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Vol. 12 (2020)

RBC Membrane Camouflaged Semiconducting Polymer Nanoparticles for Near-Infrared Photoacoustic Imaging and Photothermal Therapy

https://doi.org/10.1007/s40820-020-00429-x
Dongye Zheng
School of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, People’s Republic of China
Peiwen Yu
The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, People’s Republic of China
Zuwu Wei
The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, People’s Republic of China
Cheng Zhong
Department of Chemistry, Hubei Key Lab on Organic and Polymeric Optoelectronic Materials, Wuhan University, Wuhan 430072, People’s Republic of China
Ming Wu
The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, People’s Republic of China
Xiaolong Liu
School of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, People’s Republic of China

Corresponding Author: Xiaolong Liu

xiaoloong.liu@gmail.com

Nano-Micro Letters, Vol. 12 (2020), Article Number: 94

Abstract

Semiconducting conjugated polymer nanoparticles (SPNs) represent an emerging class of phototheranostic materials with great promise for cancer treatment. In this report, low-bandgap electron donor–acceptor (D–A)-conjugated SPNs with surface cloaked by red blood cell membrane (RBCM) are developed for highly effective photoacoustic imaging and photothermal therapy. The resulting RBCM-coated SPN (SPN@RBCM) displays remarkable near-infrared light absorption and good photostability, as well as high photothermal conversion efficiency for photoacoustic imaging and photothermal therapy. Particularly, due to the small size (< 5 nm), SPN@RBCM has the advantages of deep tumor penetration and rapid clearance from the body with no appreciable toxicity. The RBCM endows the SPNs with prolonged systematic circulation time, less reticuloendothelial system uptake and reduced immune-recognition, hence improving tumor accumulation after intravenous injection, which provides strong photoacoustic signals and exerts excellent photothermal therapeutic effects. Thus, this work provides a valuable paradigm for safe and highly efficient tumor photoacoustic imaging and photothermal therapy for further clinical translation.


Highlights:


1 A narrow bandgap electron donor–acceptor (D–A) semiconducting polymer nanoparticle (SPN) coated with red blood cell membrane (RBCM) for photoacoustic imaging and photothermal therapy.
2 The D–A structure endows SPN with excellent near-infrared absorbance, high photothermal conversion ability, and good photothermal stability.
3 The RBCM endows SPN with good biocompatibility, prolonged blood circulation, and improved tumor accumulation, while the small size structure endows SPN with deep tumor penetration and rapid clearance from body.

Keywords

Semiconducting conjugated polymer nanoparticles Red blood cell membrane camouflage Deep tumor penetration Photoacoustic imaging Photothermal therapy
Zheng, Dongye, Peiwen Yu, Zuwu Wei, Cheng Zhong, Ming Wu, and Xiaolong Liu. 2020. “RBC Membrane Camouflaged Semiconducting Polymer Nanoparticles for Near-Infrared Photoacoustic Imaging and Photothermal Therapy”. Nano-Micro Letters 12 (April):94. https://doi.org/10.1007/s40820-020-00429-x.
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