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Vol. 4 No. 2 (2012)

Cavity Control of Prefoldin Nano Actuator (PNA) by Temperature and pH

https://doi.org/10.1007/BF03353701
Ali Shokuhfar
Department of Mechanical Engineering, K.N. Toosi University of Technology, #19 Pardiss Alley, Sadra Street, Vanak Square, Tehran, Iran
Ali Ghaffari
Department of Mechanical Engineering, K.N. Toosi University of Technology, #19 Pardiss Alley, Sadra Street, Vanak Square, Tehran, Iran
Reza Hasanzadeh Ghasemi
Department of Mechanical Engineering, K.N. Toosi University of Technology, #19 Pardiss Alley, Sadra Street, Vanak Square, Tehran, Iran

Corresponding Author: Reza Hasanzadeh Ghasemi

r_hasanzadeh@dena.kntu.ac.ir

Nano-Micro Letters, Vol. 4 No. 2 (2012), Article Number: 110-117

Abstract

A molecular dynamics study to investigate the cavity control of Prefoldin based bio nano actuator is presented in this paper. Prefoldin is a molecular chaperone with a jellyfish-like structure containing six long coiled-coil tentacles and a large central cavity. We took the temperature and pH of the medium into account, and analyzed the conformational flexibility of the Prefoldin nano actuator in details. Results show that the prefoldin is a very flexible protein, the conformational state of which appears to depend on the temperature and pH values of the medium. In fact, combining these two control parameters, a suitable environment is provided to capture nano cargoes with specific dimensions. These properties of Prefoldin actuator can be used for drug delivery in the body.

Keywords

Prefoldin Nano Actuator (PNA) Cavity control Molecular Dynamics GROMACS
Shokuhfar, Ali, Ali Ghaffari, and Reza Hasanzadeh Ghasemi. 2012. “Cavity Control of Prefoldin Nano Actuator (PNA) by Temperature and PH”. Nano-Micro Letters 4 (2):110-17. https://doi.org/10.1007/BF03353701.
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