Issue

Vol. 16 (2024)

Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

https://doi.org/10.1007/s40820-024-01323-6
Amal George Kurian
Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea
Rajendra K. Singh
Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea
Varsha Sagar
Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea
Jung‑Hwan Lee
Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea
Hae‑Won Kim
Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea

Corresponding Author: Hae‑Won Kim

kimhw@dku.edu

Nano-Micro Letters, Vol. 16 (2024), Article Number: 110

Abstract

Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients and the healthcare system. Conventional therapies, such as corticosteroids and nonsteroidal anti-inflammatory drugs, are limited in efficacy and associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise in addressing these challenges. NZ-based hydrogels possess unique therapeutic abilities by combining the therapeutic benefits of redox nanomaterials with enzymatic activity and the water-retaining capacity of hydrogels. The multifaceted therapeutic effects of these hydrogels include scavenging reactive oxygen species and other inflammatory mediators modulating immune responses toward a pro-regenerative environment and enhancing regenerative potential by triggering cell migration and differentiation. This review highlights the current state of the art in NZ-engineered hydrogels (NZ@hydrogels) for anti-inflammatory and skin regeneration applications. It also discusses the underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, the challenges and future directions in this ground, particularly their clinical translation, are addressed. The insights provided in this review can aid in the design and engineering of novel NZ-based hydrogels, offering new possibilities for targeted and personalized skin-care therapies.


Highlights:
1 Nanozyme-based approaches to produce therapeutic hydrogels.
2 Enzymatic mechanisms and multifunctional roles of nanozyme-engineered hydrogels for skin therapy.
3 Therapeutic actions of nanozyme-engineered hydrogels in inflamed skin tissues.
4 Mechanical and immunological aspects of skin therapy guided by nanozyme-engineered hydrogels.
5 Promising directions and challenges of nanozyme-inspired hydrogel platforms.

Keywords

Nanozymes Hydrogels ROS scavenging Anti-inflammation Skin regeneration
Kurian, Amal George, Rajendra K. Singh, Varsha Sagar, Jung‑Hwan Lee, and Hae‑Won Kim. 2024. “Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration”. Nano-Micro Letters 16 (February):110. https://doi.org/10.1007/s40820-024-01323-6.
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