Issue

Vol. 14 (2022)

Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy

https://doi.org/10.1007/s40820-022-00828-2
Xiaodong Zhang
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore
Xiaokai Chen
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore
Yanli Zhao
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore

Corresponding Author: Yanli Zhao

zhaoyanli@ntu.edu.sg

Nano-Micro Letters, Vol. 14 (2022), Article Number: 95

Abstract

Natural enzymes usually suffer from high production cost, ease of denaturation and inactivation, and low yield, making them difficult to be broadly applicable. As an emerging type of artificial enzyme, nanozymes that combine the characteristics of nanomaterials and enzymes are promising alternatives. On the one hand, nanozymes have high enzyme-like catalytic activities to regulate biochemical reactions. On the other hand, nanozymes also inherit the properties of nanomaterials, which can ameliorate the shortcomings of natural enzymes and serve as versatile platforms for diverse applications. In this review, various nanozymes that mimic the catalytic activity of different enzymes are introduced. The achievements of nanozymes in different cancer diagnosis and treatment technologies are summarized by highlighting the advantages of nanozymes in these applications. Finally, future research directions in this rapidly developing field are outlooked.


Highlights:


1 This review introduces nanozymes that exhibit different enzymatic activities and emphasizes the advantages of nanozymes over natural enzymes.
2 The roles of nanozymes in different cancer diagnostic and therapeutic technologies are summarized, explained by representative examples.
3 The potential challenges of nanozyme-based cancer theranostics are outlined, and future research directions are outlooked.

Keywords

Cancer theranostics Catalytic therapy Enzyme mimics Nanozymes Smart nanomedicine
Zhang, Xiaodong, Xiaokai Chen, and Yanli Zhao. 2022. “Nanozymes: Versatile Platforms for Cancer Diagnosis and Therapy”. Nano-Micro Letters 14 (April):95. https://doi.org/10.1007/s40820-022-00828-2.
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