Issue

Vol. 11 (2019)

Crushed Gold Shell Nanoparticles Labeled with Radioactive Iodine as a Theranostic Nanoplatform for Macrophage-Mediated Photothermal Therapy

https://doi.org/10.1007/s40820-019-0266-0
Sang Bong Lee
New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea
Jae‑Eon Lee
Department of Biomaterials Science, College of Natural Resources and Life Science/Life and Industry Convergence Research Institute, Pusan National University, Pusan, South Korea
Sung Jin Cho
New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea
Jungwook Chin
New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, South Korea
Sang Kyoon Kim
Laboratory Animal Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 360‑4, South Korea
In‑Kyu Lee
Leading‑Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu 702‑210, South Korea
Sang‑Woo Lee
Leading‑Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu 702‑210, South Korea
Jaetae Lee
Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu 702‑210, South Korea
Yong Hyun Jeon
Leading‑Edge Research Center for Drug Discovery and Development for Diabetes and Metabolic Disease, Kyungpook National University Hospital, Daegu 702‑210, South Korea

Corresponding Author: Yong Hyun Jeon

jeon9014@gmail.com

Nano-Micro Letters, Vol. 11 (2019), Article Number: 36

Abstract

Plasmonic nanostructure-mediated photothermal therapy (PTT) has proven to be a promising approach for cancer treatment, and new approaches for its effective delivery to tumor lesions are currently being developed. This study aimed to assess macrophage-mediated delivery of PTT using radioiodine-124-labeled gold nanoparticles with crushed gold shells (124I-Au@AuCBs) as a theranostic nanoplatform. 124I-Au@AuCBs exhibited effective photothermal conversion effects both in vitro and in vivo and were efficiently taken up by macrophages without cytotoxicity. After the administration of 124I-Au@AuCB-labeled macrophages to colon tumors, intensive signals were observed at tumor lesions, and subsequent in vivo PTT with laser irradiation yielded potent antitumor effects. The results indicate the considerable potential of 124I-Au@AuCBs as novel theranostic nanomaterials and the prominent advantages of macrophage-mediated cellular therapies in treating cancer and other diseases.


Highlights:


1 Crushed gold shell radionuclide nanoballs (124I-Au@AuCBs) were fabricated as unique photothermal therapeutics and nuclear medicine imaging nanoplatforms.
2 Macrophage-mediated delivery of 124I-Au@AuCBs and their potential photothermal therapy applications were demonstrated in mice with colon cancer.

