarkers with low molecular weight and a low concentration range has always been challenging yet urgent in many clinical applications such as diagnosing early-stage cancer, monitoring treatment and detecting relapse. Here, a highly enhanced plasmonic biosensor that can overcome this challenge is developed using atomically thin two-dimensional phase change nanomaterial. By precisely engineering the configuration with atomically thin materials, the phase singularity has been successfully achieved with a significantly enhanced lateral position shift effect. Based on our knowledge, it is the first experimental demonstration of a lateral position signal change > 340 μm at a sensing interface from all optical techniques. With this enhanced plasmonic effect, the detection limit has been experimentally demonstrated to be 10–15 mol L−1 for TNF-α cancer marker, which has been found in various human diseases including inflammatory diseases and different kinds of cancer. The as-reported novel integration of atomically thin Ge2Sb2Te5 with plasmonic substrate, which results in a phase singularity and thus a giant lateral position shift, enables the detection of cancer markers with low molecular weight at femtomolar level. These results will definitely hold promising potential in biomedical application and clinical diagnostics.


Highlights:


1 A zero-reflection-induced phase singularity is achieved through precisely controlling the resonance characteristics using two-dimensional nanomaterials.
2 An atomically thin nano-layer having a high absorption coefficient is exploited to enhance the zero-reflection dip, which has led to the subsequent phase singularity and thus a giant lateral position shift.
3 We have improved the detection limit of low molecular weight molecules by more than three orders of magnitude compared to current state-of-art nanomaterial-enhanced plasmonic sensors.

Keywords

2D nanomaterials Cancer marker detection Phase singularity Surface plasmon
Wang, Yuye, Shuwen Zeng, Aurelian Crunteanu, Zhenming Xie, Georges Humbert, Libo Ma, Yuanyuan Wei, Aude Brunel, Barbara Bessette, Jean‑Christophe Orlianges, Fabrice Lalloué, Oliver G. Schmidt, Nanfang Yu, and Ho‑Pui Ho. 2021. “Targeted Sub-Attomole Cancer Biomarker Detection Based on Phase Singularity 2D Nanomaterial-Enhanced Plasmonic Biosensor”. Nano-Micro Letters 13 (March):96. https://doi.org/10.1007/s40820-021-00613-7.
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