Keywords

Photothermal therapy Radionuclide crushed gold shell nanoballs Macrophage-mediated delivery
Lee, Sang Bong, Jae‑Eon Lee, Sung Jin Cho, Jungwook Chin, Sang Kyoon Kim, In‑Kyu Lee, Sang‑Woo Lee, Jaetae Lee, and Yong Hyun Jeon. 2019. “Crushed Gold Shell Nanoparticles Labeled With Radioactive Iodine As a Theranostic Nanoplatform for Macrophage-Mediated Photothermal Therapy”. Nano-Micro Letters 11 (May):36. https://doi.org/10.1007/s40820-019-0266-0.
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. E. Boisselier, D. Astruc, Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity. Chem. Soc. Rev. 38(6), 1759–1782 (2009). https://doi.org/10.1039/b806051g
  2. M. Hu, J. Chen, Z.Y. Li, L. Au, G.V. Hartland, X. Li, M. Marquez, Y. Xia, Gold nanostructures: engineering their plasmonic properties for biomedical applications. Chem. Soc. Rev. 35(11), 1084–1094 (2006). https://doi.org/10.1039/b517615h
  3. M.P. Melancon, W. Lu, Z. Yang, R. Zhang, Z. Cheng et al., In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy. Mol. Cancer Ther. 7(6), 1730–1739 (2008). https://doi.org/10.1158/1535-7163.MCT-08-0016
  4. X. Ji, R. Shao, A.M. Elliott, R.J. Stafford, E. Esparza-Coss et al., Bifunctional gold nanoshells with a superparamagnetic iron oxide–silica core suitable for both MR imaging and photothermal therapy. J. Phys. Chem. C 111(17), 6245–6251 (2007). https://doi.org/10.1021/jp0702245
  5. H. Liu, D. Chen, L. Li, T. Liu, L. Tan, X. Wu, F. Tang, Multifunctional gold nanoshells on silica nanorattles: a platform for the combination of photothermal therapy and chemotherapy with low systemic toxicity. Angew. Chem. Int. Ed. 50(4), 891–895 (2011). https://doi.org/10.1002/anie.201002820
  6. Z. Li, P. Huang, X. Zhang, J. Lin, S. Yang, RGD-conjugated dendrimer-modified gold nanorods for in vivo tumor targeting and photothermal therapy. Mol. Pharm. 7(1), 94–104 (2009). https://doi.org/10.1021/mp9001415
  7. J. Chen, D. Wang, J. Xi, L. Au, A. Siekkinen et al., Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells. Nano Lett. 7(5), 1318–1322 (2007). https://doi.org/10.1021/nl070345g
  8. J. Chen, C. Glaus, R. Laforest, Q. Zhang, M. Yang, M. Gidding, M.J. Welch, Y. Xia, Gold nanocages as photothermal transducers for cancer treatment. Small 6(7), 811–817 (2010). https://doi.org/10.1002/smll.200902216
  9. L. Au, D. Zheng, F. Zhou, Z.-Y. Li, X. Li, Y. Xia, A quantitative study on the photothermal effect of immuno gold nanocages targeted to breast cancer cells. ACS Nano 2(8), 1645–1652 (2008). https://doi.org/10.1021/nn800370j
  10. J. Yang, D. Shen, L. Zhou, W. Li, X. Li et al., Spatially confined fabrication of core–shell gold nanocages@mesoporous silica for near-infrared controlled photothermal drug release. Chem. Mater. 25(15), 3030–3037 (2013). https://doi.org/10.1021/cm401115b
  11. L. Tong, Q. Wei, A. Wei, J.X. Cheng, Gold nanorods as contrast agents for biological imaging: optical properties, surface conjugation and photothermal effects. Photochem. Photobiol. 85(1), 21–32 (2009). https://doi.org/10.1111/j.1751-1097.2008.00507.x
  12. E.B. Dickerson, E.C. Dreaden, X. Huang, I.H. El-Sayed, H. Chu, S. Pushpanketh, J.F. McDonald, M.A. El-Sayed, Gold nanorod assisted near-infrared plasmonic photothermal therapy (pptt) of squamous cell carcinoma in mice. Cancer Lett. 269(1), 57–66 (2008). https://doi.org/10.1016/j.canlet.2008.04.026
  13. A.M. Alkilany, L.B. Thompson, S.P. Boulos, P.N. Sisco, C.J. Murphy, Gold nanorods: their potential for photothermal therapeutics and drug delivery, tempered by the complexity of their biological interactions. Adv. Drug Deliv. Rev. 64(2), 190–199 (2012). https://doi.org/10.1016/j.addr.2011.03.005
  14. L. Tong, Y. Zhao, T.B. Huff, M.N. Hansen, A. Wei, J.X. Cheng, Gold nanorods mediate tumor cell death by compromising membrane integrity. Adv. Mater. 19(20), 3136–3141 (2007). https://doi.org/10.1002/adma.200701974
  15. G. von Maltzahn, J.-H. Park, A. Agrawal, N.K. Bandaru, S.K. Das, M.J. Sailor, S.N. Bhatia, Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas. Cancer Res. 69(9), 3892–3900 (2009). https://doi.org/10.1158/0008-5472.CAN-08-4242
  16. J. Lin, S. Wang, P. Huang, Z. Wang, S. Chen et al., Photosensitizer-loaded gold vesicles with strong plasmonic coupling effect for imaging-guided photothermal/photodynamic therapy. ACS Nano 7(6), 5320–5329 (2013). https://doi.org/10.1021/nn4011686
  17. H. Yuan, C.G. Khoury, C.M. Wilson, G.A. Grant, A.J. Bennett, T. Vo-Dinh, In vivo particle tracking and photothermal ablation using plasmon-resonant gold nanostars. Nanomed. Nanotechnol. 8(8), 1355–1363 (2012). https://doi.org/10.1016/j.nano.2012.02.005
  18. Y. Wang, K.C. Black, H. Luehmann, W. Li, Y. Zhang et al., Comparison study of gold nanohexapods, nanorods, and nanocages for photothermal cancer treatment. ACS Nano 7(3), 2068–2077 (2013). https://doi.org/10.1021/nn304332s
  19. L. Cheng, C. Wang, L. Feng, K. Yang, Z. Liu, Functional nanomaterials for phototherapies of cancer. Chem. Rev. 114(21), 10869–10939 (2014). https://doi.org/10.1021/cr400532z
  20. A.Z. Wang, R. Langer, O.C. Farokhzad, Nanoparticle delivery of cancer drugs. Annu. Rev. Med. 63, 185–198 (2012). https://doi.org/10.1146/annurev-med-040210-162544
  21. X. Yi, K. Yang, C. Liang, X. Zhong, P. Ning et al., Imaging-guided combined photothermal and radiotherapy to treat subcutaneous and metastatic tumors using iodine-131-doped copper sulfide nanoparticles. Adv. Funct. Mater. 25(29), 4689–4699 (2015). https://doi.org/10.1002/adfm.201502003
  22. T.D. Yang, W. Choi, T.H. Yoon, K.J. Lee, J.-S. Lee et al., In vivo photothermal treatment by the peritumoral injection of macrophages loaded with gold nanoshells. Biomed. Opt. Express 7(1), 185–193 (2016). https://doi.org/10.1364/BOE.7.000185
  23. B.-K. Wang, X.-F. Yu, J.-H. Wang, Z.-B. Li, P.-H. Li, H. Wang, L. Song, P.K. Chu, C. Li, Gold-nanorods-siRNA nanoplex for improved photothermal therapy by gene silencing. Biomaterials 78, 27–39 (2016). https://doi.org/10.1016/j.biomaterials.2015.11.025
  24. Y. Liu, M. Yang, J. Zhang, X. Zhi, C. Li, C. Zhang, F. Pan, K. Wang, Y. Yang, J. Martinez de la Fuentea, Human induced pluripotent stem cells for tumor targeted delivery of gold nanorods and enhanced photothermal therapy. ACS Nano 10(2), 2375–2385 (2016). https://doi.org/10.1021/acsnano.5b07172
  25. S. Tang, M. Chen, N. Zheng, Sub-10-nm Pd nanosheets with renal clearance for efficient near-infrared photothermal cancer therapy. Small 10(15), 3139–3144 (2014). https://doi.org/10.1002/smll.201303631
  26. S. Kang, S.H. Bhang, S. Hwang, J.K. Yoon, J. Song, H.K. Jang, S. Kim, B.S. Kim, Mesenchymal stem cells aggregate and deliver gold nanoparticles to tumors for photothermal therapy. ACS Nano 9(10), 9678–9690 (2015). https://doi.org/10.1021/acsnano.5b02207
  27. M.-R. Choi, K.J. Stanton-Maxey, J.K. Stanley, C.S. Levin et al., A cellular trojan horse for delivery of therapeutic nanoparticles into tumors. Nano Lett. 7(12), 3759–3765 (2007). https://doi.org/10.1021/nl072209h
  28. S.J. Madsen, S.-K. Baek, A.R. Makkouk, T. Krasieva, H. Hirschberg, Macrophages as cell-based delivery systems for nanoshells in photothermal therapy. Annu. Biomed. Eng. 40(2), 507–515 (2012). https://doi.org/10.1007/s10439-011-0415-1
  29. J. Choi, H.-Y. Kim, E.J. Ju, J. Jung, J. Park et al., Use of macrophages to deliver therapeutic and imaging contrast agents to tumors. Biomaterials 33(16), 4195–4203 (2012). https://doi.org/10.1016/j.biomaterials.2012.02.022
  30. M.T. Stephan, S.B. Stephan, P. Bak, J. Chen, D.J. Irvine, Synapse-directed delivery of immunomodulators using t-cell-conjugated nanoparticles. Biomaterials 33(23), 5776–5787 (2012). https://doi.org/10.1016/j.biomaterials.2012.04.029
  31. Z. Li, H. Huang, S. Tang, Y. Li, X.-F. Yu et al., Small gold nanorods laden macrophages for enhanced tumor coverage in photothermal therapy. Biomaterials 74, 144–154 (2016). https://doi.org/10.1016/j.biomaterials.2015.09.038
  32. S.B. Lee, D. Kumar, Y. Li, I.-K. Lee, S.J. Cho et al., Pegylated crushed gold shell-radiolabeled core nanoballs for in vivo tumor imaging with dual positron emission tomography and cerenkov luminescent imaging. J. Nanobiotechnol. 16(1), 41 (2018). https://doi.org/10.1186/s12951-018-0366-x
  33. S.B. Lee, S.-W. Lee, S.Y. Jeong, G. Yoon, S.J. Cho et al., Engineering of radioiodine-labeled gold core–shell nanoparticles as efficient nuclear medicine imaging agents for trafficking of dendritic cells. ACS Appl. Mater. Interfaces 9(10), 8480–8489 (2017). https://doi.org/10.1021/acsami.6b14800
  34. X. Cheng, X. Tian, A. Wu, J. Li, J. Tian et al., Protein corona influences cellular uptake of gold nanoparticles by phagocytic and nonphagocytic cells in a size-dependent manner. ACS Appl. Mater. Interfaces 7(37), 20568–20575 (2015). https://doi.org/10.1021/acsami.5b04290
  35. A. Aderem, D.M. Underhill, Mechanisms of phagocytosis in macrophages. Annu. Rev. Immunol. 17(1), 593–623 (1999). https://doi.org/10.1146/annurev.immunol.17.1.593
  36. D.J. Irvine, M.C. Hanson, K. Rakhra, T. Tokatlian, Synthetic nanoparticles for vaccines and immunotherapy. Chem. Rev. 115(19), 11109–11146 (2015). https://doi.org/10.1021/acs.chemrev.5b00109
  37. A.C. Anselmo, S. Mitragotri, Cell-mediated delivery of nanoparticles: taking advantage of circulatory cells to target nanoparticles. J. Control Release 190, 531–541 (2014). https://doi.org/10.1016/j.jconrel.2014.03.050
Read More
Author biographies are not available.
Download this PDF file
PDF SUPPLEMENTARY MATERIAL
Statistic
Read Counter : 4616 Download : 3479